Wang Ziyi

• 2024 - 2027 An international collaborative study to examine a novel hypothesis regarding the genetic background and mechanisms of anorexia nervosa caused by excessive exercise
• 2024 - 2027 Understanding the Mechanisms of Tooth Germ Development Using Spatial Single-Cell Epigenome Analysis
• 2024 - 2027 Constructing an in vivo High-Resolution Cell Lineage Analysis System Utilizing Cellular Barcoding Technology
• 2023 - 2027 Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -
• 2024 - 2026 Investigating Mechanotransduction in Embryonic Palatal Development: Bioinformatics Insights and Experimental Validation Using Public Genome-Wide Association Studies and scRNA-seq Data
2022 - 2025 Challenge to elucidate the mechanism of cleft palate development from gene expression analysis linked to spatial information
2022 - 2025 Elucidation of the regulatory mechmisum of odontoblast differentiation by singl cell analysis and its application to therapeutics
2022 - 2025 Filamin A mediated epithelial-mesenchymal transition during embryonic palate development
2021 - 2025 Development of tooth regenerative technology based on the spatiotemporal transcriptome analysis and iPS interference
2022 - 2024 Elucidating the Mechanisms of Palatal Development by Combining Molecular Biology and Information Biology
2021 - 2024 Challenge for analyzing the dysfunctional mechanism of oral barrier repair via dioxin receptor due to smoking
2019 - 2023 Elucidation of mechanosensor function acquisition process of osteocytes using 3D-volumetric image data
2019 - 2023 Epigenetic analysis of regulating bone and mineral metabolism under rare disease in orthognathic lesion
2019 - 2022 Analysis dynamics of HMGB1 as a biosensor molecule and its multiple functions
2018 - 2022 Epigenetic analysis of new bone remodeling mechanism in the dentofacial region.
2019 - 2021 Investigating the mechanism to regulate osteocytes by circadian rhythm that effected by the crosstalk with periodontal ligament cells
2017 - 2021 Regulation of tooth movement-initiated mechanotransduction via osteocytic bone remodeling
2017 - 2019 Functional analysis of RPL5 using induced pluripotent stem cells from the patient with Diamond-Blackfan Anemia

• Ai Orimoto, Ziyi Wang, Mitsuaki Ono, Chiaki Kitamura, Kentaro Ono. Gene expression profiles in human dental pulp stem cells treated short-term with lipopolysaccharides before and after osteoinduction. Journal of Oral Biosciences. 2025. 67. 1. 100603-100603
• Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Shichao Xie, Tomoko Yonezawa, Masahiro Okada, Takuya Matsumoto, Takuo Kuboki, Toshitaka Oohashi. Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model. Regenerative Biomaterials. 2025. 12
• Yao Weng, Ziyi Wang, Heriati Sitosari, Mitsuaki Ono, Hirohiko Okamura, Toshitaka Oohashi. O-GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum. BioFactors. 2024
• Aung Ye Mun, Kentaro Akiyama, Ziyi Wang, Jiewen Zhang, Wakana Kitagawa, Teisaku Kohno, Ryuji Tagashira, Kei Ishibashi, Naoya Matsunaga, Tingling Zou, et al. Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model. JBMR plus. 2024. 8. 8. ziae085
• Anh Tuan Dang, Mitsuaki Ono, Ziyi Wang, Ikue Tosa, Emilio Satoshi Hara, Akihiro Mikai, Wakana Kitagawa, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model. International Journal of Molecular Sciences. 2024. 25. 12. 6648-6648

ｍore...

• Xindi Mu, Mitsuaki Ono, Ha Nguyen, Ziyi Wang, Kun Zhao, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. The Roles of BMP-2 on Modulating Oral Mucosal Keratinization. Journal of Dental Research. 2024. 103. Spec Iss A. 2089
• Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Enhancing Vertical Bone Regeneration With Fibrin-Infused E-RhBMP-2. Journal of Dental Research. 2024. 103. Spec Iss A. 0964
• Ikue Tosa, Benjamin Kheyfets, Hyerin Yoon, Ziyi Wang, Mitsuaki Ono, Mildred Embree. Defining Cartilage Stem/Progenitor Cells During TMJ Development and Homeostasis. Journal of Dental Research. 2024. 103. Spec Iss A. 2726
• Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, et al. Alpha-Pinene As a Novel Therapeutic Agent for T-Cell Tumors. Blood. 2023. 142. Supplement 1. 1441-1441
• Ziyi Wang, Satoru Hayano, Yao Weng, Xindi Mu, Mitsuaki Ono, Toshitaka Oohashi. A mechanosensor protein, Filamin A, mediated embryonic palate fusion through β-catenin/Smad2: A bioinformatics-oriented study. Journal of Bone and Mineral Research. 2023. 38. S2. S406-S407

ｍore...

