Art

J-GLOBAL ID：201002273740837213   Reference number：10A0004436

The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

E3リガーゼTTC3はリン酸化Aktのユビキチン化と分解を促進する

Author (14)： SUIZU Futoshi (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  HIRAMUKI Yosuke (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  OKUMURA Fumihiko (Dep. of Biochemistry, Hokkaido Univ. Graduate School of Medicine, Sapporo, 060-8638 Japan) ,  MATSUDA Mami (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  OKUMURA Akiko J. (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  HIRATA Noriyuki (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  NARITA Masumi (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan) ,  KOHNO Takashi (Biology Div., National Cancer Center Res. Inst., Tokyo, 104-0045 Japan) ,  YOKOTA Jun (Biology Div., National Cancer Center Res. Inst., Tokyo, 104-0045 Japan) ,  BOHGAKI Miyuki (Dep. of Biochemistry, Hokkaido Univ. Graduate School of Medicine, Sapporo, 060-8638 Japan) ,  OBUSE Chikashi (Fac. of Advanced Life Sci., Hokkaido Univ., Sapporo, 060-0810 Japan) ,  HATAKEYAMA Shigetsugu (Dep. of Biochemistry, Hokkaido Univ. Graduate School of Medicine, Sapporo, 060-8638 Japan) ,  OBATA Toshiyuki (Div. of Endocrinology and Metabolism, Dep. of Medicine, Shiga Univ. of Medical Sci., Shiga, 520-2192 Japan) ,  NOGUCHI Masayuki (Div. of Cancer Biology, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo, 060-0815 Japan)
Material： Developmental Cell  (Dev Cell)
Volume： 17  Issue： 6  Page： 800-810  Publication year： Dec. 15, 2009 
JST Material Number： W1692A  ISSN： 1534-5807  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Ubiquitination ,  *serine-threonine kinase ,  post-translational modification ,  phosphorylation ,  *ubiquitin-activating enzyme ,  human ,  Amino Acid Sequence ,  active site ,  Down Syndrome ,  proteasome ,  cultured cell ,  fibroblast ,  Transfection ,  autosome ,  binding site ,  secondary structure ,  proteolysis ,  amino acid residue ,  Cell Nucleus ,  subcellular distribution ,  3T3 cell ,  Cell Cycle ,  Amino Acid Motifs ,  RING Finger Domains ,  serine residue ,  NIH 3T3 Cells ,  293T cell ,  Signal Transduction ,  Chromosomes, Human, Pair 21
Semi thesaurus term： cellular signal transduction ,  *Akt ,  *TTC3 ,  Hs52.Sk細胞 ,  Chromosomes, Human, Pair 21 ,  CMK85細胞

JST classification (4)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q) ,  Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： MG-132

Terms in the title (5)： E3リガーゼ ,  リン酸化AKT ,  ユビキチン化 ,  分解 ,  促進