Art

J-GLOBAL ID：201002228157380080   Reference number：10A0724951

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture

NLRP3インフラマソーム媒介IL-1β産生,ROS産生およびエンドソーム破裂に対する非晶質シリカ粒子の表面改質の影響

Author (19)： MORISHIGE Tomohiro (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  YOSHIOKA Yasuo (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  YOSHIOKA Yasuo (The Center for Advanced Medical Engineering and Informatics, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  YOSHIOKA Yasuo (Lab. of Pharmaceutical Proteomics, National Inst. of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka ...) ,  INAKURA Hiroshi (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  TANABE Aya (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  YAO Xinglei (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  NARIMATSU Shogo (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  MONOBE Youko (Lab. of Common Apparatus, Div. of Biomedical Res., National Inst. of Biomedical Innovation, 7-6-8 Saito-Asagi ...) ,  IMAZAWA Takayoshi (Lab. of Common Apparatus, Div. of Biomedical Res., National Inst. of Biomedical Innovation, 7-6-8 Saito-Asagi ...) ,  TSUNODA Shin-ichi (The Center for Advanced Medical Engineering and Informatics, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  TSUNODA Shin-ichi (Lab. of Pharmaceutical Proteomics, National Inst. of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka ...) ,  TSUTSUMI Yasuo (The Center for Advanced Medical Engineering and Informatics, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN) ,  TSUTSUMI Yasuo (Lab. of Pharmaceutical Proteomics, National Inst. of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka ...) ,  TSUTSUMI Yasuo (Lab. of Toxicology and Safety Sci., Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka, Suita ...) ,  MUKAI Yohei (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  OKADA Naoki (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  NAKAGAWA Shinsaku (Lab. of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ., 1-6 Yamadaoka ...) ,  NAKAGAWA Shinsaku (The Center for Advanced Medical Engineering and Informatics, Osaka Univ., 1-6 Yamadaoka, Suita, Osaka 565-0871, JPN)
Material： Biomaterials
Volume： 31  Issue： 26  Page： 6833-6842  Publication year： Sep. 2010 
JST Material Number： C0964B  ISSN： 0142-9612  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： medical material ,  *surface modification ,  amorphous state ,  protein complex ,  interleukin 1 ,  active oxygen ,  Endosomes ,  Inflammation ,  macrophage ,  nano particle ,  *silicon dioxide ,  Interleukin-1beta ,  Inflammasomes ,  membrane and film ,  biomembrane ,  Endomembrane system ,  Vesicles
Semi thesaurus term： *silica ,  *非晶質シリカ粒子

JST classification (1)： Medical materials  (GA05040H)

Terms in the title (8)： NLRP3インフラマソーム ,  IL-1β ,  ROS ,  エンドソーム ,  破裂 ,  非晶質 ,  シリカ粒子 ,  表面改質