Rchr
J-GLOBAL ID：200901098397303517
Update date: Oct. 22, 2024
Kikukawa Takashi
キクカワ タカシ | Kikukawa Takashi
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
https://life.sci.hokudai.ac.jp/fa/staff/kikukawa-takashi
Research field (3)：
Molecular biochemistry
, Pharmaceuticals - analytical and physicochemistry
, Biophysics
Research keywords (7)：
Multidrug resistance protein
, Transient absorption spectroscopy
, Membrane transport
, Membrane protein
, Retinylidene protein
, Bio-Physical Chemistry
, Photo-Biology
Research theme for competitive and other funds (18)：
- 2022 - 2025 過渡現象解析で追求する膜輸送タンパク質の多段階構造変化と輸送素過程の連関
- 2022 - 2024 光エネルギーで駆動される物質回収・放出カプセルのボトムアップ構築
- 2021 - 2024 Elucidation of the molecular mechanism by the albumin-mediated hepatic uptake and new development of the mechanistic model to describe the albumin-mediated phenomenon
- 2021 - 2022 膜輸送タンパク質の光エネルギー共役を基盤とする環境浄化大腸菌の開発
- 2021 - 2022 毒物耐性スクリーニングを用いた膜輸送タンパク質の革新的機能改変
- 2018 - 2021 多彩な基質輸送能力を有する輸送担体を制御する輸送分子機構解明
- 2017 - 2019 光駆動型ナトリウムポンプ:イオン輸送素過程の解明と機能改変の試み
- 2014 - 2016 Elucidation of the molecular valve in the transporter to determine the direction of the transporter cycle
- 2014 - 2016 Study on the physiological significance and the molecular mechanism of Na+-pumping rhodopsin
- 2011 - 2013 Characterization of molecular mechanism of electrogenic transporters accompanying ion movement
- 2011 - 2013 Analysis of the elementary processes in the light-driven Cl- pump of halorhodopsin
- 2008 - 2010 A developmental approach to clarify a molecular mechanism of transporter utilizing a model transporter as a light-driven ion pump
- 2007 - 2009 Molecular mechanisms in light-driven anion pump of halorhodopsin
- 2007 - 2009 Elucidation of Cl--pumping mechanism and significance of trimer formation of halorhodopsin
- 2006 - 2007 A new approach to investigate on electrogenic transporters with Xenopusoocyte expression system
- 2004 - 2006 抗菌薬排出蛋白質の分子機構-細菌の小型排出蛋白質を例として-
- 2004 - 2006 Signal transduction via membrane protein complex : photo-signal transduction of Halobacterium salinarum
- 1998 - 1999 アラメシチンのチャネル形成過程-膜脂質の動的構造変化の解析から-
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Papers (123)：
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Xin Zhang, Hajime Tamaki, Takashi Kikukawa, Toshimichi Fujiwara, Yoh Matsuki. Structural changes of Natronomonas pharaonis halorhodopsin in its late photocycle revealed by solid-state NMR spectroscopy. Biophysical chemistry. 2024. 315. 107329-107329
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Kana Miyazaki, Takashi Kikukawa, Masashi Unno, Tomotsumi Fujisawa. Chromophore Structural Change during the Photocycle of a Light-Driven Cl- Pump from Mastigocladopsis repens: A Cryogenic Raman Study. The journal of physical chemistry. B. 2024. 128. 40. 9692-9698
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Kaori Kondo, Ryouhei Ohtake, Shunsuke Nakano, Mia Terashima, Hisaya Kojima, Manabu Fukui, Makoto Demura, Takashi Kikukawa, Takashi Tsukamoto. Contribution of Proteorhodopsin to Light-Dependent Biological Responses in Hymenobacter nivis P3T Isolated from Red Snow in Antarctica. Biochemistry. 2024. 63. 18. 2257-2265
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Chihaya Hamada, Keisuke Murabe, Takashi Tsukamoto, Takashi Kikukawa. Direct detection of the chloride release and uptake reactions of Natronomonas pharaonis halorhodopsin. The Journal of biological chemistry. 2024. 300. 9. 107712-107712
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Kazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki Tamaoki. A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells. RSC medicinal chemistry. 2024
