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J-GLOBAL ID：202301015528900092   Update date: Feb. 17, 2025

Kubota Hisayoshi

クボタ ヒサヨシ | Kubota Hisayoshi
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Affiliation and department：
Fujita Health University Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS)

About Fujita Health University Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS)


Job title： Assistant professor
Homepage URL  (1)： https://www.fujita-hu.ac.jp/icbs/behav-neuropharmacol/
Research field  (1)： Psychiatry
Research keywords  (10)： Behavioral Pharmacology ,  Psychiatric Disease ,  Neurodegenerative Disease ,  Drug Dependence ,  Schizophrenia ,  Bipolar disorder ,  Parkinson's disease ,  Alzheimer's disease ,  Decision-making ,  Empathy
Research theme for competitive and other funds  (3)：
  • 2024 - 2027 パーキンソン病における意思決定障害の分子・神経メカニズム解明と新規治療薬開発
  • 2024 - 2026 包括的フォワード・ケモジェネティクス法による共感性の神経メカニズムの解明
  • 2024 - 2025 向社会的行動を司る共感性の神経基盤の探索
Papers (15)：
  • Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, et al. Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine-3-monooxygenase with microglial decline. British Journal of Pharmacology. 2024
  • Masaya Hasegawa, Moe Niijima, Kazuo Kunisawa, Tomoaki Teshigawara, Hisayoshi Kubota, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Hyoung-Chun Kim, Kuniaki Saito, et al. Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta. Biochemical and Biophysical Research Communications. 2024. 737. 150922-150922
  • Moeka Tanabe, Kazuo Kunisawa, Imari Saito, Aika Kosuge, Hiroyuki Tezuka, Tomoki Kawai, Yuki Kon, Koyo Yoshidomi, Akari Kagami, Masaya Hasegawa, et al. Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine. Molecular Psychiatry. 2024
  • Hitomi Kurahashi, Kazuo Kunisawa, Kenji F. Tanaka, Hisayoshi Kubota, Masaya Hasegawa, Mai Miyachi, Yuka Moriya, Yoichi Hasegawa, Taku Nagai, Kuniaki Saito, et al. Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid. Neuropsychopharmacology. 2024
  • Rinako Tanaka, Jingzhu Liao, Yue Liu, Wenjun Zhu, Kisa Fukuzawa, Masamichi Kondo, Masahito Sawahata, Daisuke Mori, Akihiro Mouri, Hisayoshi Kubota, et al. Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia. 2024
ｍore...
MISC (13)：
  • 田辺萌夏, 田辺萌夏, 國澤和生, 齋藤いまり, 小菅愛加, 河合智貴, 窪田悠力, 齋藤邦明, 齋藤邦明, 齋藤邦明, et al. Social isolation in childhood induces abnormalities of gut microbiota composition and spatial cognitive impairment. 腸内細菌学雑誌. 2023. 37. 2
  • 國澤和生, 田辺萌夏, 齋藤いまり, 小菅愛加, 河合智貴, 窪田悠力, 齋藤邦明, 齋藤邦明, 鍋島俊隆, 鍋島俊隆, et al. レパミピドは大腸杯細胞の増殖を促し,社会的隔離ストレスによる行動異常を緩解する. 日本生理学雑誌(Web). 2023. 85. 3
  • 長谷川眞也, 毛利彰宏, 毛利彰宏, 國澤和生, 窪田悠力, 倉橋仁美, 小菅愛加, 山本康子, 齋藤邦明, 齋藤邦明, et al. ミクログリア由来キヌレニン-3-モノオキシゲナーゼの発現低下に関連したキヌレン酸の増加は慢性予測不能軽度ストレスによるうつ様行動およびHPA系の調節不全に関与する. 日本神経化学会大会抄録集(Web). 2022. 65th
  • 山岸周平, 毛利彰宏, 毛利彰宏, 國澤和生, 小菅愛加, 窪田悠力, 倉橋仁美, 長谷川眞也, 山本康子, 齋藤邦明, et al. Disruption of the blood-placental barrier by maternal immune activation via indoleamine-2,3 dioxygenase-1 is involved in neurodevelopmental impairments of offsprings. 日本生物学的精神医学会(Web). 2022. 44th
  • 田辺萌夏, 國澤和生, 齋藤いまり, 小菅愛加, 河合智貴, 窪田悠力, 齋藤邦明, 齋藤邦明, 齋藤邦明, 鍋島俊隆, et al. Decrease of goblet cells in the colon induce spatial cognitive dysfunction followed by social isolation in childhood. 日本生物学的精神医学会(Web). 2022. 44th
ｍore...
Patents (1)：
  • (国内出願) 新規な機能性組成物
Education (3)：
  • 2020 - 2023 Fujita Health University Doctoral Course, Graduate School of Health Science
  • 2018 - 2020 Fujita Health University Master's Course, Graduate School of Health Science
  • 2014 - 2018 Fujita Health University School of Medical Sciences Medical Technology
Professional career (2)：
  • M.S. (Fujita Health University)
  • Ph.D. (Fujita Health University)
Work history (1)：
  • 2022/04 - 現在 Fujita Health University Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS) Assistant professor
Awards (2)：
  • 2021/03 - CINP 2021 Student Encouragement Award
  • 2019/03 - 第 28 回神経行動薬理若手研究者の集い 優秀発表賞
Association Membership(s) (3)：
Society for Neuroscience ,  日本神経精神薬理学会 ,  日本薬理学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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