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J-GLOBAL ID：200901065276970804   Update date: Oct. 09, 2024

Sakurai Kazumasa

サクライ カズマサ | Sakurai Kazumasa
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Affiliation and department：
Kindai University Institute of Advanced Technology

About Kindai University Institute of Advanced Technology


Job title： Associate Professor
Research field  (1)： Biophysics
Research keywords  (8)： Methylotrophic yeast ,  アロステリック ,  amyloid ,  Dynamics ,  biophysics ,  NMR ,  protein folding ,  protein
Research theme for competitive and other funds  (10)：
  • 2022 - 2025 新規アロステリック薬発見を目指したガン糖代謝関連タンパク質の動的分子構造解析
  • 2020 - 2023 「健康長寿・未病効果が期待できる新たな機能性食品の開発をめざした実践研究」
  • 2015 - 2018 Mechanism and regulation of protein aggregation in complicated cellular systems
  • 2015 - 2017 Experimental verification of hidden amyloidogenicity of proteins
  • 2015 - 2017 Thermodynamic analysis of pressure- and temperature-dependent structural changes of amyloid fibril and its oligomeric intermediates
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Papers (45)：
  • Ryosuke Tomiyama, Masatomo So, Yohei Miyanoiri, Kazumasa Sakurai. The Residual Structure of Acid-Denatured Β2-Microglobulin is Relevant to an Ordered Fibril Morphology. SSRN Electronic Journal. 2022. 32. 1
  • Kazumasa Sakurai, Ryosuke Tomiyama. Enhanced accessibility and hydrophobicity of amyloidogenic intermediates of the β2-microglobulin D76N mutant revealed by high-pressure experiments. Journal of Biological Chemistry. 2021. 296. 100333-100333
  • Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, et al. Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism. Current Research in Structural Biology. 2020. 2. 35-44
  • Hiroya Muta, Masatomo So, Kazumasa Sakurai, Jozsef Kardos, Hironobu Naiki, Yuji Goto. Amyloid Formation under Complicated Conditions in Which β2-Microglobulin Coexists with Its Proteolytic Fragments. Biochemistry. 2019
  • Noji M, Sasahara K, Yamaguchi K, So M, Sakurai K, Kardos J, Naiki H, Goto Y. Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH. The Journal of biological chemistry. 2019. in press. 43. 15826-15835
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MISC (20)：
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Books (6)：
  • NMRによる有機材料分析とその試料前処理、データ解釈
    技術情報協会 2021 ISBN:9784861048609
  • タンパク質相転移の礎:フォールディング
    東京化学同人 2020 ISBN:9784807913466
  • タンパク質に対する圧力研究の新展開 ー基本熱力学から、分子構造に基づく理解、アミロイド線維まで
    化学同人 2020
  • Molecular Structure of Amyloid Fibrils Revealed by Thermodynamics
    Nova Science Publishers 2016 ISBN:9781634859707
  • アミロイド線維の構造と形成機構-研究の歴史と現在の試み
    化学同人 2013
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Lectures and oral presentations  (139)：
  • Akkermansia muciniphila由来GH27/GH97α-galactosidaseの機能解析
    (日本応用糖質科学会2024年度大会(第73回) 2024)
  • Detection method for inter-residue concerted conformational change in a protein molecule by analyzing perturbation-induced multi-dimensional chemical shift changes
    (the 30th International Conference on Magnetic Resonance in Biological Systems 2024)
  • Study on the Inhibitory Effect of Plant Leaf Extracts on Amyloid Fibril Formation of β2-Microglobulin
    (The Annual Plant Biology Meeting 2024)
  • ガン関連小胞体タンパク質ENTPD5の糖鎖によるアロステリック制御
    (第24回日本蛋白質科学会年会 2024)
  • 高圧NMRによる新型コロナウイルス受容体結合ドメインの構造特性の解析
    (第24回日本蛋白質科学会年会 2024)
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Education (3)：
  • 2002 - 2005 大阪大学大学院 博士後期課程 理学研究科 高分子科学専攻
  • 2000 - 2002 大阪大学大学院 博士前期課程 理学研究科 高分子科学専攻
  • 1996 - 2000 Osaka University School of Science Department of Chemistry
Professional career (1)：
  • Docter (Science) (Osaka University)
Work history (4)：
  • 2016/04 - 現在 Kinki Univ. Inst. Advanced Tecnol. Associate Professor
  • 2016/04 - 2018/03 Osaka University Institute for Protein Research Division of Protein Structural Biology
  • 2013/04 - 2016/03 Kinki Univ. Inst. Advanced Tecnol. Lecturer
  • 2005/04 - 2013/03 Osaka Univ. Inst. Protein Res. Assist. Prof.
Committee career (3)：
  • 2021/12 - 現在 日本高圧学会 「高圧力の科学と技術」編集委員
  • 2023/09 - 2024/09 第24回若手NMR研究会 企画委員
  • 2016/09 - 2017/09 若手NMR研究会 第18回若手NMR研究会世話人
Association Membership(s) (4)：
THE JAPAN SOCIETY OF HIGH PRESSURE SCIENCE AND TECHNOLOGY ,  The Nuclear Magnetic Resonance Society of Japan ,  The Protein Science Society of Japan ,  The Biophysical Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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