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J-GLOBAL ID：202201011696007821 Update date: Mar. 19, 2025

Mimura Junsei

Research field (1)： Molecular biology

Research keywords (3)： Oxidative stress , ATF4 , Nrf2

Research theme for competitive and other funds (5)：

2013 - 2018 Analysis of novel oxidative stress response mechanism via ribosome
2012 - 2013 Nrf2 activation mechanism mediated by amino acid starvation response factor GCN1L1
2008 - 2012 Transcriptional regulation by reactive oxygen species
2010 - 2011 Analysis of Nrf2 function in cytokine network regulation
2005 - 2005 AhRとAhRRのXREを介した転写制御における機能相関

Papers (32)：

Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura, Ken Itoh. Emerging Role of GCN1 in Disease and Homeostasis. International journal of molecular sciences. 2024. 25. 5
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota Tatara, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, et al. Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice. International journal of molecular sciences. 2022. 23. 15
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, et al. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. International journal of molecular sciences. 2022. 23. 6
Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh. JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis. FEBS open bio. 2020. 10. 12. 2771-2779
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, et al. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLoS genetics. 2020. 16. 4. e1008693

MISC (3)：

Michiko Tsushima, Junsei Mimura, Jun Liu, Hiromi Yamazaki, Shuya Kasai, Hirofumi Tomita, Ken Itoh. Deficiency of P62/SQSTM1 Exacerbates Doxorubicin-Induced Cardiac Dysfunction. CIRCULATION. 2019. 140
Ken Itoh, Junsei Mimura, Peng Ye, Hidemi Yoshida, Kunio Kosaka. DEVELOPMENT OF A NOVEL NEUROPROTECTIVE STRATEGY BY THE COOPERATIVE TRANSCRIPTIONAL NETWORK CENTERED ON Nrf2. FREE RADICAL BIOLOGY AND MEDICINE. 2014. 76. S7-S7
Ken Itoh, Junsei Mimura, Masayuki Yamamoto. Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview. ANTIOXIDANTS & REDOX SIGNALING. 2010. 13. 11. 1665-1678

Education (3)：

1995 - 1998 Tohoku University Graduate School of Science Department of Chemistry
1993 - 1995 Tohoku University Graduate School of Science Department of Chemistry
1989 - 1993 Tohoku University Faculty of Science

Work history (5)：

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