Research theme for competitive and other funds (8)：
2021 - 2024 オリゴデンドロサイトの力覚機構の解析と白質障害治療研究への応用
2018 - 2022 Analysis of the recovery mechanism of cell therapy to perinatal white matter injury
2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
2013 - 2018 Studies on communication between neuroaxons via oligodendrocytes.
2016 - 2018 メカニカルストレスの生理的機能の解析
2012 - 2014 Molecular mechanisms that function in oligodendrocyte myelination
2006 - 2007 神経幹細胞の増殖と分化のスイッチングを制御する機構の解析
2005 - 2006 A Molecular Mechanism Coordinating Proliferation and Differentiation of Neural Precursor Cells
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Papers (33)：
Hanako Hagio, Shiori Hosaka, Wataru Koyama, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Shoko Hososhima, Satoshi P Tsunoda, Hideaki Kandori, et al. Optogenetic manipulation of second messengers in neurons and cardiomyocytes with microbial rhodopsins and adenylyl cyclase. 2022
Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Tomohiro Sugihara, Takashi Shimizu, Mitsumasa Koyanagi, Akihisa Terakita, et al. Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells. 2022
Li J, Durose WW, Ito J, Kakita A, Iguchi Y, Katsuno M, Kunisawa K, Shimizu T, Ikenaka K. Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. Journal of Neurochemistry. 2021. 157. 2070-2090
Takeshi Shimizu, Hideji Murakoshi, Hidetoshi Matsumoto, Kota Ichino, Atsunori Hattori, Shinya Ueno, Akimasa Ishida, Naoki Tajiri, Hideki Hida. Tension sensor based on fluorescence resonance energy transfer reveals fiber diameter-dependent mechanical factors during myelination. Frontiers in Cellular Neuroscience. 2021. 15. 685044
YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation. 2017. 89. 4. 559-563
K. Kunisawa, T. Shimizu, Y. Osanai, K. Kobayashi, A. Hayashi, H. Baba, M. A. Bhat, K. Ikenaka. Analysis of neuronal responses against disruption of neuro-glial interaction and its effect on brain functions. JOURNAL OF NEUROCHEMISTRY. 2015. 134. 286-286
Roles of GSK3beta signaling in the self-renewal of neural progenitor cells. 2014. 86. 1. 68-71
備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也. 神経幹/前駆細胞における細胞周期調節因子cyclin D1は細胞周期非依存的にアストロサイト分化を阻害する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle progression). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 3P-0876
Norihisa Bizen, Takeshi Shimizu, Toshihiro Inoue, Tetsushi Kagawa, Tetsuya Taga. Cross-talk between growth and differentiation pathways in cell fate determination in the developing brain. DIFFERENTIATION. 2010. 80. S8-S8
Investigation of a novel mechanism underlying neuronal subtype-dependent myelination
(2021)
Mechanical control of oligodendrocyte morphogenesis and maturation by mechanosensors
(2018)
Roles of oligodendrocyte-neuron interactions in myelination
(2017)
Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders
(APSN, 14th Meeting of the Asian-Pacific Society for Neurochemistry 2016)
Education (3)：
2000 - 2003 The Graduate University for Advanced Studies School of Life Science Department of Physiological Sciences
1998 - 2000 Osaka University
1994 - 1998 Osaka University School of Engineering Science Direct Affiliates
Professional career (1)：
博士 (理学)
Work history (6)：
2023/04 - 現在 Shokei University
2017/08 - 2023/03 Nagoya City University
2012/04 - 2017/07 生理学研究所 助教
2010/04 - 2012/03 National University of Singapore Mechanobiology Institute postdoctoral fellow
