Rchr
J-GLOBAL ID：200901099417161567   Update date: Nov. 15, 2024

Kanai Motomu

カナイ モトム | Kanai Motomu
Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences

About The University of Tokyo Graduate School of Pharmaceutical Sciences


Job title： Professor
Homepage URL  (1)： http://www.f.u-tokyo.ac.jp/~kanai/index.html
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (2)： 有機化学 ,  Organic Chemistry
Research theme for competitive and other funds  (44)：
  • 2023 - 2027 Elucidation of the role of autophagy in photo-oxygenated amyloid degradation
  • 2021 - 2024 Chemical glycan modification of membrane proteins for "manipulating" membrane dynamics
  • 2020 - 2024 生体分子の構造変換ダイナミズムに介入する化学触媒研究
  • 2022 - 2023 分子合成オンデマンドを実現するハイブリッド触媒系の創製
  • 2020 - 2023 超高性能クライオEMの分子プローブ創製
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Papers (226)：
  • Tomoyuki Fukuta, Toshifumi Tatsumi, Kohei Fujiyoshi, Takashi Koyama, Shigehiro A Kawashima, Harunobu Mitsunuma, Kenzo Yamatsugu, Motomu Kanai. Umpolung Phosphorylation of Tyrosine via 1,2-Phospha-Brook Rearrangement. Organic letters. 2024. 26. 41. 8827-8831
  • Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, et al. Chemical catalyst manipulating cancer epigenome and transcription. 2024
  • Tamiko Nozaki, Mayu Onoda, Misuzu Habazaki, Yuma Takeuchi, Hisashi Ishida, Yuko Sato, Tomoya Kujirai, Kayo Hanada, Kenzo Yamatsugu, Hitoshi Kurumizaka, et al. Logics for Developing Regioselective Histone Acetylating Catalysts. 2024
  • Hiroki Umeda, Kayo Suda, Daisuke Yokogawa, Yuto Azumaya, Nobuo Kitada, Shojiro A Maki, Shigehiro A Kawashima, Harunobu Mitsunuma, Yuki Yamanashi, Motomu Kanai. Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids. Angewandte Chemie (International ed. in English). 2024. e202405605
  • Toshifumi Tatsumi, Songji Zhao, Akitomo Kasahara, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Tatsuhiko Kodama, Kazuhiro Takahashi, Akira Sugiyama, Kohshin Washiyama, et al. In vivo-stable bis-iminobiotin for targeted radionuclide delivery with the mutant streptavidin. Bioorganic & Medicinal Chemistry Letters. 2024. 129803-129803
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MISC (316)：
  • 福田智之, 藤吉浩平, 川島茂裕, 三ツ沼治信, 三ツ沼治信, 山次健三, 金井求. Umpolung phosphorylation of tyrosine toward protein/peptide modification. 日本薬学会年会要旨集(Web). 2024. 144th
  • 山根三奈, 梅田大輝, 豊邉萌, 岩井篤志, 工藤玄己, 三ツ沼治信, 三ツ沼治信, 堀由起子, 富田泰輔, 岡田匡充, et al. Small Molecule Catalysts Function as Amyloid Breakers in vivo via Photooxygenation of Transthyretin Amyloids. 日本薬学会年会要旨集(Web). 2024. 144th
  • 有井優, CHEN Hongyu, 三ツ沼治信, 三ツ沼治信, 金井求. Catalytic Allylation of Ketones Using Unactivated Alkenes. 日本化学会春季年会講演予稿集(Web). 2024. 104th
  • 井上丈司, 山次健三, 三ツ沼治信, 三ツ沼治信, 金井求. Development of catalytic chemo-selective decarboxylation of aspartic acid. 日本化学会春季年会講演予稿集(Web). 2024. 104th
  • 金井求, 生長幸之助, 豊邉萌. レドックス活性を利用した抗体修飾と応用. MEDCHEM NEWS. 2023. 33. 1. 33-37
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Patents (2)：
  • 配位子及びそれを用いた不斉触媒
  • Chiral Ligands and Enantioselective Catalysts
Education (4)：
  • - 1995 Osaka University
  • - 1995 Osaka University Graduate School, Division of Natural Science
  • - 1989 The University of Tokyo Faculty of Pharmaceutical Sciences
  • - 1989 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (2)：
  • (BLANK)
  • (BLANK)
Work history (9)：
  • 2010/04 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2003 - 2010/03 - 同助教授
  • 2000 - 2003 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2000 - 2003 Grad. School. of Pharm. Sci. The Univ. of Tokyo. Lecturer
  • 2003 - - sssociate professor
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Awards (9)：
  • 2022/07 - 産経新聞社 独創性を拓く 先端技術大賞 社会人部門 特別賞 アミロイド選択的光酸素化技術によるアミロイド病態治療 ~アルツハイマー病、さらにはアミロイドーシスの根本治療法開発を目指して~
  • 2022/03 - Nagoya Silver Medal
  • 2016 - トムソン・ロイター第4回リサーチフロントアワード
  • 2011 - Novartis Lecturer in Organic Chemistry (2011年)
  • 2005 - Merck-Banyu Lectureship Award
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Association Membership(s) (4)：
アメリカ化学会 ,  有機合成化学協会 ,  日本化学会 ,  日本薬学会
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