Rchr
J-GLOBAL ID：200901027859739494
Update date: Apr. 04, 2025
Uchida Takafumi
ウチダ タカフミ | Uchida Takafumi
Affiliation and department：
Job title：
Emeritus Professor
Research field (5)：
Molecular biochemistry
, Neuropathology
, Tumor biology
, Pharmaceuticals - chemistry and drug development
, Applied molecular and cellular biology
Research keywords (13)：
Prolyl Isomerase Pin1
, Gas7
, p53
, c-Myc
, Tau
, microtubule
, polyphenols
, Alzheimer's disease
, Cancer
, Mesenchymal stem cells
, Prolyl isomerase Par14
, Protein Phosphorylation
, Uridine phosphorylase
Research theme for competitive and other funds (19)：
- 2014 - 2020 Prevention, diagnosis and drug discovery of aging diseases using Pin1 related molecules
- 2016 - 2019 Role of Pin1 in the development of pulmonary hypertension and therapeutic application
- 2015 - 2018 Is inducion of osteoblasts proliferation useful to treat the osteporosis patients?
- 2014 - 2017 Mechanisms of symbiotic evolution and N2O mitigation of soybean bradyrhizobia
- 2014 - 2017 Preparation for PTD-Pin1 and its appllication to stem cell differentiation
- 2013 - 2016 Development of agrochemical and pharmaceutical lead compounds based on the search and total synthesis of natural compounds with a unique structure and biological activity
- 2013 - 2015 Research for new polyphenols acting on aging-related enzymes and food development
- 2008 - 2013 Drug Discovery of Alzheimer Disease from Molecules- Regulating Microtubule Polymerization
- 2010 - 2012 Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds
- 2011 - Practical application research of "ADSC" for treatment and prevention of Alzheimer's disease
- 2004 - 2009 Regulation of Bio-nanosystems
- 2008 - 2008 プロリン異性化酵素を標的とした薬剤
- 2004 - 2008 Integrated Mechanism Regulating Phosphorylation- Dependent Signal Transduction
- 2004 - 2007 Analysis of the stress resistance functions of Prolyl Isomerase Pin1
- 2007 - Development of drug targeting prolyl isomerase for prevention of dementia
- 2003 - 2005 リン酸化蛋白質の構造を変化させる新規蛋白質の発見
- 2002 - 2003 プリオンを基質にするプロリルイソメラーゼの探索
- 2001 - 2003 Biological Activities of Protein Folding Enzyme
- 2000 - 2002 Preparation for single chain Fv
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Papers (129)：
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Valeria Righi, Martina Grosso, Renata Battini, Takafumi Uchida, Anna Gambini, Susanna Molinari, Adele Mucci. Metabolome in Tibialis and Soleus Muscles in Wild-Type and Pin1 Knockout Mice through High-Resolution Magic Angle Spinning 1H Nuclear Magnetic Resonance Spectroscopy. Metabolites. 2024. 14. 5. 262
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Hoshino Y, Uchida T. Prolyl isomerase, Pin1, controls meiotic progression in mouse oocytes. Cells. 2022. 11. 23. 3772
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Takahashi K, Uchida T, Higashi N, Kamei J. L-balenine inhibits the catalytic activity of Pin1, a peptidyl prolyl cis/trans-isomerase. Pers Med Univers,. 2020. 9. 51-58
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Shimizu T, Hirose K, Uchida C, Uchida T. Growth arrest specific protein 7 inhibits tau fibrillogenesis. Biochem. Biophys. Res. Commun. 2020. 526. 281-286
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Shimizu T, Kanai K, Sugawara Y, Uchida C, Uchida T. Prolyl isomerase Pin1 directly regulates calcium/calmodulin-dependent protein kinase II activity in mouse brains. Front Pharmacol. 2018. 9. NOV. 1351
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MISC (215)：
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Ohtaki H, Ono K, Tanaka M, Setoguchi Y, Hayashi A, Yoshikawa A, Kang D, Honda K, Kakita A, Uchida T. Amyloid-positive particles in pin1 KO mice are resemble with eosinophilic thalamic body in human. Society for Neuroscience. 2022
