Rchr
J-GLOBAL ID：202301016168953781   Update date: Jun. 04, 2024

Takami Hirokazu

タカミ ヒロカズ | Takami Hirokazu
Affiliation and department：
Department of Neurosurgery, The University of Tokyo Hospital

About Department of Neurosurgery, The University of Tokyo Hospital


Research field  (4)： Genomics ,  Genomics ,  Neurosurgery ,  Neurosurgery
Research keywords  (3)： 分子生物学 ,  ゲノム解析 ,  脳腫瘍
Research theme for competitive and other funds  (6)：
  • 2022 - 2027 The novel classification system of pediatric brain tumors using machine learning technology
  • 2023 - 2026 Novel fluorescent labeling system for brain tumor surgery and its therapeutic application
  • 2023 - 2026 ゲノム・エピゲノム解析に基づく多層オミクス解析による頭蓋底脊索腫の悪性度分類
  • 2023 - 2026 Elucidation of tumor angiogenesis mechanisms other than HIF pathway and search for novel anti-angiogenic drugs
  • 2022 - 2024 中枢神経悪性胚細胞腫に対する標的治療に向けた、ゲノム構造異常・変異の解明
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Papers (100)：
  • Sina Neyazi, Erika Yamazawa, Karoline Hack, Shota Tanaka, Genta Nagae, Catena Kresbach, Takayoshi Umeda, Alicia Eckhardt, Kenji Tatsuno, Lara Pohl, et al. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation. Acta Neuropathologica. 2024. 147. 1
  • Taijun Hana, Akitake Mukasa, Masashi Nomura, Genta Nagae, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shiro Fukuda, Takayoshi Umeda, Shota Tanaka, et al. Region-specific DNA hydroxymethylation along the malignant progression of IDH-mutant gliomas. Cancer Science. 2024
  • Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, et al. Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression. Frontiers in immunology. 2024. 15. 1328375-1328375
  • Hirokazu Takami, Kaishi Satomi, Kohei Fukuoka, Taishi Nakamura, Shota Tanaka, Akitake Mukasa, Nobuhito Saito, Tomonari Suzuki, Takaaki Yanagisawa, Kazuhiko Sugiyama, et al. Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors. Scientific Reports. 2023. 13. 1
  • Daisuke Sato, Hirokazu Takami, Shunsaku Takayanagi, Masako Ikemura, Reiko Matsuura, Shota Tanaka, Nobuhito Saito. Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications. Brain tumor pathology. 2023. 40. 4. 230-234
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MISC (25)：
  • 高見 浩数, 高柳 俊作, 田中 將太, 齊藤 延人. 【脊椎・脊髄外科の最先端】腫瘍 上衣腫と星細胞腫. Clinical Neuroscience. 2022. 40. 10. 1264-1269
  • 矢島 寛久, 田中 將太, 高見 浩数, 高柳 俊作, 池村 雅子, 齊藤 延人. 脳腫瘍研究のcutting edge-先端画像、実験/分子病理、デジタル病理- 脳腫瘍分子診断時代における網羅的メチル化解析の有用性と課題. Brain Tumor Pathology. 2022. 39. Suppl. 072-072
  • 高柳 俊作, 矢島 寛久, 高見 浩数, 田中 將太, 池村 雅子, 齊藤 延人. 網羅的メチル化解析を施行した成人脳室内pilocytic astrocytomaの一例. Brain Tumor Pathology. 2022. 39. Suppl. 081-081
  • 高見 浩数, 高柳 俊作, 田中 將太, 齊藤 延人. 【Precision Medicine-個別化医療を目指した遺伝子診断と新治療の知見】悪性脳腫瘍 中枢神経胚細胞腫 個別化医療に向けた病態解明の最前線. Neurological Surgery. 2022. 50. 1. 39-50
  • 田中 將太, 高柳 俊作, 高見 浩数, 齊藤 延人. 【Precision Medicine-個別化医療を目指した遺伝子診断と新治療の知見】良性脳腫瘍 頭蓋咽頭腫 分子標的治療の知見. Neurological Surgery. 2022. 50. 1. 171-178
ｍore...
Education (3)：
  • 2012 - 2016 The University of Tokyo
  • 1999 - 2005 The University of Tokyo Faculty of Medicine
  • 1993 - 1999 巣鴨学園
Professional career (2)：
  • PhD (The University of Tokyo)
  • MD (The University of Tokyo)
Work history (13)：
  • 2020/04 - 現在 東京大学医学部附属病院 脳神経外科
  • 2019/08 - 2020/03 東京大学医学部附属病院 脳神経外科
  • 2018/07 - 2019/06 Toronto University Department of Neurosurgery
  • 2016/07 - 2018/06 Mayo Clinic, Rochester, MN Department of Neurologic Surgery
  • 2016/04 - 2016/06 東京大学医学部附属病院 脳神経外科
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Awards (10)：
  • 2023/11 - Society of Neuro-Oncology Top Poster Award Phase II Trial of Pathology-based Three-group Treatment Stratification for Patients With CNS Germ Cell Tumors: A Long-term Follow-up Study
  • 2022/12 - Japan Society for Neuro-Oncology The Top Scoring Abstract Award at The 40th Annual Meeting of Japan Society for Neuro-Oncology Phase II Trial of Pathology-based Three-group Treatment Stratification for Patients With CNS Germ Cell Tumors: A Long-term Follow-up Study
  • 2022/10 - Japanese Congress for Brain Tumor Surgery The President’s Award at The 27th Annual Meeting of the Japanese Congress for Brain Tumor Surgery Clinical and radiographic phenotypes of CNS hemangioblastomas; differences between sporadic and VHL on 184 cases
  • 2021/12 - Japan Society for Neuro-Oncology The Top Scoring Abstract Award at The 39th Annual Meeting of Japan Society for Neuro-Oncology Prognostic Factors of CNS Germ Cell Tumors; Molecular and Histopathological Analyses on 154 Cases from the iGCT Consortium
  • 2021/10 - The Japan Society of Neurosurgery Best Research Paper Award at The 27th Annual Meeting of The Japan Society of Neurosurgery Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts
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Association Membership(s) (13)：
日本分子脳神経外科学会 ,  日本内分泌学会 ,  日本脊髄外科学会 ,  日本遺伝性腫瘍学会 ,  Congress of Neurological Surgeons ,  American Association of Neurological Surgeons ,  American Association of Cancer Research ,  日本脳腫瘍病理学会 ,  日本脳腫瘍学会 ,  日本脳卒中学会 ,  日本脳腫瘍の外科学会 ,  日本間脳下垂体腫瘍学会 ,  日本脳神経外科学会
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