Rchr
J-GLOBAL ID：202201001446618935
Update date: Oct. 08, 2024
Meguro Kazuyuki
メグロ カズユキ | Meguro Kazuyuki
Affiliation and department：
Job title：
Assistant professor/Lecturer
Research field (2)：
Genomics
, Allergies and connective tissue disease
Research keywords (1)：
Immunodysregulation, Clinical genomics, Autoinflammatory diseases, Immunodeficiency
Research theme for competitive and other funds (1)：
- 2016 - 2018 iTR35細胞の分化機構及び関節リウマチにおける役割の解明
Papers (18)：
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Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Yamina A Berchiche, D Eric Anderson, Kirk M Druey, Judith N Mandl, Bertrand Isidor, et al. Germline mutations in a G protein identify signaling cross-talk in T cells. Science (New York, N.Y.). 2024. 385. 6715. eadd8947
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Shunjiro Kurihara, Kotaro Suzuki, Masaya Yokota, Takashi Ito, Yuki Hayashi, Ryo Kikuchi, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, et al. Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells. Biomolecules. 2024. 14. 1. 89-89
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Shigeru Tanaka, Keishi Etori, Koto Hattori, Jun Tamura, Kei Ikeda, Takahiro Kageyama, Kazuyuki Meguro, Taro Iwamoto, Arifumi Iwata, Shunsuke Furuta, et al. CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance. Modern rheumatology. 2023
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Kazuma Iida, Kensuke Suga, Kotaro Suzuki, Shunjiro Kurihara, Yoko Yabe, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Akira Suto, et al. A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development. Biochemical and Biophysical Research Communications. 2023. 664. 9-19
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Yusuke Yokoyama, Tomohiro Tamachi, Arifumi Iwata, Yuko Maezawa, Kazuyuki Meguro, Masaya Yokota, Hiroaki Takatori, Akira Suto, Kotaro Suzuki, Koichi Hirose, et al. A20 (Tnfaip3) expressed in CD4+ T cells suppresses Th2 cell-mediated allergic airway inflammation in mice. Biochemical and Biophysical Research Communications. 2022
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MISC (8)：
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横山 裕亮, 玉地 智宏, 岩田 有史, 前澤 裕子, 目黒 和行, 横田 雅也, 高取 宏昌, 須藤 明, 鈴木 浩太郎, 廣瀬 晃一, et al. 動物モデル 気道炎症 CD4陽性T細胞に発現するA20はTh2型アレルギー性気道炎症を抑制する. アレルギー. 2017. 66. 4-5. 606-606
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目黒 和行, 中島 裕史. 【免疫疾患の分子標的療法】アレルギー疾患に対する分子標的療法. 炎症と免疫. 2016. 24. 6. 507-512
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福田匡志, 末廣健一, 目黒和行, 古田俊介, 池田啓, 廣瀬晃一, 中島裕史. 脳生検を施行するも急性型中枢神経病変の鑑別に苦慮した不全型Behcet病の一例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2016. 60th. 538-538
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K. Meguro, K. Suzuki, J. Hosokawa, Y. Sanayama, S. Tanaka, S. Furuta, K. Ikeda, H. Takatori, A. Suto, O. Ohara, et al. ROLES OF B CELL LEUKEMIA/LYMPHOMA 3 IN THE DEVELOPMENT OF T FOLLICULAR HELPER CELLS AND THE PATHOGENESIS OF RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. 2015. 74. 113-114
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中込 大樹, 鈴木 浩太郎, 目黒 和行, 細川 淳一, 中島 裕史. マスト細胞 接触過敏症におけるマスト細胞産生性IFN-γの役割. アレルギー. 2013. 62. 9-10. 1285-1285
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Books (1)：
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エッセンシャル免疫学(第4版)
メディカル・サイエンス•インターナショナル 2023
Lectures and oral presentations (7)：
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Unwinding the molecular pathogenesis of a novel inherited immunodysregulatory disorder caused by loss-of-function mutations in DExD/H box helicase SBNO2
(The 5th Asia-Pacific Society for Immunodeficiency (APSID) Congress 2024)
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Clinical genomics of rare immune diseases reveals new molecular mechanisms in host defenses
(cMAV-cSIMVa Workshop 2024)
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Whole-exome sequencingを用いた遺伝性免疫異常症の診断と病態生理の解明
(Rare Disease Seminar PID患者の移行期医療について考える 2023)
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SBNO2 deficiency, a novel inherited immunodysregulatory syndrome, reveals new molecular mechanisms in host defenses.
(The 9th Global Network Forum on Infection and Immunity: Neo Mycology 2023)
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Unwinding the molecular pathogenesis of a novel inherited immunodysregulatory disorder caused by loss-of-function mutations in DExD/H box helicase SBNO2
(The 51st Annual Meeting of the Japanese Society for Immunology 2022)
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Education (3)：
- - 2015 Chiba University
- - 2008 Chiba University School of Medicine
- - 2004 Keio University Graduate School of Science and Technology
Professional career (1)：
- M.D., Ph.D. (Chiba University)
Committee career (2)：
- 2023/04 - 現在 Nagoya University IRUD expert pannel
- 2022/04 - 現在 Chiba University Hospital IRUD (Initiative on Rare and Undiagnosed Diseases) Comittee
Awards (4)：
- 2024/07 - 千葉大みらい医療基金 千葉大みらい医療基金医学研究助成 免疫疾患患者の全エクソーム配列解析から着想を得た新規自己免疫疾患治療薬の開発
- 2023/08 - Takeda Science Foundation Takeda Science Foundation Research Grant (Clinical medicine)
- 2023/05 - The Japanese Society of Clinical Immunology The 2nd International Symposium of Clinical Immunology, Young Investigator's Poster Award (Clinical) Identification of a novel inherited immunodysregulatory disorder caused by loss-of-function mutations in DExD/H box helicase SBNO2 and its molecular pathogenesis
- 2022/07 - National Institutes of Health Fellows Award for Research Excellence 2023
Association Membership(s) (7)：
Japanese Society for Immunodeficiency and Autoinflammatory Diseases
, The Japan Society of Human Genetics
, The Japanese Society of Clinical Immunology
, Japanese Society for Immunology
, Japanese Society of Allergology
, Japan College of Rheumatology
, The Japanese Society of Internal Medicine
