Research keywords (2)：
慢性閉塞性肺疾患(COPD)
, Respiratory Medicine
Research theme for competitive and other funds (18)：
2019 - 2024 Five-year follow-up of postoperative functional disability and evaluation of the efficacy of prehabilitaion program
2020 - 2023 An attempt to establish a method to evaluate alveolar repair mechanisms comparing human emphysema CT images and mouse experiments
2017 - 2021 Variety of Sleep Disordered Breathing in Multiple System Atrophy - Road Ahead to Achieve Better Mortality with Sophisticated Respiratory Care -
2016 - 2020 Novel therapeutic strategy to attenuate systemic inflammation of patients with COPD
2016 - 2020 resting breathing instability during wakefulness is a novel predictor of clinical outcome in chronic obstructive pulmonary disease
2016 - 2020 The role of autophagy on Gut-lung axis in chronic obstructive pulmonary disease
2015 - 2018 Why is there an area priority during development of emphysema and fibrosis in the human lung? Approach to elucidate the mechanisms by mechanical property of the lung
2013 - 2016 Personalized Therapy According to the Phenotype of Obstructive Sleep Apnea - Exploring the Efficacy of the Pharmacological Therapy -
2012 - 2016 Novel strategy of nutritional intervention for preventing progress and onset of COPD
2012 - 2015 A search for determinants of phenotypes in chronic obstructive pulmonary disease; by a collaborative research in Japan and U.S.
2011 - 2015 The decreases in hypoxic ventilatory response affect acute exacerbation in patients with respiratory failure and/or obesity hypoventilation syndrome
2011 - 2013 The changes in the collagen fiber orientation by aging: an approach to the mechanism of repture of alveolar wall
2008 - 2010 Three dimensional analysis for collagen fiber orientation in the human lung to investigate how the lung can maintain its structure under mechanical load by respiration.
2008 - 2010 'The lung- gut network'contributes to development of chronic obstructive pulmonary disease (COPD).
2007 - 2009 Hypoxic stress in sleep apnea causes systemic inflammation and promotes atherosclerosis.
2006 - 2007 A trial to evaluate the mechanical anisotropy in human lung ; Aim for elucidating why centrilobular type emphysema occurs predominantly at upper lung
2003 - 2004 Hypoxic stress and atherosclerosis in patients with sleep apnea-hypopnea syndrome
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Papers (242)：
Fujita Y, Yamauchi M, Uyama H, Oda H, Igaki M, Yoshikawa M, Kimura H. The effects of heated humidification to nasopharynx on nasal resistance and breathing pattern. PLOS ONE. 2019
Uyama H, Yamauchi M, Fujita Y, Yoshikawa M, Ohnishi Y, Kimura H. The effects of arousal accompanying an apneic event on blood pressure and sympathetic nerve activity in severe obstructive sleep apnea. Sleep Breath. 2018. 22. 1. 149-155
Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, et al. Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc. 2017
