Art

J-GLOBAL ID：200902287203473787   Reference number：07A0844553

Diphtheria Toxin Mutant CRM197 Possesses Weak EF2-ADP-ribosyl Activity that Potentiates its Anti-tumorigenic Activity

ジフテリア毒素変異体CRM197はそれの抗腫よう形成活性を増強する弱いEF2-ADPリボシル活性を保持する

Author (6)： KAGEYAMA Takuya (Osaka Univ., Osaka) ,  OHISHI Minako (Osaka Univ., Osaka) ,  MIYAMOTO Shingo (Fukuoka Univ., Fukuoka, JPN) ,  MIZUSHIMA Hiroto (Osaka Univ., Osaka) ,  IWAMOTO Ryo (Osaka Univ., Osaka) ,  MEKADA Eisuke (Osaka Univ., Osaka)
Material： Journal of Biochemistry  (J Biochem)
Volume： 142  Issue： 1  Page： 95-104  Publication year： Jul. 01, 2007 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Diphtheria Toxin ,...
Semi thesaurus term： tumorigenesis ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=07A0844553&from=J-GLOBAL&jstjournalNo=F0286A") }}

JST classification (2)： Toxicity of microorganism derived substances  (GZ03030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Reference (67)：

• COLLIER, R. J. Diphtheria toxin : mode of action and structure. Bacteriol. Rev. 1975, 39, 54-85
• PAPPENHEIMER, A. M. J. Diphtheria toxin. Annu. Rev. Biochem. 1977, 46, 69-94
• CHOE, S. The crystal structure of diphtheria toxin. Nature. 1992, 357, 216-222
• MEKADA, E. Identification of diphtheria toxin receptor and a nonproteinous diphtheria toxin-binding molecule in Vero cell membrane. J. Cell Biol. 1988, 107, 511-519
• UCHIDA, T. Reassembled HVJ (Sendai virus) envelopes containing non-toxic mutant proteins of diphtheria toxin show toxicity to mouse L cell. Nature. 1977, 266, 839-840

Terms in the title (9)： ジフテリア毒素 ,  変異体 ,  CRM197 ,  抗腫よう形成 ,  活性 ,  増強 ,  EF2 ,  ADP ,  リボシル