Art

J-GLOBAL ID：201102214042397687   Reference number：11A1711452

Total Synthesis of Oxazolomycin A

オキサゾロマイシンAの全合成

Author (5)： ETO Kohei (Nagasaki Univ., Nagasaki, JPN) ,  YOSHINO Madoka (Nagasaki Univ., Nagasaki, JPN) ,  TAKAHASHI Keisuke (Nagasaki Univ., Nagasaki, JPN) ,  ISHIHARA Jun (Nagasaki Univ., Nagasaki, JPN) ,  HATAKEYAMA Susumi (Nagasaki Univ., Nagasaki, JPN)
Material： Organic Letters  (Org Lett)
Volume： 13  Issue： 19  Page： 5398-5401  Publication year： Oct. 07, 2011 
JST Material Number： W1171A  ISSN： 1523-7060  CODEN： ORLEF7  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic antibiotics ,  secondary metabolite ,  total synthesis ,  asymmetric synthesis ,  *cyclization reaction ,  catalytic reaction ,  metal catalyst ,  indium compound ,  *condensation reaction ,  asymmetric catalyst ,  quinoline alkaloid ,  *antibiotics ,  aliphatic amine ,  allyl compound ,  primary amine ,  organic catalysis ,  Streptomyces ,  *antibacterial drug ,  *antimicrobial drug ,  *drug ,  microorganism ,  Actinomycetales
Semi thesaurus term： Streptomyces ,  オキサゾロマイシンA

JST classification (2)： Synthesis of antibiotics  (GX04000Z) ,  Microorganism biochemistry  (EG03020N)

Substance index (14)： Allylamine ,  Oxazolomycin ,  L-3-Hydroxyisobutyric aicd ,  (2R,6R)-N,2,6-Trimethyl-N-[bis(methoxycarbonyl)methyl]-7-(benzyloxy)-3-heptyneamide ,  (4R)-1,4β-Dimethyl-3-[(R)-3-methyl-4-(benzyloxy)butylidene]-5-oxopyrrolidine-2,2-dicarboxylic acid dimethyl ester ,  (3R)-3α-Methyl-3aα-hydroxy-4α-[(R)-2-methyl-3-(benzyloxy)propyl]-6aα-(hydroxymethyl)hexahydro-1H-furo[3,4-b]pyrrole-2,6-dione ,  (2S)-1-Methyl-2,3-[methyleneoxy(diisopropylsilanediyl)oxy]-3α-[(1S,3R)-1-methoxy-3-methyl-4-oxobutyl]-4β-methyl-5-oxopyrrolidine-2α-carboxylic acid triisopropylsiloxymethyl ester ,  2-Methyl-5-(trimethylsilyl)-2-pentene-4-ynal ,  (9S)-6′-Methoxy-9-(trimethylsiloxy)cinchonan ,  (3S)-3β-Methyl-4β-[1-methyl-4-(trimethylsilyl)-1-butene-3-ynyl]oxetane-2-one ,  (3R)-2,2,4-Trimethyl-3-acetoxy-10-(5-oxazolyl)-4,6,8-decatrienoic acid ,  (2S)-1-Methyl-2,3-[methyleneoxy(diisopropylsilanediyl)oxy]-3α-[(1S,3R,4R)-1-methoxy-3-methyl-4-hydroxy-9-(9H-fluorene-9-ylmethoxycarbonylamino)-5,7-nonadienyl]-4β-methyl-5-oxopyrrolidine-2α-carboxylic acid triisopropylsiloxymethyl ester ,  (2S)-1-Methyl-2,3-[methyleneoxy(diisopropylsilanediyl)oxy]-3α-[(1S,3R,4R)-1-methoxy-3-methyl-4-acetoxy-9-[[(3R)-1-oxo-2,2,4-trimethyl-3-acetoxy-10-(5-oxazolyl)-4,6,8-decatriene-1-yl]amino]-5,7-nonadienyl]-4β-methyl-5-oxopyrrolidine-2α-carboxylic acid triisopropylsiloxymethyl ester ,  (2S)-1-Methyl-2-(hydroxymethyl)-3-hydroxy-3α-[(1S,3R,4R)-1-methoxy-3-methyl-4-hydroxy-9-[[(3R)-1-oxo-2,2,4-trimethyl-3-hydroxy-10-(5-oxazolyl)-4,6,8-decatriene-1-yl]amino]-5,7-nonadienyl]-4β-methyl-5-oxopyrrolidine-2α-carboxylic acid

Terms in the title (2)： オキサゾロマイシン ,  全合成