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J-GLOBAL ID：202201000289095528   Update date: Mar. 02, 2025

Irie Naoko

イリエ ナオコ | Irie Naoko
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Affiliation and department：
Central Institute for Experimental Medicine and Life Science (CIEM) Metabolic Systems Laboratory, Bioimaging Center

About Central Institute for Experimental Medicine and Life Science (CIEM) Metabolic Systems Laboratory, Bioimaging Center


Job title： Principal Investigator
Research field  (3)： Molecular biology ,  Developmental biology ,  Cell biology
Research keywords  (11)： Human germ cell development ,  Primordial germ cells ,  Human pluripotent stem cell ,  ES cell ,  iPS cell ,  Transcription Factor ,  Epigenetics ,  DNA methylation ,  Human early develpment ,  Metabolism ,  Functional Genomic Screening
Research theme for competitive and other funds  (19)：
  • 2024 - 2029 酸素濃度依存的ヒト胚発生分子機構と着床における役割の解明
  • 2023 - 2028 Role and mechanism of DNA hypomethylation during human early development
  • 2024 - 2027 代謝の操作:ヒト初期胚に学ぶ代謝スイッチの探索
  • 2024 - 2026 発生初期ヒト胚細胞の酸素濃度感知システムと着床妊娠成立における役割の解析
  • 2024 - 2026 Molecular cross-talk between the epigenetic and metabolic reprogramming during early human
Show all
Papers (23)：
  • Naoko Irie, Toshihiro Kobayashi, M Azim Surani. Human Primordial Germ Cell-Like Cell Induction from Pluripotent Stem Cells by SOX17 and PRDM1 Expression. Methods in molecular biology (Clifton, N.J.). 2024. 2770. 87-97
  • Naoko Irie, Sun-Min Lee, Valentina Lorenzi, Haiqi Xu, Jinfeng Chen, Masato Inoue, Toshihiro Kobayashi, Carmen Sancho-Serra, Elena Drousioti, Sabine Dietmann, et al. DMRT1 regulates human germline commitment. Nature Cell Biology. 2023. 25. 10. 1439-1452
  • Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred W C Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead, et al. Author Correction: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos. Nature cell biology. 2023. 25. 1. 194-194
  • Walfred W C Tang, Aracely Castillo-Venzor, Wolfram H Gruhn, Toshihiro Kobayashi, Christopher A Penfold, Michael D Morgan, Dawei Sun, Naoko Irie, M Azim Surani. Sequential enhancer state remodelling defines human germline competence and specification. Nature cell biology. 2022. 24. 4. 448-460
  • Jan Willem Bruggeman, Naoko Irie, Paul Lodder, Ans M M van Pelt, Jan Koster, Geert Hamer. Tumors Widely Express Hundreds of Embryonic Germline Genes. Cancers. 2020. 12. 12
ｍore...
Education (3)：
  • 2006 - 2010 Keio University
  • 2004 - 2006 Keio University
  • 2000 - 2004 Kitasato University
Professional career (1)：
  • PhD (Keio University)
Work history (7)：
  • 2023 - 現在 Central Institute for Experimental Medicine and Life Science (CIEM) Metabolic Systems Laboratory, Bioimaging Center Principal Investigator
  • 2022 - 2023 Keio University School of Medicine Department of Biochemistry
  • 2018 - 2022 University of Cambridge Gurdon Institute Senior Research Fellow
  • 2012 - 2018 University of Cambridge Gurdon Institute Research Fellow
  • 2011 - 2012 University of Cambridge Gurdon Institute
Show all
Awards (2)：
  • 2024 - Japan Society for the Promotion of Science (JSPS) JSPS Prize Research on Human Early Germline Development
  • 2017 - Medical Research Council (MRC) Research Grant Award Human Germline In Vitro Models for Development and the Epigenetic Program
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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