Rchr
J-GLOBAL ID:200901065276970804   Update date: Aug. 30, 2020

Sakurai Kazumasa

サクライ カズマサ | Sakurai Kazumasa
Research field  (1): Basic physical chemistry
Research keywords  (1): protein folding NMR biophysics
Research theme for competitive and other funds  (3):
  • 2009 - 2010 Characterization of the transient intermediate of the β2-microglobulin amyloid fibril using solution NMR techniques
  • 2007 - 2008 Structural analysis of growing-end intermediate of amyloid fibril using NMR
  • 2002 - 2005 Study on high-order structure formation of protein
Papers (46):
  • Noji M, Sasahara K, Yamaguchi K, So M, Sakurai K, Kardos J, Naiki H, Goto Y. Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH. The Journal of biological chemistry. 2019. in press
  • Sakurai K, Tomiyama R, Shiraki T, Yonezawa Y. Loosening of side-chain packing associated with perturbations in peripheral dynamics induced by the D76N mutation of β2-microglobulin revealed by pressure-NMR and molecular dynamic simulations. Biomolecules. 2019. 9. 9. 491
  • Sakurai K, Maeno A, Lee YH, Akasaka K. Conformational Properties Relevant to the Amyloidogenicity of beta2-Microglobulin Analyzed Using Pressure- and Salt-Dependent Chemical Shift Data. The Journal of Physical Chemistry B. 2019. 123. 4. 836-844
  • Ayame Nitani, Hiroya Muta, Masayuki Adachi, Masatomo So, Kenji Sasahara, Kazumasa Sakurai, Eri Chatani, Kazumitsu Naoe, Hirotsugu Ogi, Damien Hall, Yuji Goto. Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 52. 21219-21230
  • Sakurai, K, Yagi, M, Konuma, T, Takahashi, S, Nishimura, C, Goto, Y. Non-Native alpha-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the beta-Barrel in beta-Lactoglobulin. Biochemistry. 2017
more...
MISC (10):
Books (3):
  • Molecular Structure of Amyloid Fibrils Revealed by Thermodynamics
    Nova Science Publishers 2016 ISBN:9781634859707
  • アミロイド線維の構造と形成機構-研究の歴史と現在の試み
    化学同人 2013
  • フォールディング入門-タンパク質の構造や機能の基盤
    羊土社 2007
Lectures and oral presentations  (68):
  • Heating-induced amyloid formation of b2-microglobulin at neutral pH
    (The 57th annual meeting of the Biophysical Society of Japan 2019)
  • Amyloid Fibrillation under complexity with coexisting b2-microglobulin and its proteolytic fragments
    (The 19th annual meeting of Protein Science Society Japan 2019)
  • Analysis of pH/pressure-dependent structural changes of a-synuclein based on chemical shift data
    (The 19th annual meeting of Protein Science Society Japan 2019)
  • The mechanism of structural dynamics perturbations by the D76N mutation of β2-microglobulin revealed by pressure-NMR and MD simulations
    (BK 21 PLUS-SKKU SYMPOSIUM“Cellular/Molecular Neuroscience and Human Disease” 2019)
  • Analyses of pH/pressure-dependent structural changes of α-synuclein by chemical shift data
    (Ulm Meeting - Biophysics of Amyloid Formation 2019)
more...
Education (3):
  • - 2002 Osaka University graduate school of science macromolecular science
  • 1996 - 2000 Osaka University School of Science Department of Chemistry
  • - 2000 Osaka University School of Science Department of Chemisty
Work history (1):
  • 2005/04 - 2013/03 Osaka Univ. Assist. Prof.
Association Membership(s) (4):
THE JAPAN SOCIETY OF HIGH PRESSURE SCIENCE AND TECHNOLOGY ,  The Nuclear Magnetic Resonance Society of Japan ,  The Protein Science Society of Japan ,  The Biophysical Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page