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J-GLOBAL ID：202401018560995735 Update date: Mar. 25, 2025

Kurihara Takashi

クリハラタカシ | Kurihara Takashi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmacology

Research keywords (3)： Neuropeptides , Neuropathic pain , Pain

Research theme for competitive and other funds (27)：

2024 - 2027 PACAP-PAC1受容体シグナルの乾癬の病態に与える影響と治療応用の可能性
2024 - 2027 慢性疼痛が惹起する不安障害への視床下部室傍核PACAP-モノアミンシグナルの関与の解明
2023 - 2026 光操作法によるニューロリハビリテーションの治療効果と脳・神経可塑性の研究
2023 - 2026 Morphological exploration of cognitive neurocircuits for the gustatory brain-machine interface
2022 - 2026 PACAPによる神経細胞死防御の実体解明と神経再生・新生の基盤研究

2022 - 2025 掻痒疾患における中枢および末梢PACAP受容体シグナル伝達の比較解析

2020 - 2023 Pathophysiological significance of neuron-astrocyte implication of PACAP on stress-induced emotional disorder

2020 - 2023 Innovative research regarding rehabilitation and neuroplasticity using primate cerebral infarction model with hemiplegia

2020 - 2023 Elucidation of Bidirectional Feeding Regulatory Mechanism of PACAP-expressing Neurons in the Ventromedial Hypothalamus and Development of Novel Anti-obesity Drugs

2018 - 2023 What are microglia doing in contact with neurons? -Analysis using a pain model.

2019 - 2022 Dose PACAP-PAC1 receptor signaling contribute to itch transmission ?

2019 - 2022 Does free fatty acid receptor 1 FFAR1 contribute to the development of chronic pain-associated depression ?

2017 - 2020 Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms

2017 - 2020 PACAP/PAC1R signaling in astrocytes involves in fear memory formation

2016 - 2019 Verification of the importance of central FFAR1 system in nociceptive and emotional behaviors in mice

2016 - 2018 Attempt at identifying pathogenic antigens of painful autoimmune neuropathy

2015 - 2018 Investigation of pathogenic mechanisms for central post-stroke pain and its accompanying emotional disorder - evaluation of microglial activation hypothesis

2014 - 2017 Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.

2014 - 2017 Chronic pain treatment strategy targeting PACAP-PAC1-induced astrocyte signaling

2013 - 2016 Strategy for controlling intractable pain by targeting casein kinase 1 signaling system

2013 - 2016 Research on the analgesic mechanism induced by the stimulation of the new free fatty acid receptor GPR40.

2012 - 2015 Development and pharmacological verification of a new mouse model of central post-stroke pain

2010 - 2012 A new pain-related protein kinase signal transduction map: an analysis by phosphor proteomics

2007 - 2009 The roles of neuronal calcium channels on the physiological functions of opioid analgesics

2002 - 2004 電位依存性Ca^<2+>チャネル遺伝子変異マウスを用いた痛覚情報伝達メカニズムの研究

1999 - 2001 神経障害性疼痛により後根神経節において発現変化を受ける遺伝子群の検索

1997 - 1998 アンチセンス法を用いた脊髄痛覚伝達・増強機構に関与するG蛋白質の解析

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Papers (47)：

Ichiro Takasaki, Atsuko Hayata-Takano, Yusuke Shintani, Takashi Kurihara, Hitoshi Hashimoto. Strategy for the development of small-molecule antidepressant targeting PAC1 receptor. Folia Pharmacologica Japonica. 2024. 159. 4. 219-224
Yuki Kambe, Thanh Trung Nguyen, Toshiharu Yasaka, Thu Thi Nguyen, Yoshimune Sameshima, Kohei Hashiguchi, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata. The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus. Molecular neurobiology. 2023. 60. 1. 171-182
Takashi Kurihara. [Possible involvement of FFAR1 signaling in mouse emotional behaviors through the regulation of brain monoamine releases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023. 158. 6. 454-459
Yuki Kambe, Masafumi Youkai, Kohei Hashiguchi, Yoshimune Sameshima, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara. Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice. Biomolecules. 2022. 12. 12
Yusuke Shintani, Yui Yamano, Manato Kuta, Rei Takeshita, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, et al. Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice. Biochemical and biophysical research communications. 2022. 631. 146-151

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MISC (46)：

栗原崇. 【神経・精神疾患の病態における多価不飽和脂肪酸の関与】FFAR1シグナルはモノアミン遊離を調節することで情動行動に影響を与える. 日本薬理学雑誌. 2023. 158. 6. 454-459
神戸悠輝, 栗原崇, 宮田篤郎. 視床下部腹内側核PACAPによる神経ペプチドネットワークを介した摂食行動の調節. 日本内分泌学会雑誌. 2022. 98. 1. 308-308
吉野紀美香, 飯笹栄一, 原博満, 栗原崇, 宮田篤郎. 脊髄損傷霊長類モデルを用いた自律神経回路再編による免疫機構破綻メカニズムの解明. 日本自律神経学会総会プログラム・抄録集. 2021. 74回. 124-124
橋口浩平, 神戸悠輝, 杉村光隆, 栗原崇, 宮田篤郎. 次世代の若手研究者が切り開く薬学研究の発展と医療への貢献 PACAPは視床下部室傍核において末梢神経障害性疼痛に伴う不安様行動発現に寄与する. 日本薬学会年会要旨集. 2021. 141年会. GS04-1
栗原崇, 宮田篤郎, 高崎一朗. Back to Basics科学的基盤に立脚した次世代の薬物治療を創る PACAP受容体特異的有機低分子拮抗薬のイン・シリコ創薬難治性疼痛・そう痒治療に向けて. 臨床薬理. 2020. 51. Suppl. S240-S240

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Patents (5)：

Nr4a1拮抗薬を用いた鎮痛薬
PAC1受容体拮抗薬を用いた抗うつ・抗不安薬
PAC1受容体拮抗薬を用いた鎮痒薬
PAC1受容体拮抗薬を用いた鎮痛薬
疼痛に関する化合物及び医薬組成物

Books (4)：

ベッドサイドの薬理学
丸善出版 2018 ISBN:9784621302743
痛み診療キーポイント (痛みのScience & Practice 第6巻)
文光堂 2014 ISBN:9784830628375
感覚器官と脳内情報処理
共立出版 2002 ISBN:4320055632
イオンチャネルの分子生物学
羊土社 1998 ISBN:4897063205

Education (3)：

1992 - 1996 Tokyo Medical and Dental University
1990 - 1992 Tokyo University of Science
1986 - 1990 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

Work history (7)：

2018/04 - 現在 Shigakukan University Faculty of Humanities Department of Clinical Psychology
2014/04 - 現在 Kagoshima Women's Junior College Department of Domestic Science
2010/05 - 現在 Kagoshima University Department of Pharmacology, Graduate School of Medical and Dental Sciences Associate Professor
2007/04 - 2010/04 Tokyo Medical and Dental University
2004/04 - 2007/03 Tokyo Medical and Dental University Department of Pharmacology and Neurobiology, Graduate Shcool of Medicine Assistant Professor

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Association Membership(s) (4)：

日本疼痛学会 , International Association for the Study of Pain , 日本薬理学会 , 日本神経科学会

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