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J-GLOBAL ID：202401013546570347 Update date: Mar. 12, 2025

Coppo Roberto

コッポロベルト | Coppo Roberto

Affiliation and department：
Job title： Postdoctoral Research Fellow
Homepage URL (1)： https://cbrrd.med.kyoto-u.ac.jp/index.html

Research keywords (5)： Mechanisms of non-genetic resistance in cancer , CRISPR gene editing , Bioinformatics , Cancer cell plasticity , Organoid cultures for cancer modeling

Research theme for competitive and other funds (2)：

2023 - 2025 Functional single cell analysis and drug screening in tumor organoids to target slow-growing cells
2022 - 2023 Functional single-cell analysis of the stem cell plasticity associated with drug-tolerant persister cells in colorectal cancer

Papers (16)：

Yoshiaki Matsuura, Kunishige Onuma, Roberto Coppo, Hiroyuki Uematsu, Jumpei Kondo, Aya Miyagawa-Hayashino, Naoko Takeda-Miyata, Kenji Kameyama, Tatsuo Furuya, Satoru Okada, et al. Dynamic change of polarity in spread through air spaces of pulmonary malignancies. The Journal of Pathology. 2025
Yi-Kai Lin, Roberto Coppo, Kunishige Onuma, Hiroko Endo, Jumpei Kondo, Sadahiro Iwabuchi, Shinichi Hashimoto, Yoshiro Itatani, Kazutaka Obama, Masahiro Inoue. Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment. Cancer Science. 2024
Masamune Masuda, Keita Iida, Sadahiro Iwabuchi, Mie Tanaka, Satoshi Kubota, Hiroyuki Uematsu, Kunishige Onuma, Yoji Kukita, Kikuya Kato, Shoji Kamiura, et al. Clonal Origin and Lineage Ambiguity in Mixed Neuroendocrine Carcinoma of the Uterine Cervix. The American Journal of Pathology. 2024. 194. 3. 415-429
Roberto Coppo, Jumpei Kondo, Kunishige Onuma, Masahiro Inoue. Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids. STAR Protocols. 2023. 4. 3. 102395-102395
Hiroyuki Uematsu, Chieko Saito, Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Yukiko Mori, Manabu Muto, Yuichiro Kikawa, Manami Tada, Tomoharu Sugie, et al. De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling. Human Cell. 2023. 36. 6. 2099-2112

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MISC (2)：

Mie Tanaka, Jumpei Kondo, Kensuke Kaneko, Hiroko Endo, Kunishige Onuma, Roberto Coppo, Masamune Masuda, Shoji Kamiura, Kiyoshi Yoshino, Yutaka Ueda, et al. Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix (Mar, 10.1007/s13577-021-00511-5, 2021). HUMAN CELL. 2021. 34. 3. 1028-1030
Coppo Roberto, 近藤純平, 遠藤洋子, 井上正宏. Cancer Tissue-Originated Spheroid(CTOS)法を用いた結腸直腸癌における腫瘍内多様性の解析(Characterization of tumor subclonal heterogeneity in colorectal cancer using cancer tissue-originated spheroid method). 日本癌学会総会記事. 2018. 77回. 1207-1207

Lectures and oral presentations (5)：

A CRISPR dropout screening to identify genetic vulnerabilities in a slow-growing subset of colorectal cancer cells
(83th Annual Meeting of the Japanese Cancer Association, Fukuoka 2024)
Epigenetic regulation of drug-tolerant persister (DTP) cell regrowth after chemotherapy in colorectal cancer organoids
(The 28th Annual Meeting of Japanese Association for Molecular Target Therapy of Cancer, Tokyo 2024)
Unraveling non-genetic heterogeneity, cellular plasticity, and drug resistance in patient-derived colorectal cancer organoids
(65th Advanced Research Seminar, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 2024)
Analysis of intra-tumor heterogeneity in colorectal cancer using the cancer tissue-originated spheroid (CTOS) method
(77th Annual Meeting of the Japanese Cancer Association, Osaka 2018)
Role of ESDN/DCBLD2/CLCP1 protein in melanoma progression
(ABCD Meeting "Mechanisms of signal transduction", Padua, Italy 2014)

Education (1)：

2013 - 2017 University of Turin Dept. Molecular Biotechnology and Health Sciences Doctoral (Ph.D.) in Life and Health Sciences, Biomedical Sciences and Oncology

Professional career (1)：

PhD in Biomedical Sciences and Oncology

Work history (4)：

2024/09 - 現在 Kyoto University, Graduate School of Medicine Dept. of Clinical Bio-Resource Research and Development
2022/09 - 2024/08 Kyoto University, Graduate School of Medicine Dept. of Clinical Bio-Resource Research and Development
2018/04 - 2022/08 Kyoto University, Graduate School of Medicine Dept. of Clinical Bio-Resource Research and Development
2017/04 - 2018/03 Osaka International Cancer Institute

Awards (3)：

2022/07 - JSPS International Fellowships for Research in Japan, Postdoctoral Fellowship (Standard), issued by the Japan Society for the Promotion of Science
2022/04 - EARLY-CAREER SCIENTISTS, GRANTS-IN-AID FOR SCIENTIFIC RESEARCH-KAKENHI (22K15539), issued by KAKEN
2013/01 - Ph.D (Doctor of Philosophy) Scholarship, Ph.D Program in Biomedical Sciences and Oncology, Cycle XXVIII, issued by the University of Turin, Italy

Association Membership(s) (3)：

The Japanese Association for Molecular Target Therapy of Cancer , The Japanese Association for Metastasis Research , The Japanese Cancer Association

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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