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MISC (56)：
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GU Hao, 加藤貴純, 石田博昭, 熊木康裕, 塚本卓, 塚本卓, 菊川峰志, 菊川峰志, 出村誠, 出村誠, et al. Overexpression of stable isotope-labeled cecropin P1 by using calmodulin-fusion protein system and NMR researches. Abstracts. Annual Meeting of the NMR Society of Japan. 2020. 59th
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Jun Tamogami, Takashi Kikukawa, Naoki Kamo. Functional significance of interhelical interactions between aspartic acid and cysteine residues in microbial rhodopsin. Atlas of Science (Web). 2019
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高橋浩, 吉野賢, 森田康平, 高木俊之, 横山泰範, 菊川峰志, 網井秀樹, 金森敏幸, 園山正史, 園山正史, et al. 部分フッ素化リン脂質F4-DMPC膜に再構成した膜タンパク質バクテリオロドプシンの2次元格子の安定性. KEK Progress Report (Web). 2019. 2019-7
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川原るい, 高木俊之, 高橋浩, 菊川峰志, 網井秀樹, 園山正史, 園山正史, 園山正史. 擬環状エーテル型脂質のフッ素化が膜物性および膜タンパク質の構造・機能に及ぼす影響. フッ素化学討論会講演要旨集. 2019. 42nd
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平峰里菜, 久米田博之, 久米田博之, 熊木康裕, 菊川峰志, 菊川峰志, 出村誠, 出村誠, 中村公則, 綾部時芳, et al. マウス抗菌ペプチドcryptdin-4の変異体を用いた作用機構の解析. 日本農芸化学会大会講演要旨集(Web). 2017. 2017. ROMBUNNO.4J29a01 (WEB ONLY)
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Books (7)：
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創薬研究のための相互作用解析パーフェクト : 低中分子・抗体創薬におけるスクリーニング戦略と実例、in silico解析、一歩進んだ分析技術まで
羊土社 2021 ISBN:9784758122566
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Epigenetics to Optogenetics - A New Paradigm in the Study of Biology
IntechOpen 2021
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Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond
Springer 2021
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光と生命の事典
朝倉書店 2016 ISBN:4254171617
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Optogenetics: Light-Sensing Proteins and Their Applications
Springer 2015 ISBN:4431555153
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Lectures and oral presentations (11)：
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Retinal conformations in microbial rhodopsins probed by Raman optical activity
(19th International Conference on Retinal Proteins 2022)
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A possible gate-opening mechanism of Indibacter alkaliphilus sodium pump rhodopsin
(19th International Conference on Retinal Proteins 2022)
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Photoreaction analysis of microbial rhodopsin by flash photolysis techniques
(The 58th Annual Meeting of the Biophysical Society of Japan 2020)
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微生物ロドプシンのホモ多量体形成の機能的意義
(東京大学物性研究所ワークショップ「レチナールタンパク質の光機能発現の物理と化学」 2019)
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Cyanobacterial rhodopsin having TSD motif
(8th Asia and Oceania Conference on Photobiology 2017)
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Education (3)：
- 1993 - 1996 Hokkaido University Graduate School of Engineering
- 1991 - 1993 Hokkaido University Graduate School of Engineering
- 1987 - 1991 Hokkaido University School of Engineering Department of Electronics Engineering
Professional career (1)：
Work history (3)：
- 2021/06 - 現在 Faculty of Advanced Life Science, Hokkaido University Associate Professor
- 2013/04 - 2021/05 北海道大学 先端生命科学研究院 講師
- 2011 - 北海道大学 先端生命科学研究院 助教
Committee career (3)：
- 2023/01 - 現在 日本生物物理学会 生物物理編集委員
- 2020/04 - 現在 日本生物物理学会 分野別専門委員
- 1998/08 - 1999/03 北海道立工業試験場 特許情報移転促進委員
Awards (1)：
Association Membership(s) (6)：
American Society for Biochemistry and Molecular Biology
, 日本蛋白質科学会
, 日本生化学会
, 日本生物物理学会
, The Japanease Biochemical Society
, The Biophysical Society of Japan
