Tokudome Yoshihiro

Research theme for competitive and other funds (4)：

2022 - 2025 ポリイオンコンプレックス技術の最適化による革新的な高分子経皮吸収促進技術の開発
2018 - 2021 Skin lamellar structure of sphingomyelin in epidermis and its effect on skin penetration of compounds
2010 - 2014 Development of novel strategy for fertility preservation using cryopreserved ovarian tissue
2007 - 2008 Development of control type new periodontitis treatment method using of calsium responsible zinc containing nano particle

Papers (64)：

Madoka Kage, Yurina Itaya, Jumpei Horikoshi, Yoshihiro Tokudome. Effect of galactosylceramide on stratum corneum intercellular lipid synthesis in a three-dimensional cultured human epidermis model. Biochemistry and biophysics reports. 2021. 28. 101135-101135
Takenaga Hiranuma, Ken Watanabe, Tadashi Yamashita, Toshiro Okazaki, Yoshihiro Tokudome. Role of collagen degradation pathway in sphingomyelin synthase 2-deficient mouse skin. Biomedical Dermatology. 2021. 5. 1
杉林堅次, 藤井まき子, 徳留嘉寛, 内野智信. フォーカスグループのこれまでの軌跡と今後の展望経皮投与製剤FG. 薬剤学: 生命とくすり. 2021. 81. 4. 264-268
Shota Sakai, Asami Makino, Akihito Nishi, Takeshi Ichikawa, Tadashi Yamashita, Makoto Taniguchi, Yoshihiro Tokudome, Yoshio Hirabayashi, Masashi Akiyama, Debra Crumrine, et al. Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice. Skin Pharmacology and Physiology. 2021. 34. 5. 246-252
Moe Otsuka, Tsuyoshi Tamane, Yoshihiro Tokudome. Effect of Lactic Fermentation Products on Human Epidermal Cell Differentiation, Ceramide Content, and Amino Acid Production. Skin Pharmacology and Physiology. 2021. 34. 2. 103-114

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MISC (24)：

小見達哉, 杉林堅次, 徳留嘉寛. ポリイオンコンプレックス技術を用いたヒアルロン酸ナノ粒子の皮膚浸透性評価. 日本薬学会年会要旨集. 2015. 135年会. 4. 75-75
中村芳, Wierzba Konstanty, 阿部卓哉, Panthee Suresh, 高橋俊二, 川谷誠, 長田裕之, 杉林堅次, 徳留嘉寛. 長期血中滞留型リベロマイシンA含有リポソームの体内動態. 日本薬学会年会要旨集. 2015. 135年会. 4. 81-81
佐々木麻美, 杉林堅次, 徳留嘉寛. 正常ハムスター皮脂腺細胞の皮脂生成に対する抗酸化物質および酸化物質の影響. 日本薬学会年会要旨集. 2015. 135年会. 3. 54-54
中村芳, Wierzba Konstanty, 阿部卓哉, Panthee Suresh, 高橋俊二, 川谷誠, 長田裕之, 杉林堅次, 徳留嘉寛. リベロマイシンAの体内動態及びリポソーム化の検討. 日本薬剤学会年会講演要旨集. 2014. 29年会. 236-236
徳留嘉寛, 内野翔平, 杉林堅次. グルコシルセラミドリポソームによる皮膚免疫増強効果. 日本薬剤学会年会講演要旨集. 2014. 29年会. 242-242

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