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J-GLOBAL ID：200902251679058414   Reference number：07A0629503

Construction of Human Fab (γ1/κ) Library and Identification of Human Monoclonal Fab Possessing Neutralizing Potency against Japanese Encephalitis Virus

ヒトFab(γ1/κ)ライブラリーの構築と日本脳炎ウイルスへの中和力を有するヒトモノクローナルFabの同定

Author (7)： ARAKAWA Mitsue (Dep. of Infectious Diseases, Fac. of Medicine, Oita Univ.) ,  YAMASHIRO Tetsu (Center for International Collaborative Res., Nagasaki Univ.) ,  YAMASHIRO Tetsu (Inst. of Tropical Medicine, Nagasaki Univ.) ,  UECHI Gen-ichiro (Center for International Collaborative Res., Nagasaki Univ.) ,  UECHI Gen-ichiro (Inst. of Tropical Medicine, Nagasaki Univ.) ,  TADANO Masayuki (Div. of Molecular Virology, Dep. of Microbiology, Graduate School of Medicine Univ. of the Ryukyus) ,  NISHIZONO Akira (Dep. of Infectious Diseases, Fac. of Medicine, Oita Univ.)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 51  Issue： 6  Page： 617-625 (J-STAGE)  Publication year： 2007 
JST Material Number： F0715A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： monoclonal antibody ,...
Semi thesaurus term： serodiagnosis ,...

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JST classification (2)： Antigens,antibodies,complements in general  (ED04010A) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Reference (29)：

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• ANDO, T. Construction of human Fab library and isolation of monoclonal Fabs with rabies virus-neutralizing ability. Microbiol. Immunol. 2005, 49, 311-322
• ANDRIS-WIDHOPF, J. Generation of antibody libraries : PCR amplification and assembly of light- and heavy-chain coding sequences. Phage display-a laboratory manual-. 2001, 9.1-9.113
• BAKKER, A. B. Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants. J. Virol. 2005, 79, 9062-9068
• BRENSING-KUPPERS, J. The human immunoglobulin kappa locus on yeast artificial chromosomes (YACs). Gene. 1997, 191, 173-181

Terms in the title (6)： ヒト ,  ライブラリー ,  構築 ,  日本脳炎ウイルス ,  中和 ,  同定