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J-GLOBAL ID：200901015795091071 Update date: Mar. 15, 2025

Murohara Toyoaki

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Affiliation and department：
Job title： Professor

Research field (1)： Cardiology

Research keywords (11)：代謝異常と循環器疾患 , Renin-Angiotensin System , Hyperlipidemia , Hypertension , Cardiovascular Medicine , Bone marrow stem cell , Endothelial cell , Regenerative Medicine , Therapeutic Angiogenesis , Vascular Regenerarion , Vascular Biology

Research theme for competitive and other funds (70)：

2022 - 2025 脂肪組織由来間葉系前駆細胞を用いたリンパ浮腫に対するリンパ管新生療法の開発研究
2022 - 2025 肺細動脈内皮細胞で特徴的変化を示す分子に着目した肺高血圧症への新規治療戦略の開発
2021 - 2024 新規抗炎症性アディポカインによる心臓病、腎臓病制御機構の解明
2021 - 2024 劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発
2021 - 2024 ホルモン連関とクローン性造血から探る糖尿病性心筋症の原因解析

2020 - 2024 Role of myokines in preventing the development of age-related diseases

2020 - 2023 脂肪組織由来間葉系前駆細胞を用いた血管新生療法の分子基盤探索

2020 - 2023 心臓の硬化を制御するG蛋白質共役受容体の機能解明と心不全治療薬シーズの探索

2019 - 2022 Glucagon-dependent autonomic regulatory system and its role in cardiovascular disease

2018 - 2021 Role of glucagon in diabetic cardiomyopathy and angiogenesis

2017 - 2020 The potential of omentin as therapeutic agents for cardiovascular disease.

2017 - 2020 Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts

2017 - 2020 Role of the novel myokine myonectin in regulation of ischemic heart disease

2017 - 2020 Role of VEGF165b, an inhibitory vascular endothelial growth factor splice variant, in pulmonary hypertension

2016 - 2020 Pathophysiological significance of the Klotho-FGF system in myocardial diseases

2017 - 2019 脂肪組織由来間葉系前駆細胞を用いた誘導心筋細胞による心筋再生療法の開発

2016 - 2019 Regulation of pathological vascular remodeling by a novel adipocytokines

2016 - 2019 Role of aging regulatory protein WRN in cardiac fibrosis

2015 - 2018 Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

2014 - 2017 The role of omentin in the vascualr disease

2014 - 2017 Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drug

2014 - 2017 Role of the novel adipocytokine in regulation of cardiovascular disease

2014 - 2017 自己脂肪組織由来幹細胞を用いた心血管系再生医療の総合的開発研究

2015 - 2016 Role of C1q/TNF-related protein 1 in ischemic heart disease

2015 - 2016 細胞移植による劇症型心筋炎に対する心筋保護療法の試み

2013 - 2016 Pathophysiological significance of cathepsin K in dilated cardiomyopathy

2013 - 2016 Regulation of Notch signal pathway in adipogenesis

2013 - 2016 Cardiac myocyte-derived follistatin like 1 protects the kidney after subtotal nephrectomy

2013 - 2016 New therapeutic approach for targeting endothelium-derived hyper polarizing factor in the intimal hyperplasia of vein and artery grafts.

2012 - 2016 Therapeutic approach for diastolic heart failure through regenerative medicine

2012 - 2016 Impact of myocardial gene expression and exercise capacity in cardiomyopathy

2012 - 2014 The novel fat-derived hormone as a therapeutic target for acute coronary syndrome

2011 - 2014 Establishment of therapeutic lymphangiogenesis for lymphedema

2011 - 2014 Role of the myocyte-derived secreted factor in ischemic heart disease

2008 - 2013 Development of angiogenic cell therapy using iPS cell-derived vascular progenitor cells

2011 - 2013 Comprehensive And Therapeutic Strategy for Heart Failure Via Dipepidylpepidase-4 (DPP-4) Axis.

2010 - 2012 Individualized indication for Cardiac resynchronization therapy

2008 - 2011 血管再生障害からみた糖尿病性心筋症の基礎解析と新規治療法の開発

2009 - 2011 Therapeutic angiogenesis using adipose-derived regenerative cells

2009 - 2011 Identification and function analysis of micro RNAs in progression of heart failure

2009 - 2011 Adipocytokine is the new target of the strategy for the prevention of intimal hyperplasia

2006 - 2008 前駆細胞移植による血管再生療法の分子基盤探索と新規臨床応用に向けた展開研究

2007 - 2008 Development of angiogenetic and regenerative therapy with regulation of Notch signaling

2007 - 2008 Analysis for the association between mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarction

2007 - 2008 To detect non-coding RNA related to heart failure

2006 - 2008 A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis

2006 - 2008 New Gene Therapy-Controlled Release of siRNA as to Midkine Inhibits the Intimal Hyperplasia in Vein Grafts

2006 - 2007 Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation-promotion

2007 - 磁場と磁気ナノ粒子を用いた細胞シート工学とその再生医療への応用開発研究

2003 - 2005 バイオペースメーカー細胞の樹立と徐脈性不整脈の細胞治療

2000 - 2005 内皮前駆細胞移植を応用した虚血心筋の血管新生療法の開発

2004 - 2005 Therapeutic angiogenesis using noble human VEGF-E chimeric genes and autologous bone marrow mononuclear cells

2004 - 2005 Basic Research for Biological Pacemaker

2003 - 2005 Research on Establishment of Supporting System for In-Home Cardiovascular Medicine

2000 - 2005 Molecular Mechanisms of Heat Failure and Its Novel Therapeutic Strategies

2003 - 2004 Relationshio pregenitor cells derived from bone marrow and graft intimal hyperplasia

