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J-GLOBAL ID：200901078512065209 Update date: Mar. 14, 2025

Hattori Nobutaka

ハットリノブタカ | Hattori Nobutaka

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Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/80218510

Research field (4)： Neurology , Pharmacology , Pharmaceuticals - health and biochemistry , Neuroscience - general

Research keywords (36)： iPLA2-VIA/ PLA2G6 , α-synuclein seed , PSAP , iPSC , Telemedicine , CHCHD2 , 包括脳ネットワーク , パーキンソン病 , 家族性パーキンソン病 , PINK1 , DJ-1 , パーキン , LRRK2 , parkin , α-シヌクレイン , ミトコンドリア , 発症機序 , 遺伝性パーキンソン病 , ユビキチン・プロテアソーム系 , PINK1遺伝子 , CDCrel-1 , 神経細胞死 , ユビキチンリガーゼ , Lewy小体 , 若年性パーキンソン病 , ユビキチン , 複合体I , パーキン遺伝子 , DJ-1遺伝子 , AR-JP , ubiquitin-proteasome系 , ubiquitin ligase , Lewy body , 蛋白分解系 , ドパミン自動酸化 , 14-3-3η

Research theme for competitive and other funds (59)：

2023 - 2031 脳データ統合プラットフォームの開発と活用による脳機能と疾患病態の解明
2023 - 2030 Interdisciplinary research on autophagy: From working principles to pathophysiology
2024 - 2029 レヴイ小体構成蛋白α-シヌクレインの伝播・凝集機序解明と革新的進行阻止療法の開発
2023 - 2026 神経変性疾患領域における難病の医療水準の向上や患者のQOL向上に資する研究
2023 - 2026 孤発性パーキンソン病iPS細胞ライブラリーを活用した治療薬探索

2023 - 2026 希少難病に対するN-of-1+核酸医薬創薬研究

2021 - 2024 Elucidation of transmission and aggregation mechanisms of alpha-synuclein as a major component of Lewy body and development of disease-modifying therapies for synucleinopathies

2019 - 2022 Pathogenesis role of programmed cell death-1 in Parkinson's disease mouse model

2018 - 2021 Elucidation of the mechanisms of the Parkinson's disease genes and Lewy Body formation and alpha-synuclein propagation mechanisms

2017 - 2020 難治性疾患等を対象とする持続可能で効率的な医療の提供を実現するための医療経済評価の手法に関する研究

2015 - 2018 Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology

2015 - 2018 Role of the gut microbiota in acute cerebral ischemia

2014 - 2018 A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

2014 - 2018 Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products

2013 - 2018 Development of autophagy enhancing chemicals based on Parkinson's disease pathogenesis.

2014 - 2017 Clinical Analysis of Neurodegenerative Dementia Using Cerebrospinal Fluid Biomarkers

2014 - 2017 Development of DBS programming based on local field potential analysis

2013 - 2017 The detection of modifier gens in alpha-synuclein multiplications

2013 - 2016 Phosphorylated recombinant HSP27 as a new neuroprotective agent for acute ischemic stroke

2011 - 2016 Brain Environment

2011 - 2016 Mechanisms of the inclusion body formation in the brain: Association of an inclusion body and the neuronal cell death

2012 - 2015 Autophagy lysosomal dysfunction associate with the pathogenesis of early onset Parkinson's disease.

2012 - 2015 Basic research to establish novel therapy for Parkinson disease using neuromodulation

2011 - 2015 Randomized, double-blind, placebo-controlled trial of reduced form of coenzyme Q10 of Parkinson's disease

2014 - 2014 パーキンソン病の代謝産物バイオマーカー創出およびその分子標的機構に基づく創薬シーズ同定

2012 - 2012 Development of the new cerebral infarction therapy by HSP27 protein

2010 - 2012 The clinical investigation towards the rehabilitation effect on Parkinson's disease

2011 - 2011 オートファジー破綻におけるシナプス機能不全のメカニズム

2009 - 2011 Gnentic analysis to identify new causative genes in autosomal dominant Parkinson's disease

2009 - 2011 Generation of pathological models for Parkinson's disease

2009 - 2010 Effects of mitophagy on cell death in Parkinson's disease model cells

2008 - 2010 Analyses of responsible protein for familial Parkinson's disease in lipid rafts.

2008 - 2009 To elucidate the pathogenesis of Parkinson' s disease and to develop a new therapy for the disease

2005 - 2009 パーキンソン病における神経細胞死の機序解明とその防御

2005 - 2009 Search for Parkinson-related genes and their functional analysis

2007 - 2008 Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for

2007 - 2008 Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan

2007 - 2008 パーキンソン病における蛋白分解系の関与

2006 - 2007 Functional analyses of the responsible proteins for familial Parkinson's disease in association with lipid rafts

2005 - 2006 New therapy for cerebral infarction targeting of the control of mutant ubiquitin 1 (UBB+1) producted by RNA editing

2005 - 2006 PINK1 gene and DJ-1 gene mutation analysis about juvenile Parkinson's disease.

