Tamura Masato

タムラマサト | Tamura Masato

Affiliation and department：
Job title： Professor

Research field (2)： Oral medicine , Medical biochemistry

Research keywords (8)：骨芽細胞 , 骨形成 , 遺伝子発現 , 転写因子 , Wntシグナル , tRNaseZ , Wnt , Cell Biology

Research theme for competitive and other funds (34)：

2020 - 2024 骨芽細胞が産生する新規SLRPを介した脂肪細胞分化・脂質代謝の制御機構の解明
2020 - 2024 ”舌の老い”とは?エピジェネティクスの視点からオーラルフレイルに迫る
2017 - 2020 骨細胞が産生・分泌する分子による脂肪組織・脂質代謝制御の分子機構
2014 - 2017 骨と脂肪組織の臓器間クロストークに関わる分子とその調節機構の解明
2012 - 2015 Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA based on TRUE gene silencing.

2010 - 2014 Molecular mechanism of networking system between bone and hematopoietic cells via Wnt signaling pathway

2011 - 2013 Regulation of osteoblastic differentiation by the ubiquitin-proteasome pathway and novel induction of bone formation

2009 - 2011 Study of cementogenesis and Wnt signaling

2008 - 2010 TRUEジーンサイレンシング法によるマイクロRNA制御による骨形成誘導法の開発

2007 - 2009 Molecular mechanisms on differentiation or function of osteoblasts and osteoclasts by the Wnt/LRP signaling pathway

2006 - 2007 sgRNAを用いた新規骨形成誘導法の開発

2006 - 2007 Elucidation of molecular mechanism underlying smooth muscle-like differentiation of fibroblastic cells derived from periodontal ligament.

2005 - 2006 The promotional effect for bone formation by ultrasound mediated gene transfer (sonoporation) on Wnt-related gene at sites of distraction osteogenesis

2004 - 2006 STUDY OF BONE FORMATION SIGNALING IN WNT-LRP-DKK AND PROTEOSOME SYSTEM

2004 - 2004 抗腫瘍性アポトーシス誘導型RNAヘプタマーによる個体レベルでのがん治療法の開発

2003 - 2004 特異的タンパク質ノックダウン法を用いた細胞外基質と骨形成シグナルの相互作用の解析

2003 - 2003 細胞間情報伝達システムの解明による歯周組織再生

2001 - 2002 Physiological functions and mechanisms on post-transcriptional regulation of RNA-binding proteins in osteoblastic differentiation.

2000 - 2002 A basic research for use of hepatocyte growth factor (HGF) for diagnosis and treatment of periodontal disease.

2000 - 2002 Expression of enamel matrix protein in vitro

1999 - 2000 BINDING PROTEINS FOR UTR OF OSTEOCALCIN GENE AND THESE FUNCTIONS IN OSTEOBLASTC DIFFERENTIATION

1997 - 2000 Analyses of Molecular Mechanisms Involved in Pathogenesis of 0steoporosis

1997 - 1997 骨芽細胞における特異的な遺伝子発現に関与する転写調節因子の構造と機能

1996 - 1997 Molecular analysis on osteoporosis using transgenic mice

1996 - 1997 Receptor and signal transduction of bone morphogenetic protein (BM)

1995 - 1997 Molecular analysis of epithelial mesenchymal interaction during tooth formatio

1995 - 1997 Development of drugs for osteoporosis using transgenic mice

1996 - 1996 オステオカルシン遺伝子の骨芽細胞特異的発現に関与する転写調節因子の構造と機能

1993 - 1996 Research on the Molecular Mechanism of Osteoporosis

1995 - 1995 オステオカルシン遺伝子の骨芽細胞特異的発現に関与するHLH型転写因子の構造と機能

1994 - 1994 オステオカルシン遺伝子プロモーターのE-boxに結合するHLH型転写因子の研究

1993 - 1994 プライオトロフィン(PTN)による骨芽細胞の分化ならびに機能調節の解析

Structure and Function of tRNaseZ and regulation of gene expression using these enzyme

