Masuda Akio

マスダアキオ | Masuda Akio

Homepage URL (1)： http://www.med.nagoya-u.ac.jp/neurogenetics/

Research field (3)： Neuroscience - general , Genomics , Cell biology

Research theme for competitive and other funds (19)：

2021 - 2025 天然変性領域 (IDR) 形成を支えるスプライシング機構から俯瞰する相分離現象
2021 - 2025 FTLDスペクトラムにおける核内RNP複合体の機能変化に基づく核酸医療の開発
2022 - 2024 in situ cDNA増幅による超高感度 RNA-蛋白相互作用解析法の開発
2021 - 2024 液-液相分離を正常化する核酸医薬によるFTLD治療法開発
2020 - 2023 Elucidation of molecular mechanisms of neuromuscular junction formations in physiology and pathology

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Papers (92)：

Akio Masuda, Takaaki Okamoto, Toshihiko Kawachi, Jun-Ichi Takeda, Tomonari Hamaguchi, Kinji Ohno. Blending and separating dynamics of RNA-binding proteins develop architectural splicing networks spreading throughout the nucleus. Molecular cell. 2024
Yuichi Miyairi, Bisei Ohkawara, Ayato Sato, Ryusuke Sawada, Hisao Ishii, Hiroyuki Tomita, Taro Inoue, Hiroaki Nakashima, Mikako Ito, Akio Masuda, et al. A class of chemical compounds enhances clustering of muscle nicotinic acetylcholine receptor in cultured myogenic cells. Biochemical and biophysical research communications. 2024. 731. 150400-150400
Bisei Ohkawara, Hiroyuki Tomita, Taro Inoue, Shaochuan Zhang, Shunsuke Kanbara, Hiroyuki Koshimizu, Yuki Miyasaka, Jun-Ichi Takeda, Hiroshi Nishiwaki, Hiroaki Nakashima, et al. Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024. 21. 2. e00318
Paniz Farshadyeganeh, Mohammad Nazim, Ruchen Zhang, Bisei Ohkawara, Kazuki Nakajima, Mohammad Alinoor Rahman, Farhana Nasrin, Mikako Ito, Jun-Ichi Takeda, Kenji Ohe, et al. Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction. iScience. 2023. 26. 10. 107746-107746
Atefeh Joudaki, Jun-ichi Takeda, Akio Masuda, Rikumo Ode, Koichi Fujiwara, Kinji Ohno. FexSplice: A LightGBM-Based Model for Predicting the Splicing Effect of a Single Nucleotide Variant Affecting the First Nucleotide G of an Exon. Genes. 2023. 14. 9. 1765-1765

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MISC (3)：

Patents (1)：

タンパク質-RNA相互作用の検出

Books (6)：

Detection of RNA-protein interaction sites by tRIP-seq
2022
Liquid-liquid phase separation of transcription factors are sustained by large exons in vertebrates
2022
Detection of RNA modification in low input samples by tRIP-seq
2021
Regulation of mRNA length by FUS
2016
Neurodegeneration-associated RNA-binding protein, FUS, regulates mRNA length
ATLAS of Science 2016

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