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J-GLOBAL ID:202401008568132200   Update date: Feb. 14, 2025

Koga Hironori

コガ ヒロノリ | Koga Hironori
Affiliation and department:
Job title: Professor
Other affiliations (1):
Research theme for competitive and other funds  (23):
  • 2024 - 2027 Development of aptamers targeting cell adhesion factors characteristically highly expressed in "combined hepatocellular-cholangiocarcinoma" and evaluation of their anti-tumour effects
  • 2024 - 2027 肝細胞癌のWnt5aを介した免疫回避機構の解明と複合免疫治療への応用
  • 2020 - TCF-4 isoform高精度発現解析による肝癌特異的Wntシク ゙ナル異常の探求
  • 2020 - 膵液中エクソソーム解析による膵癌早期診断法開発
  • 2017 - エクソソーム解析による膵癌高精度診断および肝癌特異的血管新生抑制療法の確立
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Papers (122):
  • Toru Nakamura, Atsutaka Masuda, Makoto Kako, Hirayuki Enomoto, Masaki Kaibori, Yasuyuki Fujita, Kyoko Tanizawa, Tetsuya Ioji, Yoshihiro Fujimori, Kei Fukami, et al. Hepatic arterial infusion of autologous CD34+ cells for hepatitis C virus-related decompensated cirrhosis: A multicenter, open-label, exploratory randomized controlled trial. Regenerative therapy. 2024. 27. 455-463
  • Masatoshi Kudo, Kaoru Tsuchiya, Tatsuya Yamashita, Hironori Koga, Yuki Nakagawa, Masafumi Ikeda. Reply to the Letter Regarding "Impact of Bevacizumab Being Skipped due to Adverse Events of Special Interest for Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma Treated with Atezolizumab plus Bevacizumab: An Exploratory Analysis of the Phase III IMbrave150 Study". Liver cancer. 2024. 13. 6. 671-673
  • Hiroyuki Suzuki, Michitaka Fukuda, Tomotake Shirono, Reiichiro Kondo, Toshimitsu Tanaka, Takashi Niizeki, Jun Akiba, Hironori Koga, Takumi Kawaguchi. A Rare Case of Primary Hepatic Undifferentiated Pleomorphic Sarcoma: Exploring Cancer-related Gene Mutations. Internal medicine (Tokyo, Japan). 2024
  • Takahiko Sakaue, Kalpana Deepa Priya Dorayappan, Roman Zingarelli, Wafa Khadraoui, Muralidharan Anbalagan, John Wallbillich, Balazs Bognar, Ross Wanner, Casey Cosgrove, Adrian Suarez, et al. Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin. Oncogene. 2024. 43. 49. 3586-3597
  • Etsuko Moriyama, Shigeo Shimose, Takashi Niizeki, Hideki Iwamoto, Masatoshi Tanaka, Tomotake Shirono, Yu Noda, Masahito Nakano, Ryoko Kuromatsu, Hironori Koga, et al. Efficacy of Atezolizumab Plus Bevacizumab-Transcatheter Arterial Chemoembolization Sequential Therapy for Patients with Intermediate-Stage Hepatocellular Carcinoma. Current oncology (Toronto, Ont.). 2024. 31. 10. 5821-5831
more...
MISC (23):
  • 古賀浩徳. 「New FP療法」さらに前へ 肝がん治療研究に注力. 医事新報(合併号). 2021
  • 古賀浩徳,下瀬茂男,岩本英希,鳥村拓司. アテゾリズマブ・ベバシズマブ併用療法:53例の初期治療成績. アテゾリズマブ・ベバシズマブ併用療法による肝細胞癌治療. 2021. 250-253
  • Mitsuhiko Abe, Takafumi Yoshida, Jun Akiba, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, et al. STAT3 deficiency prevents hepatocarcinogenesis and promotes transdifferentiation of hepatocytes into biliary cells in chronic liver injury of mice. HEPATOLOGY. 2017. 66. 718A-718A
  • Koga H. TCF-4 isoform upregulates CLAUDIN-2, therapy activating NOTCH signaling in human liver cancer cells. Research Report 2015. 2016
  • Koga H, Ikezono Y, Torimura T. Pancreatic DCLK1 marks quiescent but oncogenic progenitors: a possible link to neuroendocrine tumors. Stem Cell Investig. 2016. 3. 37(page 1-2)
more...
Books (6):
  • TCF-4アイソフォームは抗癌剤耐性形質を制御する
    ゲノム情報の臨床応用(第20回浜名湖シンポジウム記録集)、アークメディア 2013
  • 細胞接着破綻が招く上皮間葉移行ー新たに獲得される形質の解析ー
    消化器発癌における炎症・再生・細胞応答の役割、アークメディア(東京) 2007
  • PPARγリガンドによる肝癌細胞のG1期停止機構
    肝臓フォーラム’02記録集 医事出版社(東京) 2003
  • 原発性胆汁性肝硬変におけるUncoupling protein-2の発現
    臨床胆汁酸研究の進歩2002 アークメディア (東京) 2003
  • Involvement of p21WAF1/Cip1 and p27Kip1 in troglitazone-induced cell-cycle arrest in human hepatoma cell lines
    Frontier in Hepatology Springer-Verlag Tokyo 2002
more...
Lectures and oral presentations  (127):
  • Leucine drives LAT1-related EMT in glucose-starved pancreatic cancer cells
    (第83回日本癌学会学術総会 2024)
  • Leucine drives LAT1-related SNAIL upregulation in glucose-starved pancreatic cancer cells
    (第33回日本がん転移学会学術集会・総会 2024)
  • Expression levels of T-cell factor-4 variants in hepato-gastrointestinal cancer cells and tissues
    (AACR Annual Meeting 2024 2024)
  • T-cell factor-4 variants regulate PD-L1 expression in liver cancer cells
    (AACR Annual Meeting 2023 2023)
  • Wntシグナル中枢転写因子TCF-4バリアントの消化器系細胞における発現様式
    (第53回日本臨床分子形態学会総会・学術集会 2021)
more...
Professional career (1):
  • 医学博士
Awards (5):
  • 2018 - JDDW 2018 The Best Presenter Award in International Session
  • 2012/12 - Liver Forum in Kyoto Liver Forum in Kyoto 第15回学術集会 研究奨励賞 Wntシグナル転写因子TCF-4のアイソフォ-ムにおける構造機能相関
  • 2012/12 - 公益財団法人 国際科学振興財団 第20回浜名湖シンポジウム 特別賞(アイデアの独創性) TCF-4アイソフォ-ムは抗癌剤耐性形質を抑制する
  • 2006 - 膵臓病研究財団 膵臓病研究財団研究奨励賞
  • 2001 - 第9回 浜名湖シンポジウム 研究奨励賞
Association Membership(s) (8):
American Association for the Study of Liver Diseases (AASLD) ,  American Association for Cancer Research (AACR) ,  日本臨床分子形態学会(旧 日本臨床電子顕微鏡学会) ,  日本内視鏡学会 ,  日本癌学会 ,  日本肝臓学会 ,  日本消化器病学会 ,  日本内科学会
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