Molecular Mechanisms for bone formation and resorption

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Papers (90)：

Kiyomi Tsuji-Tamura, Mari Sato, Masato Tamura. Pharmacological control of angiogenesis by regulating phosphorylation of myosin light chain 2. Cellular signalling. 2024. 111223-111223
Kanako Nagamoto, Ko Nakanishi, Tsukasa Akasaka, Shigeaki Abe, Kumiko Yoshihara, Mariko Nakamura, Hiroshi Hayashi, Shinji Takemoto, Masato Tamura, Yoshimasa Kitagawa, et al. Investigation of a new implant surface modification using phosphorylated pullulan. Frontiers in bioengineering and biotechnology. 2024. 12. 1378039-1378039
Hidekazu Yamamoto, Kazuhiro Matsushita, Hirokazu Takada, Masahiko Suito, Masato Tamura. Application of a Titanium Screw for the Hemorrhage from the Bone Channel during the Lateral Window Technique: A Technical Note. Case Reports in Dentistry. 2023. 2023. 1-3
Kiyomi Tsuji-Tamura, Masato Tamura. Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation. FEBS letters. 2022. 596. 13. 1686-1699
Hidekazu Yamamoto, Kazuhiro Matsushita, Kazufumi Yamaguchi, Mutsuki Yamagishi, Masato Tamura. Augmentation of the width and thickness of keratinised gingiva using a collagen biomaterial in apically positioned flap surgery: a technical note. The British journal of oral & maxillofacial surgery. 2022. 60. 4. 516-518

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MISC (91)：

Tatsuya Shimizu, Fujita Naomasa, Sato Mari, Tsuji-Tamura Kiyomi, Kitagawa Yoshimasa, Fujisawa Toshiaki, Tamura Masato. Osteocytes as main responders to Low Intensity Pulsed Ultrasound for the treatment of fracture healing. JOURNAL OF BONE AND MINERAL RESEARCH. 2020. 35. 193-193
田村潔美, 田村正人, 小川峰太郎. 血管内皮細胞におけるmTORC1/mTORC2阻害剤の効果. Journal of Oral Biosciences Supplement. 2018. 2018. 160-160
田村潔美, 田村正人, 小川峰太郎. 血管内皮細胞の伸張機能に着目した、血管形成の新たな指標の探索. Journal of Oral Biosciences Supplement. 2017. 2017. 206-206
田村潔美, 田村正人, 小川峰太郎. PI3K-AktとmTORC1シグナルは血管内皮細胞の伸長機能を制御する. Journal of Oral Biosciences Supplement. 2016. 2016. 228-228
向阪幸彦, 金谷聡介, 須藤瑞樹, 田村正人, 島内英俊, 根本英二. ナノハイドロキシアパタイトによる歯小嚢細胞のWnt/β-cateninシグナル誘導. 日本歯周病学会会誌(Web). 2015. 57. 126

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Books (5)：

口腔生化学第6版
医歯薬出版 2018
Interface Oral Health Science 2007
Springer 2008 ISBN:9784431766896
Possible etiological role in Kawasaki disease of viridans group streptococci producting erythrogenitic toxin : Report on the project study of the research committee on Kawasaki disease, Japan Heart Foundation. (jointly worked)
Proceeding of the Fourth International Symposium on Kawasaki Disease, American Heart Association. Futura Publising Co. , Inc. 1993
Human Amelogenin Gene. Tooth Enamel V (共著)
Florence Publishers 1989
Human Amelogenin Gene. (jointly worked)
Tooth Enamel V Florence Publishers, 1989

Professional career (1)：

Ph.D. (Tokyo Medical and Dental University)

Work history (5)：

2001/09 - 現在 Hokkaido University Graduate School of Dental Medicine
1999/04 - 2001/09 Kagoshima University Dental School
1997/09 - 1999/03 Kagoshima University Dental School
1992/04 - 1997/08 Tokyo Medical and Dental University Medical Research Institute
1991/05 - 1992/03 Kagoshima University Dental School

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