Art

J-GLOBAL ID：200902243567775560   Reference number：03A0454618

Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells

ヒト慢性骨髄性白血病K562細胞におけるSTI-571に対する耐性の復帰

Author (9)： MUKAI M (Kagoshima Univ., Kagoshima) ,  CHE X-F (Kagoshima Univ., Kagoshima) ,  FURUKAWA T (Kagoshima Univ., Kagoshima) ,  SUMIZAWA T (Kagoshima Univ., Kagoshima) ,  AOKI S (Osaka Univ., Osaka) ,  REN X-Q (Kagoshima Univ., Kagoshima) ,  HARAGUCHI M (Kagoshima Univ., Kagoshima) ,  SUGIMOTA Y (Japanese Foundation for Cancer Res., Tokyo) ,  KOBAYASHI M (Osaka Univ., Osaka)
Material： Cancer Science  (Cancer Sci)
Volume： 94  Issue： 6  Page： 557-563  Publication year： Jun. 30, 2003 
JST Material Number： F0633A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： bridged compound ,...

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JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Substance index (3)： STI-571 ,  Vincristine ,  Cepharanthine

Reference (35)：

• MELO, JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood. 1996, 88, 2375-2384
• RAITANO, AB. Signal transduction by wild-type and leukemogenic Abl proteins. Biochim Biophys Acta. 1997, 1333, F201-F216
• SKORSKA, NM. Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL is dependent on intact Src homology (SH) 3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med. 1999, 189, 1229-1242
• DEININGER, MW. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood. 1997, 90, 3691-3698
• MAHON, FX. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571 : diverse mechanisms of resistance. Blood. 2000, 96, 1070-1079

Terms in the title (6)： ヒト ,  慢性骨髄性白血病 ,  K562細胞 ,  STI-571 ,  耐性 ,  復帰