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J-GLOBAL ID：200902291419538066   Reference number：04A0415014

Optimized Conditions for the Enzymatic Hydrolysis of α-Hydroxytriazolam-Glucuronide in Human Urine

人間尿中α-ヒドロキシトリアゾラム-グルクロナイドの酵素加水分解の最適条件

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Author (7)： TSUJIKAWA K (National Res. Inst. of Police Sci., Chiba, JPN) ,  KUWAYAMA K (National Res. Inst. of Police Sci., Chiba, JPN) ,  KANAMORI T (National Res. Inst. of Police Sci., Chiba, JPN) ,  IWATA Y (National Res. Inst. of Police Sci., Chiba, JPN) ,  OHMAE Y (National Res. Inst. of Police Sci., Chiba, JPN) ,  INOUE H (National Res. Inst. of Police Sci., Chiba, JPN) ,  KISHI T (National Res. Inst. of Police Sci., Chiba, JPN)
Material： Journal of Health Science  (J Health Sci)
Volume： 50  Issue： 3  Page： 286-289  Publication year： Jun. 01, 2004 
JST Material Number： S0030A  ISSN： 1344-9702  CODEN： JHSCFD  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Urine ,...

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JST classification (2)： Urine  (EJ09020M) ,  Solvolysis  (CF02040X)

Substance index (3)： α-Hydroxytriazolam ,  Hexane ,  Methylene chloride

Reference (8)：

• 1) Eberts, F. S., Jr., Philopoulos, Y., Reineke, L. M. and Vliek, R. W. (1981) Triazolam disposition. Clin. Pharmacol. Ther., 29, 81-93.
• 2) Hackett, L. P., Dusci, L. J., Ilett, K. F. and Chiswell, G. M. (2002) Optimizing the hydrolysis of codeine and morphine glucuronides in urine. Ther. Drug Monit., 24, 652-657.
• 3) Maurer, H. and Pfleger, K. (1987) Identification and differentiation of benzodiazepines and their metabolites in urine by computerized gas chromatography-mass spectrometry. J. Chromatogr., 422, 85-101.
• 4) Borrey, D., Meyer, E., Lambert, W., Peteghem, C. V. and Leenheer, A. P. D. (2001) Simultaneous determination of fifteen low-dosed benzodiazepines in human urine by solid-phase extraction and gas chromatography-mass spectrometry. J. Chromatogr. B, 765, 187-197.
• 5) Meatherall, R. (1994) Optimal enzymatic hydrolysis of urinary benzodiazepine conjugates. J. Anal. Toxicol., 18, 382-384.

Terms in the title (6)： 人間 ,  尿 ,  α-ヒドロキシトリアゾラム ,  グルクロナイド ,  酵素加水分解 ,  最適条件