Toyota Hiroko

トヨタヒロコ | Toyota Hiroko

Affiliation and department：
Job title： Research Associate
Research theme for competitive and other funds (6)：

2017 - 2021 Study of nano particle cancer vaccines targeting for Dendritic cells.
2016 - 2020 Mechanism of allergic inflammation induction of MAP kinase JNK
2014 - 2018 Control of antigen-specific immune response by nanoparticles and elucidation of its cellular mechanism
2012 - 2015 Role of inflammation in the initiation and development of oral squamous cell carcinoma
2009 - 2011 Characterization of cancer stem cells for oral squamous cell carcinoma cells and its application for treatment of oral carcinoma

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Papers (20)：

Wataru Nishi, Ei Wakamatsu, Hiroaki Machiyama, Ryohei Matsushima, Yosuke Yoshida, Tetsushi Nishikawa, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, et al. Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing "PD-1 Microclusters". Advances in experimental medicine and biology. 2024. 1444. 197-205
Wataru Nishi, Ei Wakamatsu, Hiroaki Machiyama, Ryohei Matsushima, Kensho Saito, Yosuke Yoshida, Tetsushi Nishikawa, Tomohiro Takehara, Hiroko Toyota, Masae Furuhata, et al. Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters. Nature communications. 2023. 14. 1. 3157-3157
H. Toyota, K. Sudo, K. Kojima, N. Yanase, T. Nagao, R. H. Takahashi, H. Iobe, T. Kuwabara, T. Kakiuchi, J. Mizuguchi. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS. 2015. 20. 4. 444-454
HIROKO TOYOTA, NORIKO YANASE, TAKAYUKI YOSHIMOTO, MITSUNORI HARADA, YASUKI KATO, JUNICHIRO MIZUGUCHI. Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo. Oncology Reports. 2015. 33. 1. 292-296
Noriko Yanase, Hiroko Toyota, Kikumi Hata, Seina Yagyu, Takahiro Seki, Mitsunori Harada, Yasuki Kato, Junichiro Mizuguchi. OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis. Vaccine. 2014. 32. 45. 5918-5924

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MISC (16)：

西航, 若松英, 豊田博子, 古畑昌枝, 塚本昌子, 町山裕亮, 西嶋仁, 横須賀忠, 竹原朋宏, 鈴木実. ヒトPD-1/PD-L1抗体のT細胞疲弊解除機能を評価する分子イメージングシステムの確立. 千葉医学雑誌. 2021. 97. 6. 122-122
西航, 若松英, 豊田博子, 古畑昌枝, 塚本昌子, 町山裕亮, 西嶋仁, 横須賀忠, 竹原朋宏, 鈴木実. ヒトPD-1/PD-L1抗体のT細胞疲弊解除機能を評価する分子イメージングシステムの確立. 東京医科大学雑誌. 2021. 79. 1. 114-115
若松英, 町山裕亮, 豊田博子, 古畑昌枝, 秦喜久美, 矢那瀬紀子, 横須賀忠. CD28ファミリー分子によるT細胞の活性化制御. 分子リウマチ治療. 2019. 12
横須賀忠, 若松英, 古畑昌枝, 豊田博子, 秦喜久美, 矢那瀬紀子, 町山裕亮. 分子イメージングから考察した免疫チェックポイント分子のT細胞抑制機構. 臨床免疫・アレルギー科. 2018. 69. 4. 387-394
横須賀忠, 若松英, 古畑昌枝, 豊田博子, 秦喜久美, 矢那瀬紀子, 町山裕亮. すべてはここから始まった、CTLA-4. 実験医学. 2018. 36. 9. 1445-1451

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