• Structural Changes in Mitochondria, Cytoskeleton, and Endoplasmic Reticulum During O-GlcNAcylation-Mediated Osteoblast Differentiation: A Bioinformatics and AI Approach
  (APPW2025 [The 130th Annual Meeting of the Japanese Association of Anatomists (JAA)・The 102nd Annual Meeting of the Physiological Society of Japan (PSJ)・The 98th Annual Meeting of the Japanese Pharmacological Society (JPS)] 2025)
• O-GlcNAcylation: A Morphologic Regulator of Osteoblast Differentiation
  (Invited lecture at Shenzhen University General Hospital 2024)
• Filamin A mediates embryonic palatal fusion by linking mechanotransduction with β-Catenin/Smad2
  (7th Research Meeting for International Students 2024)
• Filamin A mediated epithelial-mesenchymal transition during embryonic palate development
  (The 46th Annual Meeting of Japanese Cleft Palate Association 2022)
• The role of circadian rhythm and cell-to-cell communications in osteocytes mechanotransduction
  (Bone-Bio-Engineering Kick-off Symposium 2020)

ｍore...

• A ShinyApp for scRNA-seq analysis
  Ziyi Wang 2024 -
• Flow Cytometric Analysis Frame in R Programming Language
  Ziyi Wang 2022 -
• O-GlcNAcylation drives calcium signaling towards osteoblast differentiation: a bioinformatics-oriented study
  Yao Weng, Ziyi Wang, Hiroshi Kamioka, Hirohiko Okamura 2021 -
• Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes
  Ziyi Wang, Yao Weng, Yoshihito Ishihara, Hiroshi Kamioka 2020 -
• N-(3-oxododecanoyl)-homoserine lactone regulates intracellular calcium of MC3T3 osteoblasts
  Jiajie Guo, Ziyi Wang, Lihong Qiu 2020 -

ｍore...

• 2024/04 - 現在 Okayama University Molecular Biology and Biochemistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Research Assistant Professor
• 2022/04 - 2024/03 Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowships
• 2021/08 - 2022/03 Okayama University Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Technician
• 2021/04 - 2021/07 Okayama University Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Part-time Researcher
• 2019/04 - 2021/03 Japan Society for the Promotion of Science (JSPS) Research Fellowship
2019/05 - 2019/10 Indiana University-Purdue University Indiana Center for Musculoskeletal Health Visiting Faculty
2014/10 - 2015/05 Okayama University Department of Orthodontics Short-term International Student

• 2025/03 - APPW2025 [The 130th Annual Meeting of the Japanese Association of Anatomists (JAA)・The 102nd Annual Meeting of the Physiological Society of Japan (PSJ)・The 98th Annual Meeting of the Japanese Pharmacological Society (JPS)] Young Investigator Award Structural Changes in Mitochondria, Cytoskeleton, and Endoplasmic Reticulum During O-GleNAcylation-Mediated Osteoblast Differentiation: A Bioinformatics and Al Approach
• 2024/03 - Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University The Best Presentation of the 7th Research Meeting for International Students in Okayama University Filamin A mediates embryonic palatal fusion by linking mechanotransduction with β-Catenin/Smad2
• 2018/10 - The 77th Annual Meeting of the Japanese Orthodontic Society Best poster presentation Static force induces change of circadian clock genes in murine osteocytes might change sclerostin distribution
• 2018/10 - The 77th Annual Meeting of the Japanese Orthodontic Society Best oral presentation Bioinformatics analysis shows candidate genes for osteocytes differentially response to different types of mechanical stimuli
• 2018/08 - International Network of Advanced Dental Education & Research Excellent oral presentation of the14th Advanced Dental School Investigate the mechanotransduction of osteocytes: start with bioinformatics
2018/07 - The 36th Annual Meeting of the Japanese Society for Bone and Mineral Research Excellent poster presentation Mechanical signals influence circadian clock genes in murine osteocytes: implications for spatial distribution of sclerostin

The American Society for Bone and Mineral Research (ASBMR) ,  Japanese Cleft Palate Association ,  Japanese Orthodontic Society ,  International Society of Bone Morphometry ,  Japanese Society for Bone and Mineral Research ,  Japanese Society For Bone Morphometry ,  Japanese Association for Oral Biology ,  Chinese Stomatological Association