Art

J-GLOBAL ID：200902269759224214   Reference number：09A0155323

Design, synthesis, and evaluation of a novel bridged nucleic acid, 2′,5′-BNA^ON, with S-type sugar conformation fixed by N-O linkage

N-O結合により固定化されたS型糖配座の新規な架橋核酸,2′,5′-BNA^ON,の設計,合成,および評価

Author (7)： KODAMA Tetsuya (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  MATSUO Chieko (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  ORI Hidetsugu (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  MIYOSHI Tetsuya (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  OBIKA Satoshi (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  MIYASHITA Kazuyuki (Fac. of Pharmacy, Osaka Ohtani Univ., 3-11-1 Nishikiori-kita, Tondabayashi, Osaka 584-8540, JPN) ,  IMANISHI Takeshi (Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 65  Issue： 10  Page： 2116-2123  Publication year： Mar. 07, 2009 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *nucleoside analog ,  *bridged compound ,  molecular design ,  asymmetric synthesis ,  functional group protection ,  deprotection ,  coupling reaction ,  *oligonucleotide ,  solid phase synthesis ,  DNA ,  double stranded RNA ,  double strand DNA

JST classification (2)： Nucleosides,nucleotides  (CF10060K) ,  Nucleic acids in general  (EB04010U)

Substance index (11)： 3-(Benzyloxymethyl)-3′-O,5′-O-[oxybis(diisopropylsilanediyl)]uridine ,  2′-O-Mesyl-3-(benzyloxymethyl)uridine ,  2′-O-Mesyl-3-(benzyloxymethyl)-3′-O-(tert-butyldiphenylsilyl)-5′-(hydroxyamino)-5′-deoxyuridine ,  (4aβ)-2-(Benzyloxymethyl)-8β-(tert-butyldiphenylsiloxy)-5,9α:7α,10α-diepoxydecahydro-1H-2,5,10a-triazabenzocyclooctene-1,3-dione ,  (1α,5α,8R)-7β-[2,4-Dioxo-3-(benzyloxymethyl)-1,2,3,4-tetrahydropyrimidine-1-yl]-8-(tert-butyldiphenylsiloxy)-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-carboxylic acid 4-nitrophenyl ester ,  3-(Benzyloxymethyl)-3′-O-[[(1α,5α,8R)-7β-[2,4-dioxo-3-(benzyloxymethyl)-1,2,3,4-tetrahydropyrimidine-1-yl]-8-(tert-butyldiphenylsiloxy)-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]-5′-O-(4,4′-dimethoxytrityl)thymidine ,  3′-O-[[(1α,5α,8R)-7β-[2,4-Dioxo-3-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-1-yl]-8-(tert-butyldiphenylsiloxy)-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]thymidine ,  3-(Hydroxymethyl)-3′-O-[[(1α,5α,8R)-7β-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)-8-(tert-butyldiphenylsiloxy)-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]thymidine ,  3-(Hydroxymethyl)-3′-O-[[(1α,5α,8R)-7β-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)-8-(tert-butyldiphenylsiloxy)-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]-5′-O-(4,4′-dimethoxytrityl)thymidine ,  3-(Hydroxymethyl)-3′-O-[[(1α,5α,8R)-7β-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)-8-hydroxy-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]-5′-O-(4,4′-dimethoxytrityl)thymidine ,  3-(Hydroxymethyl)-3′-O-[[(1α,5α,8R)-7β-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-yl)-8-[2-cyanoethoxy(diisopropylamino)phosphino]-2,6-dioxa-3-azabicyclo[3.2.1]octane-3-yl]carbonyl]-5′-O-(4,4′-dimethoxytrityl)thymidine

Terms in the title (6)： N-O結合 ,  配座 ,  架橋 ,  核酸 ,  設計 ,  評価