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J-GLOBAL ID：200902277481634630   Reference number：04A0664805

Erinacol (Cyatha-3,12-dien-14β-ol) and 11-O-Acetylcyathin A₃, New Cyathane Metabolites from an Erinacine Q-Producing Hericium erinaceum

エリナコール(シアタ-3,12-ジエン-14β-オール)および11-O-Acetylcyathin A₃ エリナシンQ生産Hericium erinaceum由来の新しいCyathane代謝産物

Author (5)： KENMOKU H (Iwate Univ., Tsuruoka, JPN) ,  TANAKA K (Yamagata Univ., Tsuruoka, JPN) ,  OKADA K (Yamagata Univ., Yamagata, JPN) ,  KATO N (Osaka Univ., Ibaraki, JPN) ,  SASSA T (Iwate Univ., Tsuruoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 8  Page： 1786-1789  Publication year： Aug. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： biosynthesis ,...
Semi thesaurus term： *Hymenomycetes ,...

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JST classification (2)： Microbial metabolite production  (FK03020A) ,  Microorganism biochemistry  (EG03020N)

Substance index (5)： Nigernin B ,  Erinacol ,  Erinacine Q ,  (3aR)-1-Isopropyl-3aβ,5aα-dimethyl-8-(hydroxymethyl)-9α-acetoxy-2,3,3a,4,5,5a,6,9,10,10aβ-decahydrocyclohepta[e]indene-6-one ,  (3aR)-1-Isopropyl-3aβ,5aα-dimethyl-8-(hydroxymethyl)-9α-acetoxy-2,3,3a,4,5,5a,6,9,10,10aβ-decahydrocyclohepta[e]indene-6β-ol

Reference (10)：

• 1) Kawagishi, H., Shimada, A., Shirai, R., Okamoto, K., Ojima, F., Sakamoto, H., Isiguro, Y., and Furukawa, S., Erinacines A, B, and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett., 35, 1569–1572 (1994).
• 2) Saito, T., Aoki, F., Hirai, H., Inagaki, T., Matsunaga, Y., Sakakibara, T., Sakemi, S., Suzuki, Y., Watanabe, S., Suga, O., Sujaku, T., Smogowicz, A. A., Truesdell, S. J., Wong, J. W., Nagahisa, A., Kojima, Y., and Kojima, N., Erinacine E as a kappa opioid receptor agonist and its new analogs from basidiomycete, Hericium ramosum. J. Antibiot., 51, 983–990 (1998).
• 3) Kenmoku, H., Sassa, T., and Kato, N., Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic convrsion into erinacines A and B. Tetrahedron Lett., 41, 4389–4393 (2000).
• 4) Kenmoku, H., Shimai, T., Toyomasu, T., Kato, N., and Sassa, T., Erinacine Q, a new erinacine from Hericium erinaceum and its biosynthetic route to erinacine C in the basidiomycete. Biosci. Biotechnol. Biochem., 66, 571–575 (2002).
• 5) Kenmoku, H., Kato, N., Shimada, M., Omoto, M., Mori, A., Mitsuhashi, W., and Sassa, T., Isolation of (−)-cyatha-3,12-diene, common biosynthetic intermediate of cyathane diterpenoids, from Hericium erinaceum, and its formation in a cell-free system. Tetrahedron Lett., 42, 7439–7442 (2001).

Terms in the title (7)： エリナ ,  コール ,  シアタ ,  ジエン ,  エリナシンQ ,  Hericium ,  代謝産物