Research field (2)：
Pharmaceuticals - chemistry and drug development
, Structural biochemistry
Research keywords (9)：
核内受容体
, NMR-構造解析
, X-線結晶構造解析
, 構造生物学
, 創薬化学
, Drug design
, Fatty Acid
, Nuclear Receptor
, Structural Study
Research theme for competitive and other funds (2)：
2018 - 2021 A study of covalent modifier evaluation method using HDX
2008 - 2010 Role of ligands for allosteric network of nuclear receptors
Papers (79)：
Tatsuhiro Kyoya, Hiroaki Ishida, Toshiaki Saitoh, Toshimasa Itoh. Preparation of ethynylsulfonamides and study of their reactivity with nucleophilic amino acids. Organic & Biomolecular Chemistry. 2025
Tetsuya Yano, Takahiro Yamada, Hiroaki Isida, Nami Ohashi, Toshimasa Itoh. 2-cyanopyridine derivatives enable N-terminal cysteine bioconjugation and peptide bond cleavage of glutathione under aqueous and mild conditions. RSC Advances. 2024
Hiroyuki Kojima, Ryota Yanagi, Eri Higuchi, Mami Yoshizawa, Tomoyuki Shimodaira, Misaki Kumagai, Tatsuhiro Kyoya, Miyu Sekine, Daichi Egawa, Nami Ohashi, et al. Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry. Journal of Medicinal Chemistry. 2023. 66. 7. 4827-4839
Miyu Sekine, Hiroaki Ishida, Toshimasa Itoh. Synthesis of Triazolo[c]coumarins and Differences in the Fluorescence Properties of Their Isomers. Asian Journal of Organic Chemistry. 2023. 12. 5
藤間祥子, 藤間祥子, 中村雄太郎, 川本晃大, 寺谷俊昭, 清水光, 廣瀬未果, 端山浩輝, 小島瑠璃, 吉村奏美, et al. The nuclear transport mechanism of PPARg revealed by the Cryo-EM structure. 日本薬学会年会要旨集(Web). 2024. 144th
大橋南美, 永田志織, 松本侑奈, 直島史織, 吉澤麻美, 江川大地, 伊藤俊将, 山本恵子. The packing structure and crystallization of vitamin D receptor/co-activator peptide complex. 日本薬学会年会要旨集(Web). 2022. 142nd
藤間祥子, 中村雄太郎, 寺谷俊昭, 川本晃大, 清水光, 廣瀬未果, 端山浩輝, 大畑慎也, 林有吾, 山崎洋一, et al. Structural insight into the nuclear transport mechanism of PPARg. 日本薬学会年会要旨集(Web). 2022. 142nd
