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J-GLOBAL ID：200902250296659957   Reference number：06A0416944

Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-Induced Osteoclast Differentiation

アスパラギン酸プロテイナーゼ阻害剤ペプスタチンAはRANKL誘導破骨細胞分化を抑制する

Author (11)： YOSHIDA Hajime (Nagasaki Univ., Nagasaki) ,  OKAMOTO Kuniaki (Nagasaki Univ., Nagasaki) ,  IWAMOTO Tsutomu (Nagasaki Univ., Nagasaki) ,  SAKAI Eiko (Nagasaki Univ., Nagasaki) ,  KANAOKA Kazuhiro (Nagasaki Univ., Nagasaki) ,  HU Jin-Ping (Nagasaki Univ., Nagasaki) ,  SHIBATA Mitsue (Nagasaki Univ., Nagasaki) ,  HOTOKEZAKA Hitoshi (Nagasaki Univ., Nagasaki) ,  NISHISHITA Kazuhisa (Nagasaki Univ., Nagasaki) ,  MIZUNO Akio (Nagasaki Univ., Nagasaki) ,  KATO Yuzo (Nagasaki Univ., Nagasaki)
Material： Journal of Biochemistry  (J Biochem)
Volume： 139  Issue： 3  Page： 583-590  Publication year： Mar. 01, 2006 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *proteinase inhibitor ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (3)： Enzyme in general  (EB09010D) ,  Skeletal system  (EJ10030R) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Pepstatin A

Reference (44)：

• LACEY, D. L. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998, 93, 165-176
• FULLER, K. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J. Exp. Med. 1998, 188, 997-1001
• KONG, Y-Y. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999, 397, 315-323
• HSU, H. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. 1999, 96, 3540-3545
• BURGESS, T. L. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J. Cell Biol. 1999, 145, 527-538

Terms in the title (6)： アスパラギン酸プロテイナーゼ ,  阻害剤 ,  ペプスタチンA ,  RANKL ,  誘導 ,  破骨細胞分化