2003 - 2004 造血器腫瘍の病態に関わる癌遺伝子、癌抑制遺伝子変異の解析

2002 - 2004 NEW TREATMENT FOR PULMONAY HYPERTENSION

2000 - 2004 血管新生と血管保護療法の開発に関する研究

2002 - 2003 細胞移植による血管新生療法の改良型開発のための基礎研究

2000 - 2002 末梢血幹細胞移植を応用した新しい虚血部血管新生療法の開発

2001 - 2002 Study of inhibitory effects of HMG Co A reductase inhibitor on in-vivo thrombus formation

2000 - 2001 コロニー刺激因子を用いた新しい虚血部血管新生療法の開発-内皮前駆細胞動員療法-

1999 - 2001 ヒト臍帯血からの内皮前駆細胞単離および分化誘導と血管新生療法への応用

2000 - 2001 Vascular remodeling in Kawasaki disease

2000 - 2001 Role of matrix metalloproteinase during arterial thrombus formation

1999 - 2000 自己骨髄単核細胞移植による心筋梗塞後血管新生療法の実験的試み

1998 - 2000 Pathophysiology in platelet-mediated thrombus model

1998 - 1999 高脂血症における組織虚血後の血管新生に関する研究

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Papers (1,140)：

Shin Nagai, Hiroaki Hiraiwa, Ryota Ito, Yuichiro Koyama, Kiyota Kondo, Shingo Kazama, Toru Kondo, Ryota Morimoto, Takahiro Okumura, Hideki Ito, et al. Usefulness of bicarbonate-based Impella purge solution in a patient with heparin-induced thrombocytopenia: the first case report of long-term management in Japan. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 2025. 28. 1. 83-89
Yiyang Che, Yuuki Shimizu, Toyoaki Murohara. Therapeutic Potential of Adipose-Derived Regenerative Cells for Ischemic Diseases. Cells. 2025. 14. 5. 343-343
Kunihiko Takahara, Noriyuki Ouchi, Tomonobu Takikawa, Yuta Ozaki, Lixin Fang, Hiroshi Kawanishi, Minako Tatsumi, Yoshimitsu Yura, Katsuhiro Kato, Mikito Takefuji, et al. Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice. Physiological reports. 2025. 13. 3. e70135
Reina Ozaki, Sadako Motoyama, Yukio Ozaki, Masayoshi Sarai, Hideki Kawai, Tevfik F. Ismail, Wakaya Fujiwara, Keiichi Miyajima, Yasuomi Nagahara, Noriya Uchida, et al. Impact of CT-angiography derived plaque characteristics on cardiac events in patients with a negative invasive fractional flow reserve. International Journal of Cardiology. 2025. 421. 132895-132895
Hiroaki Hiraiwa, Shin Nagai, Ryota Ito, Kiyota Kondo, Shingo Kazama, Toru Kondo, Shiro Adachi, Kenji Furusawa, Akihito Tanaka, Ryota Morimoto, et al. Ability of dynamic chest radiography to identify left ventricular systolic dysfunction in heart failure. The international journal of cardiovascular imaging. 2025

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MISC (1,161)：

中野嘉久, 足立史郎, 廣瀬未来, 安達健, 西山軼群, 安田健一郎, 吉田雅博, 岩野信吾, 八谷寛, 近藤隆久, et al. Refined CTプロトコールによる急性肺塞栓症1年後の残存血栓の検出. 日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集. 2022. 7回・28回. 126-126
西山軼群, 足立史郎, 安田健一郎, 吉田雅博, 中野嘉久, 近藤隆久, 室原豊明. 肺動脈血栓内膜摘除術数年後に収縮性心内膜炎を発症した一例. 日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集. 2022. 7回・28回. 139-139
小林聖典, 六鹿雅登, 六鹿雅登, 奥村貴裕, 奥村貴裕, 平岩宏章, 平岩宏章, 近藤徹, 近藤徹, 室原豊明, et al. 高齢植込み型補助人工心臓装着患者の運動機能に関する検討. 人工臓器(日本人工臓器学会). 2020. 49. 2
小林聖典, 奥村貴裕, 奥村貴裕, 平岩宏章, 平岩宏章, 近藤徹, 近藤徹, 六鹿雅登, 六鹿雅登, 藤本和朗, et al. LVAD装着術後患者の退院時下肢筋力は再入院と関連する. 日本心不全学会学術集会プログラム・抄録集. 2020. 24th (CD-ROM)
大石英生, 奥村貴裕, 清水美帆, 竹内晴美, 荒尾嘉人, 加藤宏雄, 桑山輔, 羽賀智明, 山口尚悟, 横井剛, et al. Exercise and Nutritional Intervention in the Acute Phase of Cardiac/Intensive Care in Patients with Advanced Heart Failure. 日本循環器学会学術集会(Web). 2019. 83rd

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Patents (1)：

Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue.

Professional career (2)：

医学博士 (熊本大学)
Medical Doctor (Kumamoto University)

Work history (12)：

2004/10/01 - 現在 Nagoya University Program in Integrated Molecular Medicine Professor
2002/06/01 - Department of Cardiology, Nagoya University Graduate School of Medicine
1997/07/01 - 2002/05/31 Department of Internal Medicine III, Kurume University School of Medicine
1996/03/01 - 1997/06/30 Department of Cardiology, St. Elizabeth's Medical Center, Tufts University School of Medicine
1993/09/01 - 1996/02/28 Department of Physiology, Jefferson Medical School of Thomas Jefferson University

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Association Membership(s) (8)：

European Society of Cardiology , 日本血管生物医学会 , 日本動脈硬化学会 , 日本心不全学会 , 日本高血圧学会 , Japanese Society of Internal Medicine , American Heart Association , Japanese Circulation Society

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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