Hashimoto Takuya

Research theme for competitive and other funds (3)：

2023 - 2026 腸内細菌のエネルギー獲得経路に起因する心疾患リスク因子産生機構の分子基盤解明
2020 - 2022 Synthesis of desined biosynthetic gene cluster for specialized metabolite to express in different genus host
2018 - 2020 Development of a heterologous expression method for exploitation of large biosynthetic gene clusters over 200 kb.

Papers (12)：

Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-Ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie (International ed. in English). 2024. e202317805
Takuya Hashimoto, Junko Hashimoto, Noritaka Kagaya, Takehiro Nishimura, Hikaru Suenaga, Makoto Nishiyama, Tomohisa Kuzuyama, Kazuo Shin-ya. A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster. The Journal of Antibiotics. 2021. 74. 5. 354-358
Reiko Ueoka, Junko Hashimoto, Ikuko Kozone, Takuya Hashimoto, Kei Kudo, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-Ya. A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900. Bioscience, biotechnology, and biochemistry. 2021. 85. 4. 890-894
Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, et al. In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives. Nature Communications. 2020. 11. 1. 4022-4022
Takuya Hashimoto, Ikuko Kozone, Junko Hashimoto, Hikaru Suenaga, Manabu Fujie, Noriyuki Satoh, Haruo Ikeda, Kazuo Shin-ya. Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin. The Journal of Antibiotics. 2020. 73. 9. 650-654

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Committee career (1)：

2017 - 2022 天然物化学談話会世話人

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