Watanabe Kengo

ワタナベケンゴ | Watanabe Kengo

Affiliation and department：
Job title： K. Carole Ellison Fellow in Bioinformatics

Research field (6)： Pharmaceuticals - health and biochemistry , Cell biology , Functional biochemistry , Molecular biology , Nutrition and health science , Biological, health, and medical informatics

Research keywords (18)： Multiomic analysis , Systems biology , Machine learning , Wellness , Obesity , BMI , Aging , Stress , Signal transduction , Phase separation , Biomolecular condensates , Cell volume regulation , Cell death , ASK family , MAP kinase , Protein phosphatase , NAD , Poly(ADP-ribose)

Research theme for competitive and other funds (4)：

2023 - 2027 An exploration for the aging-accompanying state transitions of organismal molecular systems
2019 - 2020 An exploration of the common principles in the cellular osmotic stress response and cell death induction
2017 - 2019 Genome-wide screen-based identification of non-selective hypertonicity-induced cation channel
2014 - 2016 浸透圧の認識から解読へ至る細胞内分子機構

Papers (21)：

Adam R Burns, Jack Wiedrick, Alicia Feryn, Michal Maes, Mukul K Midha, David H Baxter, Seamus R Morrone, Timothy J Prokop, Charu Kapil, Michael R Hoopmann, et al. Proteomic changes induced by longevity-promoting interventions in mice. GeroScience. 2024. 46. 2. 1543-1560
Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G Garcia, Michael R Hoopmann, Mukul K Midha, David H Baxter, Michal Maes, Seamus R Morrone, et al. Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers. Communications Biology. 2023. 6. 1. 768
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo. Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress. bioRxiv. 2023
Noa Rappapor, Kengo Watanabe. Biological BMI uncovers hidden health risks and is more responsive to lifestyle shifts. Nature Medicine. 2023. 29. 4. 801-802
Kazuhiro Morishita, Kengo Watanabe, Isao Naguro, Hidenori Ichijo. Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response. Cell Reports. 2023. 112315

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MISC (4)：

Noa Rappaport, Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Leroy Hood, Nathan Price, Cory Funk, Priyanka Baloni. BIOLOGICAL AGING AND APOE STATUS REWIRE INTER-OMIC ASSOCIATIONS RELATED TO BIOENERGETICS IN HUMANS. Innovation in Aging. 2023. 7. Supplement_1. 631-632
Lance Pflieger, Kengo Watanabe, Max Robinson, Gustavo Glusman, Jodi Lapidus, Oliver Fiehn, Robert Moritz, Noa Rappaport. PROSPECTIVE MULTI-OMIC ANALYSIS OF HUMAN LONGEVITY COHORTS IDENTIFIES ANALYTE NETWORKS ASSOCIATED WITH LONGEVITY. Innovation in Aging. 2023. 7. Supplement_1. 691-692
Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Oliver Fiehn, Robert Moritz, Richard Miller, Noa Rappaport. MULTIOMIC SYSTEMS ANALYSIS OF LIFESPAN-EXTENDING INTERVENTIONS IN MOUSE TISSUES. Innovation in Aging. 2023. 7. Supplement_1. 934-934
Kengo Watanabe, Tomasz Wilmanski, Lance Pflieger, Christian Diener, John Earls, Jennifer Hadlock, Jennifer Lovejoy, Sean Gibbons, Andrew Magis, Leroy Hood, et al. Characterization of Blood Multiomics-Based Metabolic Health Measure. Obesity. 2023. 31. S2. 259-259

Books (4)：

Osmosensing via liquid-liquid phase separation (BIO Clinica Vol.38 No.4)
2023
Quantitative evaluation of liquid droplets using image analysis (Jikkenigaku Bessatsu - Phase Separation Analysis Protocol)
2022 ISBN:9784758122597
Cells sense osmotic stress from the inside through liquid-liquid phase separation (Jikkenigaku Vol.39 No.11)
2021 ISBN:9784758125451
A high-content genome-wide siRNA screening for signal transduction research (Jikkenigaku Vol.32 No.9)
2014 ISBN:9784758101288

Lectures and oral presentations (9)：

Rise of the age of discovery in health science researches
(The 32nd Young Talent Development Seminar (COI-NEXT integrated health industry city site that will be a world model for self-sustained growth of human resources and technology) 2024)
Beyond the Scale with Biological BMI: Integrated Multiomic Measures of Metabolic Health
(Oike Lab seminar (Kumamoto University) 2023)
Rise of the age of discovery in stress response researches
(Nex-Gen Symposium on Cell Signaling 2023)
Beyond the Scale with Biological BMI: Integrated Multiomic Measures of Metabolic Health
(RIKEN BDR seminar 2023)
Beyond the Scale with Biological BMI: Integrated Multiomic Measures of Metabolic Health
(Long Lab seminar (Vanderbilt University Medical Center) 2023)

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Education (5)：

2012 - 2015 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences (PhD)
2012 - 2012 Cold Spring Harbor Laboratory Computational Cell Biology (course program)
2010 - 2012 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences (MS)
2007 - 2010 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2006 - 2007 The University of Tokyo College of Arts and Sciences

Professional career (1)：

PhD in Pharmaceutical Sciences (The University of Tokyo)

Work history (8)：

2021/12 - 現在 Institute for Systems Biology The Hood-Price Lab for Systems Biomedicine K. Carole Ellison Fellow in Bioinformatics
2020/12 - 2021/11 Institute for Systems Biology The Hood-Price Lab for Systems Biomedicine, Institute for Systems Biology Postdoctoral Fellow
2019/11 - 2020/11 Institute for Systems Biology The Hood-Price Lab for Systems Biomedicine, Institute for Systems Biology Visiting Scientist
2016/04 - 2019/11 The University of Tokyo Graduate School of Pharmaceutical Sciences Project Assistant Professor
2015/04 - 2016/03 The University of Tokyo Graduate School of Pharmaceutical Sciences JSPS Research Fellow (PD)

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Committee career (1)：

2023/07 - 現在 Frontiers in Systems Biology (Systems Concepts, Theory and Policy in Biology and Medicine) Review Editor

Awards (11)：

2021/12 - Institute for Systems Biology K. Carole Ellison Fellowship
2020/12 - The Uehara Memorial Foundation Postdoctoral Fellowship for Study Abroad
2019/11 - The Nakatomi Foundation Overseas Research Fellowship
2019/11 - The Japanese Biochemical Society The Osamu Hayaishi Memorial Scholarship for Study Abroad
2018/06 - The 10th Signal Network Meeting Excellent Presentation Award

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Association Membership(s) (3)：

The Molecular Biology Society of Japan , The Japanese Biochemistry Society , The Japanese Society of Cell Death Research

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