Art

J-GLOBAL ID：200902012104548830   Reference number：92A0512293

2-Carboxytetrahydroquinolines. Conformational and Stereochemical Requirements for Antagonism of the Glycine Site on the NMDA Receptor.

2-カルボキシテトラヒドロキノリン類 NMDA受容器上のグリシン部位のきっ抗薬としてのコンフォメーション的および構造的必要条件

Author (8)： CARLING R W (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  LEESON P D (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  MOSELEY A M (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  BAKER R (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  FOSTER A C (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  GRIMWOOD S (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  KEMP J A (Merck Sharp and Dohme Research Lab., Essex, GBR) ,  MARSHALL G (Merck Sharp and Dohme Research Lab., Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 35  Issue： 11  Page： 1942-1953  Publication year： May. 29, 1992 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： ketone ,...
Semi thesaurus term： メチルアスパラギン酸受容器 ,...

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JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (40)： Transtorine ,  5-Chloro-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  Ageloline A ,  DCKA ,  5,7-Dimethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dibromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  5-Chloro-7-iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  7-Chloro-5-iodo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ,  1,2,3,4-Tetrahydro-4-oxo-2-quinolinecarboxylic acid ,  5-Chloro-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  7-Chloro-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dichloro-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dimethyl-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  5,7-Dibromo-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  5-Chloro-7-iodo-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  7-Chloro-5-iodo-1,2,3,4-tetrahydro-4-oxoquinoline-2-carboxylic acid ,  (2R)-1,2,3,4-Tetrahydro-3β,5,7-trimethyl-4-oxoquinoline-2β-carboxylic acid ,  (2R)-1,2,3,4-Tetrahydro-3α,5,7-trimethyl-4-oxoquinoline-2β-carboxylic acid ,  5,7-Dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ,  (2S)-5-Chloro-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid 4-methyl ester ,  (2S)-7-Chloro-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid 4-methyl ester ,  (2S)-5,7-Dichloro-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid 4-methyl ester ,  (2S)-5,7-Dibromo-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid 4-methyl ester ,  (2S)-7-Chloro-5-iodo-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid 4-methyl ester ,  (2R)-5-Chloro-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid 4-methyl ester ,  (2R)-7-Chloro-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid 4-methyl ester ,  (2R)-5,7-Dichloro-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid 4-methyl ester ,  (2R)-5,7-Dibromo-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid 4-methyl ester ,  (2R)-7-Chloro-5-iodo-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid 4-methyl ester ,  (2S)-5,7-Dichloro-1,2,3,4-tetrahydroquinoline-2α,4α-dicarboxylic acid ,  (2R)-5,7-Dichloro-1,2,3,4-tetrahydroquinoline-2β,4α-dicarboxylic acid ,  5,7-Dichloroquinoline-2,4-dicarboxylic acid ,  (2S)-5,7-Dichloro-1,2,3,4-tetrahydro-4α-(phenylacetyl)quinoline-2α-carboxylic acid ,  (2R)-5,7-Dichloro-1,2,3,4-tetrahydro-4α-(phenylacetyl)quinoline-2β-carboxylic acid ,  (2S)-5,7-Dichloro-1,2,3,4-tetrahydro-4α-aminocarbonylquinoline-2α-carboxylic acid ,  (2R)-5,7-Dichloro-1,2,3,4-tetrahydro-4α-aminocarbonylquinoline-2β-carboxylic acid ,  (2R)-5,7-Dichloro-1,2,3,4-tetrahydro-4α-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]quinoline-2β-carboxylic acid ,  (2R)-2β-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroquinoline-4α-acetic acid 4-methyl ester ,  (2R)-2β-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroquinoline-4α-acetic acid ,  (2S)-2α-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroquinoline-4α-acetic acid

Terms in the title (6)： NMDA ,  受容器 ,  グリシン ,  きっ抗薬 ,  コンフォメーション ,  必要条件