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J-GLOBAL ID：200901080629944844 Update date: Dec. 11, 2024

Miyake Koichi

ミヤケコウイチ | Miyake Koichi

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Affiliation and department：

Research field (2)： Hematology and oncology , Molecular biology

Research keywords (1)： Gene Therapy, Hypophosphatasia

Research theme for competitive and other funds (32)：

2023 - 2027 AI advice for effective PBL assignment creation -Development of assignment writing support tools-
2020 - 2023 Development of gene therapy for hypophosphatasia
2019 - 2023 機械学習で議事録を分析:PBLチュートリアルチューター支援システムの開発
2018 - 2020 脳神経病変を標的とした異染性白質ジストロフィーの新規治療法(遺伝子治療)の開発
2017 - 2019 Biomarker development and clinical application by extraction of pathogenesis-related factors from early fibrosis foci of interstitial pneumonia

2016 - 2018 The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenita

2014 - 2017 MicroRNA and exosome in interstitial pneumonia

2015 - 2017 The gene therapy for hypophosphatasia animal model

2015 - 2017 Development a novel gene therapy for Lysosomal disease with neurological disorders

2014 - 2017 Development of mouse model and therapy of Diamond-Blackfan anemia

2013 - 2016 Comprehensive analysis of neuropathic pain-specific microRNA cluster

2014 - 2016 Elucidation of molecular mechanism of survivin in inflammatory lung disease and development of new gene therapy method

2011 - 2015 Physiological function of the rat SDN-POA analyzed by sst-siRNA recombinant adenovirus vector

2013 - 2015 Development of regenerative medicine and cell therapy for inherited metabolic diseases using hypophosphatasia mice

2013 - 2015 Analysis of lymphoplasmacyte infiltrating fibrotic lung lesion using samples from human lung diseases and RA lung model in D1CC mice

2012 - 2014 Development of novel gene therapy for CNS disorders of lysosomal diseases

2011 - 2013 Analysis of angiogenetic factor in interstitial pneumonia

2011 - 2013 Development of molecular mechanism and therapy of Diamond-Blackfan anemia

2010 - 2012 Perinatal gene therapy for severe genetic diseases

2010 - 2012 The novel gene therapy using adeno-associated viral vector mediatedMDA7/IL-24 for human pancreatic cancer

2008 - 2010 Development of mouse model and novel gene therapy for Diamond-Blackfan anemia

2008 - 2010 Development of novel bone marrow transplantation for treatment of CNS disorders in lysosomal disease.

2006 - 2007 Molecular mechanism and development of gene therapy for Diamond-Blackfan anemia

2005 - 2007 Non-invasive gene therapy for inherited neurodegenerative disorders (How to cross the BBB?)

2003 - 2004 Gene therapy for rheumatoid arthritis using transduction with angiogenesis inhibitory factor

2002 - 2004 Therapeutic strategies for inherited neurodegerative disorders using gene transfer and stem-cell transplantation technologies

2000 - 2004 HIVベクターの開発

2002 - 2003 血管新生抑制物質による多発性骨髄腫の新規治療法(遺伝子治療)の開発

1997 - 1998 遺伝子治療を目的とた安全でかつ高率な組織特異的遺伝子導入法の開発

1996 - 1997 HIVベクターによる血球系細胞(リンパ球、造血幹細胞)への遺伝子導入

1995 - 1996 GENE TRANSFER INTO NON DIVIDING CELLS BY MEANS OF HIV

1995 - 1996 アデノ随伴ウィルスベクターによる造血幹細胞への遺伝子導入

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Papers (117)：

Tae Matsumoto, Sonoko Narisawa, José Luis Millán, Koichi Miyake. Gene Therapy for Hypophosphatasia: Current Management and Future. Genetically Modified Organisms [Working Title]. 2024
Koichi Miyake. Development of a new gene therapy drug as a treatment for hypophosphatasia. Open Access Government. 2023. 39. 44-45
Koichi Miyake. Development of gene therapy for hypophosphatasia. Impact. 2023. 2023. 59-61
Flavia Amadeu de Oliveira, Fatma F Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan. Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia. JBMR plus. 2023. 7. 1. e10709
Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada. Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A. Scientific reports. 2021. 11. 1. 20513-20513

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MISC (152)：

松本多絵, 趙東威, 三宅紀子, 成澤園子, ミヤン・ホセ, 三宅弘一. 低ホスファターゼ症に対する新規治療薬(遺伝子治療薬:ARU-2801)の有効性と安全性の検討. 日本小児科学会雑誌. 2024. 128. 2. 272-272
三宅弘一. 研究者の最新動向低ホスファターゼ症に対する遺伝子治療. Precision Medicine. 2023. 6. 3. 226-230
三宅弘一. 低ホスファターゼ症に対する新規治療法(遺伝子治療薬)の開発. BIO Clinica. 2023. 38. 1. 87-91
三宅弘一. Development of a novel gene therapy drug (ARU-2801) for Hypophosphatasia. 月刊Precision Medicine. 2022. 5. 10
三宅弘一. Development of gene therapy drug (ARU-2801) for Hypophosphatasia. Bio Clinica. 2022. 37. 6

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Books (5)：

遺伝子治療開発研究ハンドブック
エヌ・ティー・エス 2023 ISBN:9784860438401
Selected Topics in Neonatal Care
InTech 2018
Gene Therapy-Principles and Challenges
InTech 2015
Novel Gene Therapy Approaches
InTech 2013
Viral Gene Therapy
InTech 2011

Lectures and oral presentations (18)：

Direct comparison between single-stranded and self-complementary type 9 AAV vector to treat adult MLD model mice by intravenous injection
(he 24th Annual Meeting of Japan Society of Gene Therapy 2018)
Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of adeno-associated virus vector
(第75回脳神経外科学会学術総会 2016)
Involvement of miR-17-92 cluster in the neuropathic pain and axonal growth.
(第88回日本薬理学会年会 2015)
異染性白質ジストロフィー(MLD)の遺伝子治療基盤研究
(2015)
アデノ随伴ウイルスベクターの脳室内注入による異染性白色ジストロフィーモデルマウスの遺伝子治療
(第20 回 ?本ライソゾーム病研究会 2015)

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Education (2)：

1990 - 1994 Nippon Medical School Graduate School
1982 - 1988 Nippon Medical School Medical School

Professional career (1)：

医学博士 (日本医科大学)

Work history (7)：

2021/02 - 現在 Nippon Medical School Department of Gene Therapy Professor
2007/04 - 2021/01 Nippon Medical School Department of Biochemistry and Molecular Biology Associate Professor
1999/04 - 2007/03 Nippon Medical School Department of Biochemistry and Molecular Biology Associate Professor/Lecturer
2003/02 - 2005/03 Lund university Molecular Medicine and Gene Therapy Research Scientist
1996/05 - 1999/03 Nippon Medical School Department of Biochemistry and Molecular Biology Assistant professor

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Committee career (3)：

- 現在厚生労働省厚生科学審議会遺伝子治療臨床研究に関する審査委員会委員
- 現在大阪大学第二特定認定再生医療等委員会委員
- 現在日本遺伝子細胞治療学会評議員

Awards (4)：

2002 - 日本医科大学助講会High Impact Factor 賞
1997 - 日本医科大学同窓会奨励賞受賞
1993 - 日本医科大学医学会奨学賞受賞
1993 - 日本血液学会研究奨励賞受賞

Association Membership(s) (4)：

American Society of hematology , American Society of Cell and Gene Therapy , 日本遺伝子治療学会 , 日本内科学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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