Rchr

J-GLOBAL ID：200901079105256594 Update date: Oct. 31, 2024

Ohya Susumu

オオヤススム | Ohya Susumu

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.nagoya-cu.ac.jp/med/labo/pharma/index.html , http://www.med.nagoya-cu.ac.jp/pharma.dir/index.html

Research field (1)： Pharmacology

Research keywords (3)：イオンチャネル , 病態分子薬理学 , Pharmacology

Research theme for competitive and other funds (41)：

2022 - 2026 Pathophysiological role of potassium channels in immunosuppressive cells
2020 - 2024 Pathological significance of K+ channel regulation in tumor microenvironment
2018 - 2023 Pathophysiological functions of ion channels in the chronic inflammatory and fibrotic disorders
2019 - 2021 カリウムチャネルを分子標的とした炎症性腸疾患に関する研究
2016 - 2019 Role of Mrgpr in itch associated with atopic dermatitis

2016 - 2019 Molecular mechanisms underlying alternation of ion channel expression and function by chronic inflammation

2017 - 2018 カリウムチャネル阻害による抗炎症性サイトカインIL-10産生増大機構の解明

2014 - 2016 The androgen receptor regulates Ca2+-activated K+ channels KCa2.2 in Prostate Cancer.

2015 - 2016 Tリンパ球におけるtwo-pore型K+チャネルK2P5.1の生理的役割とその新規阻害機構の解明

2013 - 2016 Acid-sensitive K+ channels as threrapeutic targets for immune diseases and cancers

2014 - 2015 カリウムチャネル新規阻害機構の解明

2011 - 2014 Positive feedback mechanism for the regulation of intracellular Ca2+ concentration and related ion channels as novel drug targets

2012 - 2013 ストレス応答性調節におけるリンパ球Ca2+活性化K+チャネルKCa3.1の役割

2012 - 2013 免疫シナプスにおけるTwo-pore domain K+チャネル輸送機構の解明

2011 - 2013 カルシウム活性化カリウムチャネルの新規発現調節機構とその創薬への応用

2011 - 2012 炎症性疾患におけるTリンパ球カリウムチャネル活性・発現調節

2011 - 2012 Development of recombinant cell lines dying upon single action potentialoccurrence and the new screening system for compounds acting on ion channels

2009 - 2011 カルシウム活性化カリウムチャネルの新規発現調節機構とその創薬への応用

2009 - 2011 Regulation of the dominant-negative-isoform of Ca^<2+>-activated K^+channel K_<Ca> 3.1 and its role in various diseases

2008 - 2010 Novel molecular functions of calcium-activated potassium channel as a target of drug development

2008 - 2009 トランスポートソームにおけるイオンチャネル局在と関連分子間協関の可視化解析

2007 - 2008 Clarification of erectile function in injured men with arteriogenic erectile dysfunction.-The establishment of a new drug therapy-

2006 - 2007 ミトコンドリアK^+チャネルを標的とした神経・心筋細胞保護の分子機構解明

2006 - 2007 トランスポートソームによるペースメーカー活動の発生・調節機構

2005 - 2007 Analyses of calcium-activated potassium channels as novel targets for new drug therapy

2005 - 2006 生細胞内オルガネラ膜上タンパク質の一分子可視化技術の開拓

2004 - 2005 K^+チャネル電位依存性制御の分子機構解明と電位依存性K^+チャネル開口薬の探索

2003 - 2004 新規メカニズムによるイオンチャネル作用薬の効率的探索法の開発

2002 - 2004 The regulation of ion channel activity by intracellular Ca2+ dynamics and survey of candidate molecules available for therapy of related diseases

2002 - 2003 電位依存性カリウムチヤネル機能制御分子と平滑筋機能異常

2000 - 2001 妊娠子宮平滑筋におけるK^+チャネル発現変化に関する遺伝子工学的解析

1999 - 2000 細胞内情報伝達系における局所Ca^<2+>動態の画像解析とイオンチャネル活性化制御

1998 - 1999 The mechanisms underlying nonspecific supersensitivity induced by parasympathetic denervation in rat iris sphincter

1998 - 1999 Molecular analysis and sensitivity to arachidonic acid of voltage-dependent KィイD1+ィエD1 channel, Kv4.3

1998 - 1999 EXPRESSION OF IONIC CHANNELS DURING CARDIOVASCULAR DISEASE

1996 - 1997 Molecular analysis of muscarinic receptors and regulation mechanism of dilation in the rat iris.

1996 - 1997 Molecular Diversity of K Channels in Cardiovascular System.

