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J-GLOBAL ID：202101006832980457   Update date: Feb. 10, 2025

Hashimoto Takuya

Hashimoto Takuya
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Research theme for competitive and other funds  (3)：
  • 2023 - 2026 腸内細菌のエネルギー獲得経路に起因する心疾患リスク因子産生機構の分子基盤解明
  • 2020 - 2022 Synthesis of desined biosynthetic gene cluster for specialized metabolite to express in different genus host
  • 2018 - 2020 Development of a heterologous expression method for exploitation of large biosynthetic gene clusters over 200 kb.
Papers (15)：
  • Takuya Hashimoto, Hikaru Suenaga, Kazuo Shin-ya. Application of Cas9-Based Gene Editing to Engineering of Nonribosomal Peptide Synthetases. ChemBioChem. 2025
  • Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq-Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie. 2024. 136. 10
  • Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-Ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie (International ed. in English). 2024. e202317805
  • Takuya Hashimoto, Junko Hashimoto, Noritaka Kagaya, Takehiro Nishimura, Hikaru Suenaga, Makoto Nishiyama, Tomohisa Kuzuyama, Kazuo Shin-ya. A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster. The Journal of Antibiotics. 2021. 74. 5. 354-358
  • Reiko Ueoka, Junko Hashimoto, Ikuko Kozone, Takuya Hashimoto, Kei Kudo, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-Ya. A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900. Bioscience, biotechnology, and biochemistry. 2021. 85. 4. 890-894
ｍore...
Committee career (1)：
  • 2017 - 2022 天然物化学談話会 世話人
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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