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J-GLOBAL ID:202201004511154550   Update date: Dec. 19, 2022

Matsui Aya

マツイ アヤ | Matsui Aya
Affiliation and department:
Research field  (2): Morphology, anatomy ,  Tumor biology
Research keywords  (1): 血管形態、血管生理、腫瘍血管正常化、腫瘍免疫、腫瘍微小環境、転移
Research theme for competitive and other funds  (2):
  • 2017 - 2018 血管形成におけるCXCL17とMDSCの新たな相互作用の解析
  • 2014 - 2017 CXCL17反応性の好中球型免疫抑制細胞の形態学的解析と新たな抗腫瘍戦略への応用
Papers (11):
  • Kikuchi H, Matsui A, Morita S, Amoozgar Z, Inoue K, Ruan Z, Staiculescu D, Wong JS, Huang P, Yau T, et al. Increased CD8+ T-Cell Infiltration and Efficacy for Multikin ase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma. J Natl Cancer Inst. 2022. 114. 9. 1301-1305
  • Xiao Y, Chen J, Zhou H, Zeng X, Ruan Z, Pu Z, Jiang X, Matsui A, Zhu L, Amoozgar Z, et al. Combining p53 mRNA nanotherapy with immune checkpoint bl ockade reprograms the immune microenvironment for effective cancer therapy. Nat Commun. 2022. 13. 1. 758
  • Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, et al. Placental growth factor promotes tumor desmoplasia and treatment-resistance in intrahepatic cholangiocarcinoma. Gut. 2021. 71. 1. 185-193
  • Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, et al. Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. J Immunother Cancer. 2020. 8. 2. e001435
  • Shigeta K, Datta M, Hato T, Kitahara S, Chen I, Matsui A, Kikuchi H, Mamessier E, Aoki S. Huang P, Zhu A, et al. Dual PD-1 and VEGFR-2 blockade promote vascular normalization and enhances anti-tumor immune responses in HCC. Hepatology. 2020. 71. 4. 1247-1261
more...
MISC (3):
  • 癌治療の鍵となる腫瘍内微小環境のリプログラミング. Medical Science Digest. 2021. 47. 10. 454-459
  • Matsui A, Murakami T. CXCL17 (chemokine (C-X-C motif) ligand 17). Atlas Genet. Cytogent Oncol. Haematol. 2015. 19. 97-101
  • 悪性黒色腫の転写制御による免疫学的感受性の増幅. Biotherapy. 2011. 25. 4. 756-761
Lectures and oral presentations  (9):
  • Evaluation of TNBC metastasis suppression by combination therapy of molecular targeted drug and immunotherapy
    (Tumor Biology in HMS/MGH 2022)
  • 最新のXR (クロス・リアリティ) がつなぐ若手がん研究者の近未来
    (第80回日本癌学会学術総会シンポジウム 2021)
  • Combining Regorafenib and PD1 blockade increases CD8 T-cell filtration by inducing CXCL10 expression in hepatocellular carcinoma.
    (The 72nd MGH Scientific Advisory Committee Meeting 2021)
  • CXCL17 and G-MDSCs involved in tumor angiogenesis.
    (Tumor Biology in HMS/MGH 2016)
  • CXCL17が及ぼす腫瘍血管の形態変化について
    (第2回血管生物医学会若手研究会 2016)
more...
Education (3):
  • 2013 - 2017 東京女子医科大学大学院 医学研究科博士課程 解剖学・形態学系専攻
  • 2008 - 2010 Jichi Medical University
  • 2004 - 2008 Teikyo University Faculty of Science and Engineering Department of Biosciences
Professional career (1):
  • 博士(医学)
Work history (6):
  • 2022/05 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Medicine
  • 2017/04 - 2022/05 Harvard Medical School / Massachusetts General Hospital Department of Radiation Oncology Research Fellow
  • 2014/04 - 2017/03 Japan Society for the Promotion of Science
  • 2012/06 - 2013/03 Tokyo Women's Medical University
  • 2011/04 - 2012/05 Takasaki University of Health and Welfare Faculty of Pharmacy Department of Pharmacy
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Association Membership(s) (4):
日本解剖学会 ,  日本女性科学者の会 ,  日本血管生物医学会 ,  日本癌学会
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