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J-GLOBAL ID：200901027018069567 Update date: Mar. 05, 2025

SEKINE Shun-ichi

関根俊一 | SEKINE Shun-ichi

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Affiliation and department：
Job title： Team Leader

Research field (1)： Structural biochemistry

Research keywords (15)： CryoEM , X線結晶構造解析 , クロマチン転写 , Viral replication , RNAポリメラーゼ , RNA polymerase II , アミノアシルtRNA合成酵素 , セレノシステイン , Cryo-EM , X-ray crystallography , Transcription , RNA polymerase , Translation , tRNA , Selenocysteine

Research theme for competitive and other funds (9)：

2020 - 2025 植物の不均一環境変動へのレジリエンスを支える転写開始点制御機構
2020 - 2025 Structural basis of higher-order complexes connecting transcription and its related functions
2020 - 2024 RNAポリメラーゼを中心に形成される中核的複合体の構造基盤
2015 - 2020 Structural basis of RNA polymerase regulation by transcription factors
2011 - 2015 Structural and functional studies of multiple complexes of RNA polymerase

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Papers (108)：

Masahiro Naganuma, Mari Aoki, Mikako Shirouzu, Mie Goto, Tamami Uejima, Sayako Kohno, Haruhiko Ehara, Shun-ichi Sekine, Tomoya Kujirai, Hitoshi Kurumizaka, et al. Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. Science Advances. 2025
Tomoya Kujirai, Haruhiko Ehara, Tomoko Ito, Masami Henmi, Shun-ichi Sekine, Hitoshi Kurumizaka. Structural basis of transcription-coupled H3K36 trimethylation by Set2 and RNAPII elongation complex in the nucleosome. 2024
Masahiro Shimizu, Hiroki Tanaka, Masahiro Nishimura, Nobuhiro Sato, Kayo Nozawa, Haruhiko Ehara, Shun-ichi Sekine, Ken Morishima, Rintaro Inoue, Yoshimasa Takizawa, et al. Asymmetric fluctuation of overlapping dinucleosome studied by cryoelectron microscopy and small-angle X-ray scattering. PNAS Nexus. 2024
Tatsuo Yanagisawa, Yuko Murayama, Haruhiko Ehara, Mie Goto, Mari Aoki, Shun-ichi Sekine. Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex. Nature Communications. 2024
Tomoaki Kimura, Seiya Hirai, Tomoya Kujirai, Risa Fujita, Mitsuo Ogasawara, Haruhiko Ehara, Shun-Ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka. Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K. Genes to cells : devoted to molecular & cellular mechanisms. 2024

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MISC (5)：

苫米地由里, 井上敏, 細谷孝充, 関根俊一, 白水美香子. 発光反応の遅い半合成cf3-イクオリンの結晶構造解析. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
伊藤弓弦, 伊藤弓弦, 関根俊一, 関根俊一, 松本英子, 赤坂領吾, 竹本千重, 白水美香子, 横山茂之, 横山茂之. セレノリン酸合成酵素の構造解析. 生化学. 2008
上西達也, 川添将仁, 竹本千重, 齋藤由美, 関根俊一, 白水美香子, WILSON Daniel N., FUCINI Paola, 横山茂之, 横山茂之. 高度好熱菌リボソーム複合体の結晶構造解析. PFシンポジウム要旨集. 2007. 24th
別所義隆, 柴田理恵, 村山和隆, 村山和隆, 関根俊一, 関根俊一, 東島今日子, 竹本千重, 白水美香子, 倉光成紀, et al. 好熱菌tmRNA-tRNAドメインの結晶構造解析. RNAミーティング. 2005. 7th
川添将仁, 竹本(堀)千重, 上西達也, 関根俊一, 白水美香子, 横山茂之. 高度好熱菌Eraの構造と機能の解析. 日本分子生物学会年会プログラム・講演要旨集. 2004. 27th

Education (3)：

The University of Tokyo Graduate School of Science
Tohoku University
University of Tokyo

Professional career (1)：

Ph D.

Work history (8)：

2013 - 現在理化学研究所チームリーダー
2012 - 理化学研究所上級研究員
2010 - :東京大学大学院理学系研究科特任准教授
2004 - :東京大学大学院理学系研究科講師
2001 - :理化学研究所研究員

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Association Membership(s) (2)：

日本分子生物学会 , 日本蛋白質科学会

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