Okamura Kazuyuki

オカムラカズユキ | Okamura Kazuyuki

Affiliation and department：
Job title： Senior Resercher

Research field (1)： Hygiene and public health (laboratory)

Research keywords (6)： arsenic , cellular senescence , cancer , epigenetics , DNA methylation , transgenerational effect

Research theme for competitive and other funds (7)：

2021 - 2025 Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
2018 - 2021 The mechanisms of arsenic-induced carcinogenesis via fibroblast senescence
2015 - 2018 The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
2015 - 2017 Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatin tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant mice
2014 - 2017 Studies on epimutations that are involved in multigenerational effects of environmental chemicals in mice

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Papers (16)：

Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara. Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells. Toxicology and applied pharmacology. 2022. 454. 116231-116231
Kota Kato, Kazuyuki Okamura, Kyoshiro Hiki, Hiroyuki Kintsu, Keiko Nohara, Takahiro Yamagishi, Nobuyoshi Nakajima, Haruna Watanabe, Hiroshi Yamamoto. Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna. Aquatic toxicology (Amsterdam, Netherlands). 2022. 243. 106071-106071
Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura. Gestational arsenic exposure and paternal intergenerational epigenetic inheritance. Toxicology and applied pharmacology. 2020. 409. 115319-115319
Keiko Nohara, Kazuhiko Nakabayashi, Kazuyuki Okamura, Takehiro Suzuki, Shigekatsu Suzuki, Kenichiro Hata. Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice. Epigenetics & chromatin. 2020. 13. 1. 53-53
Kazuyuki Okamura, Takehiro Suzuki, Keiko Nohara. Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways. Toxicology and applied pharmacology. 2020. 408. 115259-115259

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Lectures and oral presentations (35)：

妊娠期無機ヒ素曝露によって孫世代の精子に伝達される遺伝子領域のDNAメチル化変化
(日本衛生学雑誌 2022)
ヒト肝細胞株Huh7において無機ヒ素曝露は細胞老化およびSASP因子の亢進を誘導する
(日本衛生学雑誌 2022)
環境・衛生部会若手研究者シンポジウム〜解明が進む環境汚染物質による毒性発現機序〜無機ヒ素曝露による多世代影響のメカニズム解明に向けた現在までの取り組み
(日本薬学会年会要旨集 2022)
ヒト皮膚線維芽細胞HFb16dにおける無機ヒ素曝露による細胞老化の誘導とSASP因子の亢進
(第44回日本分子生物学会年会 2021)
無機ヒ素曝露によって誘導されたヒト肝星細胞LX-2の細胞老化ではSASP因子が増加し、曝露を中止しても高発現が維持される
(The Journal of Toxicological Sciences 2021)

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Work history (5)：

Awards (5)：

Association Membership(s) (8)：

日本基礎老化学会 , 老化促進モデルマウス(SAM)学会 , 日本ヒ素研究会 , 日本毒性学会 , 日本免疫毒性学会 , 日本分子生物学会 , 日本癌学会 , 日本衛生学会

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