Art

J-GLOBAL ID：200902290181249331   Reference number：03A0386619

Synthesis and Evaluation of Guanidine-Containing Schiff Base Copper(II), Zinc(II), and Iron(III) Chelates as Trypsin Inhibitors

トリプシン阻害剤としてのグアニジン含有Schiff塩基銅(II),亜鉛(II)及び鉄(III)キレート類の合成及び評価

Author (4)： TOYOTA E (Health Sci. Univ. Hokkaido, Hokkaido, JPN) ,  SEKIZAKI H (Health Sci. Univ. Hokkaido, Hokkaido, JPN) ,  ITOH K (Health Sci. Univ. Hokkaido, Hokkaido, JPN) ,  TANIZAWA K (Health Sci. Univ. Hokkaido, Hokkaido, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 51  Issue： 6  Page： 625-629  Publication year： Jun. 01, 2003 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *copper complex ,...
Semi thesaurus term： Schiff base

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JST classification (2)： Complexes of 9 and 10 groups  (CE01050Y) ,  Synthesis of drugs  (GV01030F)

Substance index (32)： 2-Hydroxy-5-aminobenzaldehyde ,  2-(1,3-Dioxolane-2-yl)-4-nitrophenol ,  2-(1,3-Dioxolane-2-yl)-4-aminophenol ,  2-(1,3-Dioxolane-2-yl)-4-[2,3-bis(benzyloxycarbonyl)guanidino]phenol ,  2-(1,3-Dioxolane-2-yl)-4-guanidinophenol ,  2-Hydroxy-5-guanidinobenzaldehyde ,  N-(2-Hydroxy-5-guanidinobenzylidene)glycine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-alanine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-valine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-leucine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-isoleucine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-phenylalanine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-methionine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-serine ,  N-(2-Hydroxy-5-guanidinobenzylidene)-L-threonine ,  N-(2-Hydroxy-5-amidinobenzylidene)glycine ,  m-Amidinosalicylidene-L-Alanine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-valine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-leucine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-isoleucine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-phenylalanine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-methionine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-serine ,  N-(2-Hydroxy-5-amidinobenzylidene)-L-threonine ,  Glycine ,  Alanine ,  Leucine ,  Isoleucine ,  Phenylalanine ,  Methionine ,  Serine ,  Threonine

Reference (42)：

• 1) Mares-Guia M., Shaw E., J. Biol. Chem., 240, 1579—1585 (1965).
• 2) Mares-Guia M., Shaw E., Cohen W., J. Biol. Chem., 242, 5777—5781 (1967).
• 3) Mares-Guia M., Shaw E., J. Biol. Chem., 242, 5782—5788 (1967).
• 4) Tamura Y., Hirado M., Okamura K., Minato Y., Fujii S., Biochim. Biophys. Acta, 484, 417—422 (1977).
• 5) Tidwell R. R., Geratz J. D., J. Med. Chem., 21, 613—623 (1978).

Terms in the title (8)： トリプシン阻害剤 ,  グアニジン ,  Schiff塩基 ,  銅 ,  亜鉛 ,  鉄 ,  キレート ,  評価