1994 - 1995 Molecular piolcgical analysises of muscarinic receptore in the rat iris dilator

1994 - 1995 Molecular biology of vascular and cordiac k channels

イオンチャネル病

Molecular Pharmacology of ion channels

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Papers (146)：

Miki Matsui, Junko Kajikuri, Hiroaki Kito, Elghareeb E. Elboray, Takayoshi Suzuki, Susumu Ohya. Downregulation of IL-8 and IL-10 by LRRC8A Inhibition through the NOX2-Nrf2-CEBPB Transcriptional Axis in THP-1-Derived M₂ Macrophages. International Journal of Molecular Sciences. 2024
Susumu Ohya, Hiroaki Kito, Junko Kajikuri, Yohei Yamaguchi, Miki Matsui. Transcriptional Up-Regulation of FBXW7 by KCa1.1 K+ Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. International Journal of Molecular Sciences. 2024. 25. 11. 6019-6019
Yuji Hotta, Kyoya Oyama, Takuma Yoshida, Naoya Ieda, Taiki Mori, Yasuhiro Horita, Tomoya Kataoka, Yoko Furukawa-Hibi, Susumu Ohya, Hidehiko Nakagawa, et al. The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus. The World Journal of Men's Health. 2024. 42
Hiroaki Kito, Reiko Kawagishi, Takusei Ryu, Kyoko Endo, Junko Kajikuri, Wayne R. Giles, Susumu Ohya. KCa3.1 regulates cell cycle progression by modulating Ca2+ signaling in murine preosteoblasts. Journal of Pharmacological Sciences. 2023. 153. 3. 142-152
Susumu Ohya, Junko Kajikuri, Hiroaki Kito, Miki Matsui. Down-Regulation of CYP3A4 by the K_Ca1.1 Inhibition Is Responsible for Overcoming Resistance to Doxorubicin in Cancer Spheroid Models. International Journal of Molecular Sciences. 2023

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MISC (179)：

松井未来, 梶栗潤子, 遠藤京子, 鬼頭宏彰, 大矢進. Increase in IL-10 expression by K_Ca3.1 inhibition in peripherally-induced regulatory T cells. 日本薬学会年会要旨集(Web). 2022. 142nd
OHYA Susumu, KAJIKURI Junko, ENDO Kyoko, KITO Hiroaki. Role of Ca²⁺-activated K⁺ channel K_Ca1.1 in in vitro model of tumor microenvironment. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
遠藤京子, 遠藤京子, 鬼頭宏彰, 梶栗潤子, 大矢進. マウスCD4陽性細胞におけるHIF-1αを介したpH感受性カリウムチャネルK_2p5.1転写制御. 次世代を担う創薬・医療薬理シンポジウムプログラム・要旨集. 2019. 2019
OHYA Susumu, KAJIKURI Junko, KITO Hiroaki. Transcriptional repression of IL-10 by K+ channel activators in human T-cell lymphoma HuT-78 cells. 日本癌学会学術総会抄録集(Web). 2018. 77th
Y. Imaizumi, M. Inayama, Y. Suzuki, T. Kurita, S. Ohya, W. Giles, H. Yamamura. ORAI1-ORAI2-STIM1 COMPLEX INDUCES STORE-OPERATED CALCIUM ENTRY IN CHONDROCYTES. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014. 115. 271-271

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Books (3)：

eReview薬理学
Elsevier Japan KK 2020
医療薬学III
東京化学同人 2017
Pharmacology
2015

Education (3)：

1994 - 1995 Nagoya City University
1992 - 1994 Nagoya City University Graduate School of Pharmaceutical Sciences
1988 - 1992 Nagoya City University Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D. (Nagoya City University)

Work history (4)：

2017/09 - 現在 Nagoya City University Graduate School of Medical Sciences Professor
2012/04 - 2017/08 Kyoto Pharmacutical University Faculty of Pharmaceutical Sciences Professor
2005/04 - 2012/03 Nagoya City University Graduate School of Pharmaceutical Sciences Associated Professor
1995/04 - 2005/03 Nagoya City University Graduate School of Pharmaceutical Sciences Asistant Professor

Committee career (6)：

2021/12 - 現在 Frontiers in Physiology, Cell Physiology section Associate Editor
2020/04 - 現在 Editor
2020/04 - 現在日本薬理学会広報委員会
2001 - 現在日本薬理学会学術評議員
2018/04 - 2020/03 日本薬理学会企画教育委員

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Awards (2)：

2006 - 日本薬学会奨励賞(平成18年度)
2005 - 最優秀ポスター発表賞(US-Jpan Conference on Drug Development & Rational Drug Design)

Association Membership(s) (9)：

THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE JAPANESE CANCER ASSOCIATION , American Physiological Society , 日本生理学会 , 日本薬剤師会 , Physiological Society , Biophysical Society , 日本薬学会 , 日本薬理学会

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