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J-GLOBAL ID：200901021293060997 Update date: Oct. 17, 2024

Kugoh Hiroyuki

クゴウヒロユキ | Kugoh Hiroyuki

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Research field (2)： Cell biology , Tumor biology

Research keywords (2)：細胞工学, がん抑制遺伝子, 染色体工学, 細胞老化, エピジェネティクス,発がん , Cytogenetics & Cell Genetics

Research theme for competitive and other funds (39)：

2023 - 2026 染色体工学技術と次世代シーケンス解析の融合による膵がんの新規がん抑制経路の同定
2022 - 2025 染色体工学技術を利用した細胞老化誘導遺伝子(がん抑制遺伝子)の同定
2021 - 2024 染色体工学技術を利用した膀胱がんの発がんと進展過程における分子メカニズムの解明
2019 - 2022 Study to investigate the mechanism of oral cancer development by using genome writing and chromosome engineering technology.
2015 - 2018 A study examining the mechanism underlying the determination of the normal body temperature

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Papers (91)：

Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh. Correction to: Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2023. 31. 3. 20-20
Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, et al. Characterization of human anti-EpCAM antibodies for developing an antibody-drug conjugate. Scientific Reports. 2023. 13. 1
Ryutaro Shimizu, Takahito Ohira, Takuki Yagyu, Tetsuya Yumioka, Noriya Yamaguchi, Hideto Iwamoto, Shuichi Morizane, Katsuya Hikita, Masashi Honda, Atsushi Takenaka, et al. Activation of PPARγ in bladder cancer via introduction of the long arm of human chromosome 9. Oncology Letters. 2022. 23. 3
Mizuho Ishikawa, Mitsuhiko Osaki, Narumi Uno, Takahito Ohira, Hiroyuki Kugoh, Futoshi Okada. MTA1, a metastasis-associated protein, in endothelial cells is an essential molecule for angiogenesis. Molecular medicine reports. 2022. 25. 1
Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, et al. Establishment of an Antibody Specific for AMIGO2 Improves Immunohistochemical Evaluation of Liver Metastases and Clinical Outcomes in Patients with Colorectal Cancer. 2021

MISC (110)：

坂野悠, 坂野悠, 大平崇人, 大平崇人, 柳生拓輝, 藤原義之, 久郷裕之, 久郷裕之. The regulatory mechanism of mTERT suppression effects in pancreatic cancer cells using human artificial chromosomes. 日本癌学会学術総会抄録集(Web). 2023. 82nd
大平崇人, 大平崇人, 久郷裕之, 久郷裕之. Mapping of hTERT suppressor genes via human artificial chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
黄晴華, 大平崇人, 大平崇人, 久郷裕之, 久郷裕之. SIN3A and E2F1 promotes hTERT mRNA transcription in human oral squamous cell carcinoma cells. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
坂野悠, 坂野悠, 大平崇人, 大平崇人, 藤原義之, 久郷裕之, 久郷裕之. Human artificial chromosome carrying 3p21.3-p22.2 region suppressesm Tert mRNA transcription in murine pancreatic cancer cells. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
清水龍太郎, 大平崇人, 大平崇人, 弓岡哲也, 岩本秀人, 森實修一, 本田正史, 久郷裕之, 久郷裕之, 武中篤. Elucidation of a Novel Carcinogenic Regulatory Mechanism in Bladder Cancer. 日本がん転移学会学術集会・総会プログラム抄録集. 2021. 30th

Books (2)：

Transfer of a normal human chromosome 11 suppresses tumorigenicity of some but not all tumor cell lines.
Genetic Mechanisms in Carcinogenesis and Tumor Progression, Wiley-Liss, Inc. 1991
Multiple chromosomes carrying tumor suppressor activity, via microcell-mediated chromosome transfer, for various tumor cell line.
Genetic Basis for Carcinogenesis: Tumor Suppressor Genes and Oncogenes, Jpn. Sci. Soc. Press., Tokyo/Taylor & Francis, Ltd., London, (eds. Kunudson, A.G.Jr., et al.) 1990

Lectures and oral presentations (108)：

Characterization of human anti-EpCAM antibodies for developing an antibody-drug conjugate
(第1回日本抗体学会 2022)
染色体工学を用いたFXSモデル動物の作製-人工染色体へのFXD領域の搭載-
(第45回日本分子生物学会年会 2022)
染色体工学を適用した脆弱X症候群責任脆弱部位のクローニング
(第45回日本分子生物学会年会 2022)
鳥取から生まれる染色体工学技術の最前線
(とっとりバイオフロンティアX MEDISO 2022)
口腔扁平上皮がんにおいて、3p21.3領域を搭載した人工染色体はhTERT発現を抑制する
(第81回日本癌学会学術総会 2022)

Education (2)：

Professional career (1)：

Work history (8)：

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Awards (6)：

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Association Membership(s) (5)：

アメリカ癌学会 , 日本分子生物学会 , 染色体学会 , 日本人類遺伝学会 , 日本癌学会

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