Art

J-GLOBAL ID：200902137714109151   Reference number：98A0176970

Madindolines, Novel Inhibitors of IL-6 Activity from Streptomyces sp. K93-0711. II. Physico-chemical Properties and Structural Elucidation.

マジンドリン類,Streptomyces sp.K93-0711由来物質で,IL-6活性の新規抑制剤 II 物理化学的性質と構造解析

Author (7)： TAKAMATSU S (Kitasato Univ., Tokyo, JPN) ,  KIM Y-P (Kitasato Univ., Tokyo, JPN) ,  ENOMOTO A (Kitasato Univ., Tokyo, JPN) ,  HAYASHI M (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  KOMIYAMA K (Kitasato Univ., Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 50  Issue： 12  Page： 1069-1072  Publication year： Dec. 1997 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antibiotics ,...
Semi thesaurus term： Streptomyces ,...

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JST classification (1)： Antibiotics in general  (GX01000E)

Substance index (1)： (+)-Madindoline A

Reference (10)：

• 1) YAMASAKI, K.; T. TAGA, Y. HIRATA, H. YAWATA, Y. KAWANISHI, B. BED, T. TANIGUCHI, T. HIRANO & T. KISHIMOTO: Cloning and expression of the human interleukin-6 (BSF-2/IFNβ) receptor. Science 241: 825-828, 1988
• 2) STRASSMANN, G.; M. FOMG, J. S. KENNEY & C. O. JACOB: Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J. Clin. Invest. 89: 1681-1684, 1992
• 5) SODA, K.; M. KAWAKAMI, A. KASHII & M. MIYATA: Characterization of mice bearing subclones of colon 26 adenocarcinoma disqualifies interleukin-6 as the sole inducer of cachexia. Jpn. J. Cancer Res. 85: 1124-1130, 1994
• 6) HAYASHI, M.; Y.-P. KIM, S. TAKAMATSU, T. KOMIYA, R. MASUMA, S. PREEPRAME, K. KOMIYAMA, H. TANAKA & S. OMURA: Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiotics 49: 631-634,1996
• 7) TAKAMATSU, S.; Y.-P. KIM, T. KOMIYA, T. SUNAZUKA, M. HAYASHI, H. TANAKA, K. KOMIYAMA & S. OMURA: Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation. J. Antibiotics 49: 635 - 683, 1996

Terms in the title (8)： マジンドリン ,  Streptomyces ,  物質 ,  IL-6 ,  活性 ,  抑制剤 ,  物理化学的性質 ,  構造解析