Kawahara Sachiyo

カワハラサチヨ | Kawahara Sachiyo

Affiliation and department：

Research field (3)： Experimental pathology , Immunology , Virology

Research keywords (6)：自然免疫 , 中和抗体 , ワクチン , レトロウイルス , viral infection , protective immunity

Research theme for competitive and other funds (13)：

2016 - 2019 The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia
2013 - 2016 Retroviral immune evasion
2012 - 2015 Mechanisms of regulation of host immune responses by retrovirus-restricting enzyme APOBEC3
2010 - 2012 The role of mouse APOBEC3 in the regulation of endogenous retrovirus
2009 - 2011 Regulation of APOBEC3 gene expression and its transcript splicing

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Papers (28)：

Tsukamoto T, Tsuji-Kawahara S, Miyazawa M. The mechanisms for leukemogenesis in Friend virus-infected mice. Bio Clinica. 2019. 34. 6. 629-635
Yoshiko Yasuda, Mitsugu Fujita, Eiji Koike, Koshiro Obata, Mitsuru Shiota, Yasushi Kotani, Terunaga Musha, Sachiyo Tsuji-Kawahara, Takao Satou, Seiji Masuda, et al. Erythropoietin Receptor Antagonist Suppressed Ectopic Hemoglobin Synthesis in Xenografts of HeLa Cells to Promote Their Destruction. PLOS ONE. 2015. 10. 4
Maiko Kato, Sachiyo Tsuji-Kawahara, Yuri Kawasaki, Saori Kinoshita, Tomomi Chikaishi, Shiki Takamura, Makoto Fujisawa, Akira Kawada, Masaaki Miyazawa. Class Switch Recombination and Somatic Hypermutation of Virus-Neutralizing Antibodies Are Not Essential for Control of Friend Retrovirus Infection. JOURNAL OF VIROLOGY. 2015. 89. 2. 1468-1473
Shiki Takamura, Eiji Kajiwara, Sachiyo Tsuji-Kawahara, Tomoko Masumoto, Makoto Fujisawa, Maiko Kato, Tomomi Chikaishi, Yuri Kawasaki, Saori Kinoshita, Manami Itoi, et al. Infection of Adult Thymus with Murine Retrovirus Induces Virus-Specific Central Tolerance That Prevents Functional Memory CD8(+) T Cell Differentiation. PLOS PATHOGENS. 2014. 10. 3. e1003937
Sachiyo Tsuji-Kawahara, Masaaki Miyazawa. Elimination of Friend Retrovirus in the Absence of CD8(+) T Cells. JOURNAL OF VIROLOGY. 2014. 88. 3. 1854-1855

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MISC (24)：

C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa. Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 817-817
Masaaki Miyazawa, Yoshiyuki Hakata, Eri Takeda, Jun Li, Sachiyo Tsuji-Kawahara. Functional polymorphisms and molecular evolution of mouse APOBEC3. Seikagaku. 2016. 88. 5. 582-592
河原佐智代, 川崎ゆり, 本園千尋, 高村史記, 宮澤正顯. B細胞固有TLR7シグナル伝達はレトロウイルス感染後の組換えウイルス産生防止にとって必要である. 日本免疫学会総会・学術会記録. 2015. 44. 64
Masaaki Miyazawa, Sachiyo Tsuji-Kawahara, Tomomi Chikaishi, Maiko Kato, Shiki Takamura. Mouse APOBEC3 affects the production of virus-neutralizing antibodies by restricting early retroviral replication, not by altering the B-cell repertoire. RETROVIROLOGY. 2009. 6
Masaaki Miyazawa, Sachiyo Tsuji-Kawahara, Yasuyoshi Kanari. Host genetic factors that control immune responses to retrovirus infections. VACCINE. 2008. 26. 24. 2981-2996

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Lectures and oral presentations (16)：

Production of virus-neutralizing antibodies and protection against lethal retroviral infection in AID-deficient mice.
(2011)
Polymorphisms in mouse APOBEC3 influence the production of virus-neutralizing antibodies by altering the levels of retrovirus-induced B-cell dysfunction
(2010)
Polymorphisms of both APOBEC3 and BAFF-R affect the production of retrovirus-neutralizing antibodies
(2009)
生理的に発現するマウスAPOBEC3アイソフォームのフレンド白血病ウイルス複製抑制活性
(第55回日本ウイルス学会学術集会 2007)
MHC as immune resistance genes against mouse retroviral infections:their mechanisms of action
(2005)

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Education (3)：

Professional career (1)：

Work history (4)：

Association Membership(s) (3)：

アメリカ微生物学会 , 日本分子生物学会 , 日本免疫学会

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