2005 - 2006 Analysis on aggregation formation by novel Lewy body component Siah-1 complementary to Parkin

2005 - 2006 The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease gene

2003 - 2004 Linkage analysis for novel gene cause of familial Parkinson's disease

2003 - 2004 IDENTIFICATION AND CHARACTERIZATION OF A NOVEL UBIQUITIN LIGASE SIAH THAT EXHIBITS COMPLEMENTARY ROLES WITH PARKIN

2003 - 2004 Mutational and functional analysis for Familial Parkinson's disease

2001 - 2004 MUTATIONAL ANALYSIS OF THE PARKIN GENE AND FUNCTIONAL ANALYSIS OF THE PARKIN PROTEIN

2001 - 2003 パーキンソン病の遺伝的背景の解析

2001 - 2002 Mutation and functional analysis of parkin responsible for AR-JP

2001 - 2002 ユビキチンリガーゼとしてのパーキン蛋白の機能解析

2000 - 2000 若年性パーキンソンニズム(AR-JP)の原因遺伝子産物パーキン蛋白質の機能解析及び遺伝子変異解析

1999 - 2000 The Expression of Parkin as a Pathogenic Gene for Autosomal Recessive Juvenile Parkinsonism and Its Physiological Role

1999 - 2000 Mutational and functional analyses of the parkin responsible for AR-JP

1999 - 2000 Reseach for Gene therapy of ARJP

1998 - 2000 GENETIC BACKGROUND OF SPORADIC PARKINSON'S DISEASE

1999 - 1999 パーキンソン病におけるユビキチン様蛋白質の意義

1997 - 1998 パーキンソン病の遺伝的素因に関する研究:ミトコンドリア電子伝達系複合体I24-kDa,51-kDa subunits遺伝子異常について

1996 - 1996 パーキンソン病の遺伝的素因に関する研究

1994 - 1994 パーキンソン病におけるミトコンドリア蛋白遺伝子異常

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Papers (1,510)：

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Masaki Hiramoto, Satoru Yamagishi, Takayasu Mishima, Shin'ichiro Yasunaga, Yoshio Tsuboi, Nobutaka Hattori, Jane Y Wu. Neuronal guidance signaling in neurodegenerative diseases: key regulators that function at neuron-glia and neuroimmune interfaces. Neural regeneration research. 2025
Emi Furusawa-Nishii, Bataa Solongo, Kou Rai, Soichiro Yoshikawa, Asako Chiba, Ayami Okuzumi, Shin-Ichi Ueno, Yasunobu Hoshino, Yoko Imamichi-Tatano, Haruka Kimura, et al. α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson's disease. Journal of neuroinflammation. 2025. 22. 1. 38-38
Tomoyo Shimada, Anri Sakurai, Shunichi Niiyama, Kaito Kawamura, Madoka Nakajima, Ayami Okuzumi, Taku Hatano, Masakazu Miyajima, Nobutaka Hattori, Taiji Tsunemi. Idiopathic normal pressure hydrocephalus concomitant with progressive supranuclear palsy. Parkinsonism & related disorders. 2025. 132. 107273-107273
Taiji Tsunemi, Yuta Ishiguro, Asako Yoroisaka, Dou Feng, Tomoyo Shimada, Shunichi Niiyama, Yukiko Sasazawa, Keiichi Ishikawa, Wado Akamatsu, Nobutaka Hattori. Alpha-synuclein inhibits the secretion of extracellular vesicles through disruptions in YKT6 lipidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025
Muneaki Kikuno, Yuji Ueno, Yohei Tateishi, Ayako Kuriki, Ryosuke Doijiri, Takahiro Shimizu, Hidehiro Takekawa, Kodai Kanemaru, Yoshiaki Shimada, Eriko Yamaguchi, et al. Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke. Journal of atherosclerosis and thrombosis. 2024

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MISC (1,310)：

奥住文美, 波田野琢, 服部信孝. αシヌクレインに焦点を当てた診断バイオマーカーの開発 : 新しい生物学的病期分類の構築に向けて : Parkinson病-特集今この研究が面白い! ; 神経. 内科 = Internal medicine : 臨床雑誌. 2024. 134. 3. 677-681
奥住文美, 波田野琢, 服部信孝. Parkinson病のバイオマーカー-Biological biomarkers for Parkinson disease-特集 Parkinson病 : 臨床と研究の新展開(その1). 脳神経内科 = Neurology / 脳神経内科編集委員会編. 2024. 100. 3. 268-273
平澤恵理, 小川崇, 服部信孝. 脳神経内科診療においてDE&Iを支えるために必要な取り組みの現在と未来. 日本神経学会学術大会プログラム・抄録集. 2024. 65th
星野泰延, 萩原彰文, 富沢雄二, 仲谷元, 横山和正, 鎌形康司, 青木茂樹, 服部信孝. MS,NMOSD,抗MOG抗体関連疾患に対するmyelin- and axon-sensitive MRIによる評価. 日本神経学会学術大会プログラム・抄録集. 2024. 65th
仲谷元, 萩原彰文, 星野泰延, 富沢雄二, 神尾諭, 鎌形康司, 和田昭彦, 堀正明, 阿部修, 服部信孝, et al. Synthetic MRIによる多発性硬化症の脳室周囲勾配変化の検討. 日本神経放射線学会プログラム・抄録集. 2024. 53rd

