Takahashi Hiroki

タカハシヒロキ | Takahashi Hiroki

Affiliation and department：
Job title： Assistant professor

Research field (4)： Metabolism and endocrinology , Physiology , Clinical pharmacy , Molecular biology

Research theme for competitive and other funds (2)：

2021 - 2023 Elucidation of the mechanism of beiging through identification of phosphatase of histone demethylase JMJD1A
2019 - 2021 脱リン酸化阻害によるJMJD1Aリン酸化維持によりベージュ化が誘導されるかの解明

Papers (5)：

Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, et al. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease. iScience. 2024. 27. 4. 109398-109398
Hiroki Takahashi, Ryo Ito, Yoshihiro Matsumura, Juro Sakai. Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways. BioEssays. 2023. 46. 2
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, et al. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nature Communications. 2022. 13. 1
Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, et al. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nature Communications. 2021. 12. 1
Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, et al. Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch. Nature Communications. 2018. 9. 1

MISC (3)：

伊藤亮, 高橋宙大, 荒井誠, 稲垣毅, 米代武司, 松村欣宏, 酒井寿郎. 交感神経-エピゲノム軸による脂肪細胞の環境適応機構. 実験医学. 2023. 41. 20. 29-37
Mechanisms of Adipocyte Fate Determination Through Epigenetic Changes in Response to Environmental Fluctuations. Bio Industry. 2023. 40. 5. 45-56
Multi-omics in lifestyle-related diseases. 実験医学. 2023. 41. 15

Professional career (1)：

Work history (3)：

2021/04 - 現在 Tohoku University Graduate School of Medicine Assistant professor
2020/04 - 2021/03 The University of Tokyo Research Center for Advanced Science and Technology Postdoctoral Fellow (JSPS PD)
2019/04 - 2020/03 The University of Tokyo Graduate School of Medicine Research Fellow (JSPS DC2)

Awards (8)：

2024/10 - Asia Oceania Association for the Study of Obesity AOCO Rising Star Award
2024/01 - Tohoku University School of Medicine Tohoku Medical Society Scholarship Award A
2023/11 - Japan Society of Cardiovascular Endocrinology and Metabolism Young Investigator Award
2023/11 - Japan Society for the Study of Obesity Young Investigator Award
2023/01 - Japan Society for the Study of Obesity Adiposcience Symposium Young Investigator Award

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