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J-GLOBAL ID：202101018826193085 Update date: Feb. 06, 2025

ishioh masatomo

Research theme for competitive and other funds (3)：

Papers (28)：

Takuya Funayama, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Hiroki Tanaka, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, et al. Splenectomy prevents brain orexin, ghrelin, or oxytocin but not GLP-1-induced improvement of intestinal barrier function in rats. Neurogastroenterology and motility. 2025. 37. 2. e14949
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura. The neurotensin receptor 1 agonist PD149163 alleviates visceral hypersensitivity and colonic hyperpermeability in rat irritable bowel syndrome model. Neurogastroenterology and motility. 2024. 36. 12. e14925
Tsukasa Nozu, Hideyuki Arie, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura. Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models. International immunopharmacology. 2024. 133. 112099-112099
Masatomo Ishioh, Tsukasa Nozu, Saori Miyagishi, Sho Igarashi, Takuya Funayama, Nobuhiro Ueno, Toshikatsu Okumura. Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats. Biochemical pharmacology. 2024. 116201-116201
Masatomo Ishioh, Tsukasa Nozu, Toshikatsu Okumura. Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome. Digestion. 2024. 105. 1. 34-39

MISC (28)：

五十嵐将, 野津司, 石王応知, 船山拓也, 鷲見千紘, 齋藤豪志, 山本昌代, 畑山真弓, 土岐康通, 進藤基博, et al. Ghrelinは中枢神経系に作用して腸管透過性亢進を改善し敗血症死を阻止する. 潰瘍. 2024. 51. 65-65
船山拓也, 野津司, 石王応知, 五十嵐将, 鷲見千紘, 齋藤豪志, 山本昌代, 畑山真弓, 土岐康通, 進藤基博, et al. 腸管透過性制御に関わる脾臓の役割. 潰瘍. 2024. 51. 65-65
石王応知, 粂井志麻, 野津司, 奥村利勝. PGI2はIBSで変容した腸内細菌叢を改善させ、内臓知覚過敏とうつ症状を改善させる. 潰瘍. 2024. 51. 66-66
石王応知, 野津司, 船山拓也, 五十嵐将, 奥村利勝. 消化管疾患と腸管バリア、内臓知覚の最前線脳内ヒスタミン神経系は迷走神経の活性化を介して腸管バリア機能を制御する. 潰瘍. 2024. 51. 67-67
船山拓也, 野津司, 石王応知, 五十嵐将, 鷲見千紘, 齋藤豪志, 山本昌代, 畑山真弓, 土岐康通, 進藤基博, et al. 消化管疾患と腸管バリア、内臓知覚の最前線 GLP-1は中枢神経系に作用してLPSによる腸管透過性亢進を抑制する. 潰瘍. 2024. 51. 67-67

Professional career (1)：

Awards (2)：

2022/09 - 第24回日本神経消化器病学会学会優秀賞 Basal forebrain cholinergic neuron(BFCN)の活性化は迷走神経を介して腸管透過性亢進を改善する。
2022/03 - 第4回機能性腸疾患研究会優秀演題賞脳内orexin, ghrelin, adenosineは迷走神経を介してLeaky gutを改善する

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