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Patents (45)：

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Books (14)：

順天堂大脳神経内科ではこうしている最新パーキンソン病診療 : 専門医はここで悩み、こう解決する
日本医事新報社 2021 ISBN:9784784949502
パーキンソン病における疾患修飾療法の可能性、新たな治療法、パーキンソン病を解剖する、過去・現在、そして未来へ、
医歯薬出版株式会社、東京 2021
パーキンソン病における疾患修飾療法の可能性、新たな治療法、パーキンソン病を解剖する、過去・現在、そして未来へ、医学のあゆみ 278(10):920-925, 2021
医歯薬出版株式会社 2021
パーキンソン病の分子遺伝学-家族性パーキンソン病、基礎研究の進展、パーキンソン病を解剖する、過去・現在、そして未来へ
医歯薬出版株式会社 2021
ウルトラ図鑑パーキンソン病上手にコントロールするための知識と対処法、オールカラー家庭の医学、総ページ数160、令和2年6月19日第1版発行
株式会社法研 2020

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Lectures and oral presentations (65)：

Challenge of OFF- time, A Symposium sponsored by Bial, "How are we really optimising Levodopa? - the role of the enzymatic inhibition"
(A Symposium sponsored by the Bial, at the International Congress of Parkinson’s Disease and Movement Disorders, Copenhagen, Denmark 2023)
[LS-23-1] パーキンソン病の全貌を明らかにする【ランチョンセミナー】
(第64回日本神経学会学術大会、幕張メッセ、2023年6月1日、千葉 2023)
講演2 ゲノム医療を活用した神経難病の進行阻止を目指して
(第31回日本医学会総会2023東京、市民公開講座「ビッグデータが拓く難病医学の未来」 2023)
Speaker 1, Emerging Biomarkers of Parkinson Disease, Session: Movement Disorders, the Fourth International Taiwanese Congress of Neurology (4th ITCN), Apr. 14-16(Apr 15), 2023, Taiwan
(the Fourth International Taiwanese Congress of Neurology (4th ITCN) 2023, Taiwan 2023)
Speaker 2,, Session: Plenary Session,
(2023)

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Education (3)：

1990 - 1994 Juntendo University Graduate School of Medicine
1990 - 1993 Nagoya University School of Medicine
1985 - Juntendo University Faculty of Medicine

Work history (11)：

2024/04 - 現在 Juntendo University Advisor to the University President
2020/10 - 現在国立研究開発法人理化学研究所脳神経科学研究センター神経変性疾患連携研究チームチームリーダー併任
2006 - 現在 Juntendo University Faculty of Medicine
2019/04 - 2024/03 Juntendo University Faculty of Medicine
2020/10 - 国立研究開発法人理化学研究所脳神経科学研究センター(併任) 神経変性疾患連携研究チームチームリーダー

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Awards (16)：

2025/03 - The Japan Academy Japan Academy Prize Unraveling the Pathogenesis of Parkinson's Disease through Genetic Analysis
2024/11 - Takeda Science Foundation The Takeda Prize for Medical Science
2024/05 - Tokizane Toshihiko Prize
2023/08 - The International Parkinson and Movement Disorder Society (MDS) The Honorary Membership Award, the MDS Congress, Copenhagen
2022/09 - The International Parkinson and Movement Disorder Society (MDS)/International Congress 2022, Madrid, Spain C. David Marsden Lecture Award Challenge to Elucidate-the Pathomechanisms of Parkinson’s Disease: From the Pathogenesis to Biomarkers

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Association Membership(s) (22)：

日本免疫学会 , American Academy of Neurology , La Sociedad Española de Neurologia; Miembro Numerario de Honor , International Association of Parkinsonism and Related Disorders (IAPRD), Executive member , American Neurological Association , Parkinson and Movement Disorder Society , JAPAN SOCIETY FOR EQUILIBRIUM RESEARCH , JAPANESE SOCIETY FOR APHERESIS , THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE , THE JAPANESE SOCIETY OF NEUROPATHOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPAN NEUROSCIENCE SOCIETY , 日本神経感染症学会 , 日本神経精神薬理学会 , JAPAN SOCIETY FOR DEMENTIA RESEARCH , 日本在宅医学会 , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE , 日本神経治療学会 , MDSJ , JAPANESE SOCIETY OF NEUROLOGY

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