Art
J-GLOBAL ID：201002245227339166
Reference number：10A0444438
Activated protein C resistance in the Japanese population due to homozygosity for the factor V R2 haplotype
第V因子R2ハプロタイプのホモ接合による日本人集団の活性化蛋白質C抵抗性
Author (7)：
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Material：
Volume：
91
Issue：
3
Page：
549-550
Publication year：
Apr. 2010
JST Material Number：
F0888A
ISSN：
0925-5710
CODEN：
IJHEEY
Document type：
Article
Article type：
短報
Country of issue：
Germany, Federal Republic of (DEU)
Language：
ENGLISH (EN)
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Thesaurus term/Semi thesaurus term
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JST classification (2)：
JST classification
Category name(code) classified by JST.
Basic hematology
, Genetic variation
Reference (8)：
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DAHLBACK, B. Procoagulant and anticoagulant properties of coagulation factor V : factor V Leiden (APC resistance) causes hypercoagulability by dual mechanisms. J Lab Clin Med. 1999, 133, 415-422
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BERNARDI, F. A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood. 1997, 90, 1552-1557
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DE VISSER, MCH. The HR2 haplotype of factor V : effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis. Thromb Haemost. 2000, 83, 577-582
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BRUGGE, J. Functional characterization of recombinant factor V molecules mimicking the R2-haplotype. XIXth congress of the International Society on Thrombosis and Haemostasis, Birmingham, England
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DAHLBACK, B. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C : prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA. 1993, 90, 1004-1008
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