Okamoto Mizuho

オカモトミズホ | Okamoto Mizuho

Affiliation and department：
Job title： Assistant professor

Research field (2)： Molecular biology , Molecular biology

Research theme for competitive and other funds (2)：

2024 - 2028 家族性拡張型心筋症モデルにおける運動療法の効果
2023 - 2026 ヒトiPS細胞由来神経細胞におけるCa2+異常波とアルツハイマー病発生メカニズムの関連

Papers (9)：

Atsushi Hori, Haruka Inaba, Takashi Hato, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, Shusuke Mori, et al. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease. PloS one. 2024. 19. 8. e0291887
Rena Okuizumi, Riku Harata, Mizuho Okamoto, Seiji Sato, Kyosuke Sugawara, Yukina Aida, Akari Nakamura, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba. Resveratrol is converted to the ring portion of coenzyme Q10 and raises intracellular coenzyme Q10 levels in HepG2 cell. Journal of Clinical Biochemistry and Nutrition. 2024
Akari Nakamura, Yukina Aida, Mizuho Okamoto, Ayaka Maeda, Ayaka Nagao, Kanae Kitatani, Susumu Takekoshi, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba. Transferrin, insulin, and progesterone modulate intracellular concentrations of coenzyme Q and cholesterol, products of the mevalonate pathway, in undifferentiated PC12 cells. Journal of clinical biochemistry and nutrition. 2023. 72. 3. 199-206
Hikaru Takeuchi, Kyosuke Sugawara, Mizuho Okamoto, Akari Nakamura, Tsukika Tanaka, Yui Fujita, Kaiho Ishiguro, Hana Yamazaki, Maiko Okada, Akane Mikami, et al. Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency. Journal of clinical biochemistry and nutrition. 2022. 71. 2. 97-102
Akari Nakamura, Mizuho Okamoto, Ayaka Maeda, Huiyu Jiang, Kyosuke Sugawara, Kanae Kitatani, Susumu Takekoshi, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba. Cellular level of coenzyme Q increases with neuronal differentiation, playing an important role in neural elongations. Journal of clinical biochemistry and nutrition. 2022. 71. 2. 89-96

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MISC (22)：

岡本瑞穂, 奥泉怜奈, 蛭田紗生, 須賀祐輔, 中村朱里, 山本順寛, 藤沢章雄, 加柴美里. ミトコンドリアDNA低下細胞株のCoenzyme Q10増加機構の解明. ビタミン. 2024. 98. 4. 243-243
會田有希奈, 岡本瑞穂, 中村朱里, 前田彩樺, 藤沢章雄, 山本順寛, 加柴美里. 神経細胞のコエンザイムQ量変動メカニズムの解明. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2P-227]
奥泉伶菜, 原田陸, 岡本瑞穂, 藤沢章雄, 山本順寛, 加柴美里. レスベラトロール,インスリン,プロゲステロン投与による細胞内コエンザイムQ10量制御手法の確立. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2P-462]
奥泉伶菜, 岡本瑞穂, 原田陸, 中村朱里, 藤沢章雄, 山本順寛, 加柴美里. 細胞内コエンザイムQ10量制御におけるSirtuin1の役割の解明. 日本酸化ストレス学会学術集会プログラム・抄録集. 2023. 76th
原田陸, 奥泉伶菜, 中村朱里, 岡本瑞穂, 山本順寛, 藤沢章夫, 加柴美里. レスベラトロール投与によるコエンザイムQ10量の制御. 日本酸化ストレス学会学術集会プログラム・抄録集. 2023. 76th

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Education (1)：

2019 - 2022 Tokyo University of Technology

Professional career (1)：

Doctor of Engineering (Tokyo University of Technology)

Work history (4)：

2024/09 - 現在 Tokyo Metropolitan Institute of Medical Science Diabetic Neuropathy Project
2023/09 - 現在 Tokyo University of Technology School of Bioscience and Biotechnology Department of Bioscience and Biotechnology Assistant professor
2022/04 - 2023/08 Tokyo University of Technology
2022/04 - 2023/08 順天堂大学ゲノム・再生医療センター臨床検査医学講座博士研究員

Awards (3)：

2021/05 - 第74回日本酸化ストレス学会第21回日本NO学会合同学術集会口演優秀賞ミトコンドリアDNA量低下株のミトコンドリア制御機構の解析
2021/03 - 20th Biennial Meeting of SFRR International. SFRR International 2021 Young Investigator Award. An increase in mitochondrial DNA copy number was observed in monocyte cell line differentiated into macrophages but not in mitochondrial respiratory protein mRNA levels and TFAM.
2019/12 - 9th meeting of SFRR(A+J) young investigator award Establishment of long-term coenzyme Q10 deficient cell model.

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