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J-GLOBAL ID：200902231283313127   Reference number：03A0344430

Decreased Tumorigenicity In Vivo When Transforming Growth Factor β Treatment Causes Cancer Cell Senescence

形質転換成長因子ベータ処理が癌細胞の老化を引き起こしたときのin vivoにおける腫ようの減少

Author (7)： KATAKURA Y (Kyushu Univ., Fukuoka, JPN) ,  NAKATA E (Kyushu Univ., Fukuoka, JPN) ,  TABIRA Y (Kyushu Univ., Fukuoka, JPN) ,  MIURA T (Kyushu Univ., Fukuoka, JPN) ,  TERUYA K (Kyushu Univ., Fukuoka, JPN) ,  TSUCHIYA T (National Inst. Health Sci., Tokyo, JPN) ,  SHIRAHATA S (Kyushu Univ., Fukuoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 67  Issue： 4  Page： 815-821  Publication year： Apr. 23, 2003 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *TGF beta ,...

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JST classification (1)： Cell physiology in general  (EF02010S)

Reference (23)：

• 1) Campisi, J., Cancer, aging and cellular senescence. In Vivo, 14, 183-188 (2000).
• 2) Smith, J. R., and Pereira-Smith, O. M., Replicative senescence: implications for in vivo aging and tumor suppression. Science, 273, 63-67 (1996).
• 3) Young, J. I., and Smith, J. R., DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle withdrawal. J. Biol. Chem., 276, 19610-19616 (2001).
• 4) Dimri, G. P., Itahana, K., Acosta, M., and Campisi, J., Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell. Biol., 20, 273-285 (2000).
• 5) Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W., Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16^INK4a. Cell, 88, 593-602 (1997).

Terms in the title (4)： 形質転換成長因子ベータ ,  癌細胞 ,  老化 ,  腫よう