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柏木美麗, 橋本真祐, 高橋勝彦, 植松優希, 紺澤咲乃, 山本みな美, 中嶋彩乃, 内田隆史, 東伸昭. Retinoic acid regulates activation of AMPK in MCD-induced NASH. 日本薬学会年会要旨集(Web). 2022. 142年会. 26PO8-05S
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Gissi C, Zuccarelli L, Comelli M, Brocca L, Rossi M, Battini R, Uchida T, Pellegrino M.A, Bottinelli R, Grassi B, et al. Increased MtCK and ANT1 in aging Pin1 KO mice as a basis of augmented ADP sensitivity of mitochondrial respiration. 61th italian society of biochemistry and molecular biology. 2021
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岡田拓実, 内田千代子, 内田隆史. Analysis of Molecular Mechanism behind the effect of miso on the increase of resiliency. 中央味噌研究所研究報告. 2020. 41. 49-52
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大滝博和, 田中優希, 内田隆史, 桐山恵介, 本田一穂. Pin1KOマウスにおける視床に増加するβアミロイド陽性反応の経時的解析. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2020. 125th
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Patents (12)：
Books (4)：
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“Luminescence Biotechnology: Instruments and Applications”
CRC Press LLC (New York) 2002
-
Polymers in Medicine
Plenum Publishing Co. (New York) 1986
-
Macrophage Biology
Alan R. Liss, Inc. (New York) 1985
-
免疫実験操作法, XIII
1984
Education (4)：
- 1985 - The University of Tokyo, Graduate School Ph.D.
- 1977 - 1979 The University of Tokyo, Graduate School Applied Biochemistry MS
- 1975 - 1977 The University of Tokyo Biochemistry
- 1973 - 1975 The University of Tokyo Science
Professional career (1)：
- PhD (The University of Tokyo)
Work history (21)：
- 2019/04 - 現在 Tohoku University Emeritus Professor
- 2019/04 - 2025/03 Showa University School of Pharmacy visiting professor
- 2019/04 - 2025/03 Tokyo Kasei University
- 2019/04 - 2021/03 Hoshi University
- 2019/04 - 2020/03 Kanagawa University
- 2005/09 - 2019/03 Tohoku University Graduate School, Molecular Cell Science professor
- 2014/04 - 2018/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Lecturer (part-time)
- 2000/01 - 2018/03 Waseda University Advanced Research Institute for Science and Engineering visiting scientist
- 2007/04 - 2008/03 Nagoya University School of Science Department of Biological Science
- 2004/07 - 2008/03 Tohoku University Biomedical Engineering Research Organization Professor (Concurrent post)
- 2003/10 - 2006/03 Tohoku University Frontier Research Institute for Interdisciplinary Sciences Associate Professor (Concurrent post)
- 2000/01 - 2005/08 Tohoku University Institute of Development, Aging and Cancer Associate Professor
- 2002/09 - 2005/03 Hokkaido University School of Medicine Lecturer (part-time)
- 1999/04 - 1999/12 Waseda University Advanced Research Institute for Science and Engineering Professor
- 1998/06 - 1999/03 RIKEN
- 1992/09 - 1998/05 Roche Kamakura Research Section Head
- 1990/09 - 1992/08 F Hoffmann La Roche (AG)Basel Cancer Research Senior Researcher
- 1989/04 - 1990/08 Fuji Rebio Co. Central Research Center section head
- 1987/04 - 1989/03 Yale University School of Medicine Postdoctoral Associates
- 1979/04 - 1987/03 Toray Inc. Basic Research Laboratories Researcher
- 1985/03 - 1986/03 National Cancer Center, Research Institute Biology
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Committee career (7)：
Awards (4)：
- 2007/03 - 日本農芸化学会 研究企画賞 Search for phosphorylated protein-specific proline isomerase Pin1 regulator from natural products
- 2000/03 - AACR Scholar in Training Award
- 1987/04 - Yale Univ. SCM James Hudson Brown - Alexander B. Cox Fellowship
- 1984/09 - Basic Research Institute, Toray Industries The Best Patent, The best paper microbeads for biological tests
Association Membership(s) (7)：
日本生化学会
, 日本農芸化学会
, ASBMB
, 日本分子生物学会
, 日本癌学会
, American Association for Cancer Research
, Society for Neuroscience
