Research keywords (6)：
organiser
, cell differentiation
, TKL kinase
, signal transducers and activators of transcription (STAT)
, Dictyostelium discoideum
, long non-coding RNA (lncRNA)
Research theme for competitive and other funds (7)：
2020 - 2023 Regulation of cell differentiation by novel autophagy regulators
2018 - 2022 Establishment of a low-noise live lncRNA detection system and analysis of the lncRNA-proteins complex to elucidate the mechanism for the differentiation switch.
2015 - 2017 真核多細胞微生物の未分化維持に関わる長鎖非コードRNAの動態追跡
2012 - 2016 Analysis of acquisition process of tyrosine kinase during eykaryotic evolution.
2009 - 2011 Functional analyses of cellulase genes in multicellular microbe and application to a new technology
2008 - 2009 Studies on the genomic basis for establishment of multicellular systems using the social amoebae
2005 - 2006 Evolutional analysis of multicellularization in relation to STAT signals by use of Dictyostelium.
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Papers (55)：
Yukika Saga, Yudai Shimoyama, Yoko Yamada, Naoki Morikawa, Takefumi Kawata. The cytosolic lncRNA dutA affects STATa signaling and developmental commitment in Dictyostelium. Genes to Cells. 2022
Yoko Yamada, Gillian Forbes, Qingyou Du, Takefumi Kawata, Pauline Schaap. Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells. Frontiers in Cell and Developmental Biology. 2021. 9. 692473-692473
Romain Bodinier, Ayman Sabra, Jade Leiba, Anna Marchetti, Otmane Lamrabet, Imen Ayadi, Vedrana Fili{\'{c } }, Takefumi Kawata, Igor Weber, Pierre Cosson. Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum. Frontiers in Cell and Developmental Biology. 2021. 9
Romain Bodinier, Jade Leiba, Ayman Sabra, Tania N. Jauslin, Otmane Lamrabet, Cyril Guilhen, Anna Marchetti, Yumi Iwade, Takefumi Kawata, Wanessa C. Lima, et al. LrrkA, a kinase with leucine-rich repeats, links folate sensing with Kil2 activity and intracellular killing. Cellular Microbiology. 2020
Hoshie Iriki, Takefumi Kawata, Tetsuya Muramoto. Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase. PLOS ONE. 2019. 14. 10
