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J-GLOBAL ID：202201000049324686 Update date: Feb. 13, 2025

Tokudome Yoshihiro

Research theme for competitive and other funds (4)：

2022 - 2025 ポリイオンコンプレックス技術の最適化による革新的な高分子経皮吸収促進技術の開発
2018 - 2021 Skin lamellar structure of sphingomyelin in epidermis and its effect on skin penetration of compounds
2010 - 2014 Development of novel strategy for fertility preservation using cryopreserved ovarian tissue
2007 - 2008 Development of control type new periodontitis treatment method using of calsium responsible zinc containing nano particle

Papers (76)：

Yukiko Izutsu-Matsumoto, Yuri Okano, Hitoshi Masaki, Yoshihiro Tokudome, Tokuro Iwabuchi. Effect of low humidity on the barrier functions of keratinocytes in a reconstructed human epidermal model. International Journal of Cosmetic Science. 2025
Yoshihiro Tokudome, Asami Sasaki. Influence of Radical Generation and Elimination on Sebum Production of Hamster Sebaceous Gland Cells. Life. 2025
Kei Tsukui, Masamitsu Suzuki, Miyu Amma, Yoshihiro Tokudome. Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation. Bioscience, Biotechnology, and Biochemistry. 2024
Yuko Saeki, Eiko Kato, Yoshihiro Tokudome. A consideration on infinite and finite dosing in skin permeation using reconstructed models,. Skin Pharmacology and Physiology. 2024
Kei Tsukui, Masamitsu Suzuki, Miyu Amma, Yoshihiro Tokudome. Ionic composition of Shotokuseki extract alters cell differentiation and lipid metabolism in three-dimensional cultured human epidermis. Cytotechnology. 2024

MISC (24)：

小見達哉, 杉林堅次, 徳留嘉寛. ポリイオンコンプレックス技術を用いたヒアルロン酸ナノ粒子の皮膚浸透性評価. 日本薬学会年会要旨集. 2015. 135年会. 4. 75-75
中村芳, Wierzba Konstanty, 阿部卓哉, Panthee Suresh, 高橋俊二, 川谷誠, 長田裕之, 杉林堅次, 徳留嘉寛. 長期血中滞留型リベロマイシンA含有リポソームの体内動態. 日本薬学会年会要旨集. 2015. 135年会. 4. 81-81
佐々木麻美, 杉林堅次, 徳留嘉寛. 正常ハムスター皮脂腺細胞の皮脂生成に対する抗酸化物質および酸化物質の影響. 日本薬学会年会要旨集. 2015. 135年会. 3. 54-54
中村芳, Wierzba Konstanty, 阿部卓哉, Panthee Suresh, 高橋俊二, 川谷誠, 長田裕之, 杉林堅次, 徳留嘉寛. リベロマイシンAの体内動態及びリポソーム化の検討. 日本薬剤学会年会講演要旨集. 2014. 29年会. 236-236
徳留嘉寛, 内野翔平, 杉林堅次. グルコシルセラミドリポソームによる皮膚免疫増強効果. 日本薬剤学会年会講演要旨集. 2014. 29年会. 242-242

Professional career (1)：

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